Results 11 to 20 of about 34,140 (239)

Vitamin B12 Prevents Cimetidine-Induced Androgenic Failure and Damage to Sperm Quality in Rats [PDF]

Frontiers in Endocrinology, 2019
Cimetidine, used as an anti-ulcer and adjuvant treatment in cancer therapy, causes disorders in the male reproductive tract, including steroidogenesis. However, its effect on sperm quality and male fertility has been poorly addressed.
Flávia Luciana Beltrame, Fabiane de Santi, Vanessa Vendramini, Regina Elizabeth Lourenço Cabral, Sandra Maria Miraglia, Paulo Sérgio Cerri, Estela Sasso-Cerri   +6 more
doaj   +2 more sources

Cimetidine Attenuates Therapeutic Effect of Anti-PD-1 and Anti-PD-L1 and Modulates Tumor Microenvironment in Colon Cancer [PDF]

Biomedicines
Histamine modulates immunity by binding to histamine receptor 2 (H2R). Cimetidine, an H2R antagonist that inhibits gastric acid secretion and treats gastrointestinal ulcers, interferes with histamine-mediated immunomodulation and may have anticancer ...
Feng-Chi Kuo, Jerry Cheng-Yen Lai, Hui-Ru Shieh, Wan-Zu Liou, Ming-Jong Bair, Yu-Jen Chen   +5 more
doaj   +2 more sources

Ameliorative effects of Brassica oleracea var. viridis ethanol extract and fractions on cimetidine-induced reproductive toxicity in male Wistar rats [PDF]

Frontiers in Veterinary Science
BackgroundMale infertility is a global health issue, with pharmaceutical agents such as cimetidine contributing significantly to gonadotoxicity through antiandrogenic and oxidative mechanisms.
Emmanuel Orire Ikuomola, Daniel Udofia Owu, Victor Otu Oka, Olufunke Onaadepo, Felix Nnaemeka Ugwu, Patrick Maduabuchi Aja   +5 more
doaj   +2 more sources

Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice. [PDF]

CNS Neurosci Ther
Pitolisant, an FDA‐approved H3R antagonist, counteracts the rewarding and sedative effects of ethanol, reduces alcohol intake, and alleviates the negative affect during withdrawal. This might occur via the antagonism of presynaptic autoreceptors and heteroreceptors H3Rs in the lateral habenula, thereby activating the H2R/p‐CREB/BDNF signaling and ...
Zhao Y, Fu Y, Liu T, Yang Z, Yang Z, Chen B, Zhou L, Yang J, Chen D, Han X, Tang Y, Ye JH, Miao CY, Fu R.   +13 more
europepmc   +2 more sources

COMPARSION OF PREVENTIVE EFFECT OF CIMETIDINE AND QUINACRINE ON STRESS AND ASPIRIN INDUCED PEPTIC ULCER

Journal of Research in Medical Sciences, 2002
Introduction. Cimetidine and quinacrine have protective effect on gastroduodenal lesions. In this study we compared efficacy of cimetidine and quinacrine for prevention of stress and aspirin Induced Peptic Ulcer. Methods.
L BORJIAN, A.R RAHMANI
doaj   +1 more source

Case Report: Oral Cimetidine Administration Causes Drug-Induced Immune Hemolytic Anemia by Eliciting the Production of Cimetidine-Dependent Antibodies and Drug-Independent Non-specific Antibodies

Frontiers in Medicine, 2021
Previously, it was reported that multiple patients had hemolytic anemia associated with cimetidine administration, while only one patient who had received intravenous cimetidine was serologically diagnosed with drug-induced immune hemolytic anemia (DIIHA)
Yuanjun Wu, Yong Wu, Yanli Ji, Yanhui Liu, Dongsheng Wu, Jiajie Liang, Ganping Guo, Baochan Chen   +7 more
doaj   +1 more source

Cimetidine hepatitis

Gastroenterology, 1979
This case of an adult with cimetidine-induced hepatitis is presented. An etiologic role for the drug was strongly suggested when the patient developed transient hepatic dysfunction after two reexposures to cimetidine, which reverted promptly on withdrawal of the drug.
J P, Villeneuve, H A, Warner
openaire   +4 more sources

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale. [PDF]

Geriatr Gerontol Int
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Mogi M, Liu S, Suzuki Y, Shibata Y, Yamada S.   +4 more
europepmc   +2 more sources

Pengaruh Jus Buah Pepaya (Carica papaya L.) terhadap Profil Farmakokinetik Simetidin pada Tikus Putih (Rattus norvegicus)

Journal of Tropical Pharmacy and Chemistry, 2016
Drugs used with foods or drinks can affect the drug effects. This study aims to observe the effect of papaya juice (Carica papaya L.) to the pharmacokinetics profile of cimetidine in white rats. The animal were randomly in three group.
Siti Julaicha, Adam M. Ramadhan, Rolan Rusli   +2 more
doaj   +1 more source

Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode, Protospirura muricola, in vitro and in vivo [PDF]

, 2007
Cysteine proteinases from the fruit and latex of plants, including papaya, pineapple and fig, were previously shown to have a rapid detrimental effect, in vitro, against the rodent gastrointestinal nematodes, H eligmosomoides polygyrus (which is found in
Behnke, J.M., Buttle, D.J., Duce, I.R., Lowe, A.E., Stepek, G.   +4 more
core   +3 more sources