Results 41 to 50 of about 24,926 (162)
British Journal of Clinical Pharmacology, Volume 91, Issue 6, Page 1739-1748, June 2025.Abstract Aims Since omeprazole and esomeprazole reduce the effect of clopidogrel on the inhibition of platelet aggregation, concomitant use of these drugs has been discouraged by the Food and Drug Administration (FDA) and European Medicines Agency (EMA) since 2010.
Sarah Wilkes +5 more
wiley +1 more source
Humphrey Center News: Spring/Summer 1986 v. 2, no. 2 [PDF]
, 1986 Newsletter of the Hubert H.
Beldekas, John C. +3 more
core
Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo [PDF]
, 2014 BACKGROUND: Drug transporters play important roles in the absorption, distribution, and elimination of drugs and thereby, modulate drug efficacy and toxicity. With a growing use of poly pharmacy, concurrent administration of herbal extracts that modulate
Eun Nam Kim +8 more
core +1 more source
Health Science Reports, Volume 8, Issue 5, May 2025.ABSTRACT Background and Aims Chronic Spontaneous Urticaria is characterized by the sudden onset of itchy wheals and angioedema and is primarily driven by mast cells. It can have a significant impact on the Quality of Life (QoL) of an individual. While the role of mast cells in urticaria is extensively described, the link between sleep disorders and ...
Asad Ullah Wasim +8 more
wiley +1 more source
Health Science Reports, Volume 8, Issue 5, May 2025.ABSTRACT Background and Aims Intralesional immunotherapy is an upcoming method of wart treatment with fewer side effects and this study aims to assess and compare the efficacy of intralesional MMR vaccine and vitamin D3 in the treatment of nongenital warts.
Bibisha Baaniya +3 more
wiley +1 more source
Pharmacoepidemiology and Drug Safety, Volume 34, Issue 5, May 2025.ABSTRACT Purpose Tamoxifen is guideline treatment for premenopausal women with estrogen receptor‐positive (ER+) breast cancer. Therapeutic efficacy relies partly on tamoxifen biotransformation by CYP2D6, CYP2C19, and CYP3A4 enzymes. We conducted a cohort study to evaluate whether concomitant prescription of drugs that inhibit these enzymes impacted ...
Kirsten M. Woolpert +11 more
wiley +1 more source
Relevance of copper and organic cation transporters in the activity and transport mechanisms of an anticancer cyclometallated gold(III) compound in comparison to cisplatin [PDF]
, 2018 The molecular mechanisms of toxicity and cellular transport of anticancer metallodrugs, including platinum-based agents, have not yet been fully elucidated.
Bertrand, Benoît +5 more
core +6 more sources
Potential mechanisms underlying pathological fatigue‐induced cardiac dysfunction
The FASEB Journal, Volume 39, Issue 8, 30 April 2025.The present study developed a novel animal model of pathological fatigue‐induced cardiac dysfunction through a 5‐week combined stress protocol, which included loaded swimming, sleep deprivation, and restraint stress. Five‐week combined stress induced fatigue‐like phenotypes, impaired left ventricular systolic function, and upregulation of a series of ...
Hanying Li +8 more
wiley +1 more source
Cimetidine, C10H16N6S, formC: crystal structure and modelling of polytypes using suoperspace approach [PDF]
, 2013 An efficient method for modelling a polytypic family is presented with the example of cimetidine in the form C polymorph. The method exploits the (3 + 1)-dimensional superspace model, which is a powerful tool for the description, prediction and ...
Arakcheeva, A. +4 more
core +1 more source
Signal transduction mechanism of biased ligands at histamine H2 receptors [PDF]
, 2014 7TMRs (seven-transmembrane receptors) exist as conformational collections in which different conformations would lead to differential downstream behaviours such as receptor phosphorylation, G-protein activation and receptor internalization.
Alonso, Natalia +5 more
core +1 more source