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Cinchona ledgeriana produces several secondary metabolites. The main quinoline alkaloid, quinine that is widely used as an antimalarial drug, is most commonly extracted from the bark of Cinchona, and its leaves contain several other metabolites.
Dian Rahma Pratiwi +2 more
doaj +1 more source
A simple and rapid access to fluorinated dithioesters was developed by a one-pot sequence corresponding to a Grignard reaction—Mitsunobu type substitution. These activated dithioesters have shown excellent reactivity in an aminolysis reaction from simple
Aimar Gonzalo-Barquero +3 more
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Recent Progress in Applications of Cinchona Alkaloids and Their Derivatives in Asymmetric Catalysis
Cinchona alkaloids widely exist in nature, which have attracted extensive interest of researchers because of their readily availability, biological activity, unique structural properties, and easy modification.
Shuang Xu +3 more
semanticscholar +1 more source
Quinoline Alkaloids in Suspension Cultures of Cinchona ledgeriana Treated with Various Substances
Cinchona alkaloids are in extensive uses, not only for drugs but also for soft drink industries. They are harvested from the bark of trees Cinchona spp. after certain ages and therefore are available over a limited time.
DIAH RATNADEWI, SUMARYONO
doaj +3 more sources
The Fever Tree: from Malaria to Neurological Diseases
This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine.
Sara Eyal
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How cinchona alkaloid-derived primary amines control asymmetric electrophilic fluorination of cyclic ketones. [PDF]
The origin of selectivity in the α-fluorination of cyclic ketones catalyzed by cinchona alkaloid-derived primary amines is determined with density functional calculations.
Houk, KN, Lam, Yu-hong
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Enantioselective Organocatalytic Diels-Alder Trapping of Photochemically Generated Hydroxy-o-Quinodimethanes [PDF]
The photoenolization/Diels-Alder strategy offers straightforward access to synthetically valuable benzannulated carbocyclic products. This historical light-triggered process has never before succumbed to efforts to develop an enantioselective catalytic ...
Cuadros, Sara +3 more
core +2 more sources
Amide-Based Cinchona Alkaloids as Phase-Transfer Catalysts: Synthesis and Potential Application.
Herein we present a library of simple amide derivatives of Cinchona alkaloids in the form of quaternary ammonium salts. The obtained derivatives can be generated very easily and efficiently from inexpensive and commercially available substrates.
Maciej Majdecki +2 more
semanticscholar +1 more source
A fluorous cinchona alkaloid ester has been developed as a chiral promoter for the asymmetric fluorination of β-ketoesters. It has comparable reactivity and selectivity to the nonfluorous versions of cinchona alkaloids and can be easily recovered from ...
Wen-Bin Yi +5 more
doaj +1 more source

