Results 11 to 20 of about 187,468 (290)

Cinchona Alkaloids in Asymmetric Organocatalysis [PDF]

Synthesis, 2010
This article reviews the applications of cinchona alkaloids as asymmetric catalysts. In the last few years, characterized by the resurgence of interest in asymmetric organocatalysis, cinchona derivatives have been shown to catalyze an outstanding array of chemical reactions, often with remarkable stereoselectivity. This work presents an overview of the
Marcelli, T., Hiemstra, H.
openaire   +4 more sources

Role of Cinchona Alkaloids in the Enantio- and Diastereoselective Synthesis of Axially Chiral Compounds. [PDF]

Acc Chem Res, 2022
Portolani C, Centonze G, Righi P, Bencivenni G.   +3 more
europepmc   +3 more sources

Hybrids of Cinchona Alkaloids and Bile Acids as Antiparasitic Agents Against Trypanosoma cruzi [PDF]

Molecules, 2019
The current chemotherapy of Chagas disease needs to be urgently improved. With this aim, a series of 16 hybrids of Cinchona alkaloids and bile acids were prepared by functionalization at position C-2 of the quinoline nucleus by a radical attack of a ...
Daniel Musikant, Aurélie Leverrier, Diana Bernal, Gabriel Ferri, Jorge A. Palermo, Martin M. Edreira   +5 more
doaj   +2 more sources

Synthesis, Antibacterial Properties and Molecular Docking Studies of Nitrogen Substituted 9-(((4X-But-2-ynyloxy)methyl)-1,2,3-triazolyl)–Cinchona Alkaloid Conjugates [PDF]

Molecules
The year 2024 marked the 80th anniversary of Woodward’s total synthesis of quinine. Quinine is a natural alkaloid from the bark of the cinchona tree that has been used for years as an antimalarial drug.
Gulim K. Mukusheva, Nurizat N. Toigambekova, Victor A. Savelyev, Andrey I. Khlebnikov, Liubov G. Burova, Sofiia D. Afanaseva, Oralgazy A. Nurkenov, Anarkul S. Kishkentayeva, Aikerim S. Olzhabayeva, Yurii V. Gatilov, Roza B. Seidakhmetova, Alexander N. Evstropov, Elvira E. Shults   +12 more
doaj   +2 more sources

5613398 A DRUG REPOSITIONING PROJECT FOR Β-THALASSEMIA: SIROLIMUS AND CINCHONA ALKALOIDS [PDF]

HemaSphere, 2023
M.L.P. Michele Lipucci Di Paola, C.Z. Cristina Zuccato, L.C.C. Lucia Carmela Cosenza, M.Z. Matteo Zurlo, M.B. Monica Borgatti, I.L. Ilaria Lampronti, C.T.S. Chris Sotirelis, M.P. Marco Prosdocimi, R.G. Roberto Gambari, A.F. Alessia Finotti   +9 more
doaj   +2 more sources

A near-complete genome assembly of Cinchona calisaya [PDF]

Scientific Data
Rubiaceae plants are globally widespread and possess significant economic and medicinal value. Such as the globally important crop of coffee, and Cinchona calisaya Wedd., which is rich in alkaloids, is an important medicinal resource for treating malaria.
Cailian Du, Yao Xiao, Jin Liu, Qiang He, Wei Li, Wenzhao Xie   +5 more
doaj   +2 more sources

<i>Cinchona</i> alkaloid copolymers as fluorimetric INHIBIT and colorimetric AND logic gates for detection of iodide. [PDF]

RSC Adv
Agius N, Ashton CJ, Willcock H, Magri DC.   +3 more
europepmc   +3 more sources

Cinchona officinalis Phytochemicals-Loaded Iron Oxide Nanoparticles Induce Cytotoxicity and Stimulate Apoptosis in MCF-7 Human Breast Cancer Cells

Nanomaterials, 2022
The present study aimed to synthesize iron oxide nanoparticles loaded with quinine and alkaloids-rich Cinchona officinalis (Peruvian bark) stem bark extract, and further evaluate their cytotoxic effect and apoptosis mechanisms in MCF-7 breast cancer ...
Laila Naif Al-Harbi, Ghedier M. Al-Shammari, Pandurangan Subash-Babu, Mohammed A. Mohammed, Roaa Ahmed Alkreadees, Abu ElGasim Ahmed Yagoub   +5 more
doaj   +1 more source

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]

, 2002
Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Docampo, Flohe, Moreno, Viode, Henderson, Walsh, Krauth-Seigel, Muller, Nogoceke, Tetaud, Wilkinson, Wilkinson, Tetaud, Wilkinson, Boveris, Fairlamb, Mehlotra, Carnieri, Kendall, Kelly, Gibson, Martinez-Calvillo, Kelly, Kelly, Kelly, Cannata, Rutter, Easterby, Gommel, Steinert, Sommer, Opperdoes, Opperdoes, Michels, Parsons, Blattner, Bjornstedt, Sztajer, Horiguchi, Holgren, Fabianek, Shih, Shih, van den Bosch, Subramani, Keller, Singh, Singh, Boveris, Duffieux, Goodman, Knoops, Yamashita, Verdoucq, Seo, Lopez, Krieger   +56 more
core   +4 more sources

Enantioselective Desymmetrization by Chiral Bifunctional H-Bonding Organocatalysts. [PDF]

Chemistry
Enantioselective desymmetrization has emerged as a highly efficient and conceptually elegant strategy for the construction of chiral molecules from readily available prochiral substrates. This review focuses on recent developments in organocatalytic desymmetrization reactions, with particular emphasis on approaches involving bifunctional activation ...
Urban M, Veselý J.
europepmc   +2 more sources