Results 51 to 60 of about 187,468 (290)

Synthesis, Biological Evaluation and Machine Learning Prediction Model for Fluorinated Cinchona Alkaloid-Based Derivatives as Cholinesterase Inhibitors

Pharmaceuticals, 2022
A series of 46 Cinchona alkaloid derivatives that differ in positions of fluorine atom(s) in the molecule were synthesized and tested as human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors.
Alma Ramić, Ana Matošević, Barbara Debanić, Ana Mikelić, Ines Primožič, Anita Bosak, Tomica Hrenar   +6 more
doaj   +1 more source

N-(2-Bromobenzyl)cinchoninium bromide

Acta Crystallographica Section E, 2012
The title compound {systematic name: 1-(2-bromobenzyl)-5-ethenyl-2-[hydroxy(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide}, C26H28BrN2O+·Br−, is a chiral quaternary ammonium salt of one of the Cinchona alkaloids.
Agnieszka Skórska-Stania, Magdalena Jezierska-Zięba, Barbara Kąkol, Michał Fedoryński, Barbara J. Oleksyn   +4 more
doaj   +1 more source

A green access to supported cinchona alkaloid amide catalysts for heterogeneous enantioselective allylsilylation of aldehydes and process intensity evaluation in batch and flow

Green Synthesis and Catalysis, 2022
We report herein a new class of polystyrene-supported cinchona alkaloid amide catalysts for enantioselective allylation of various aldehydes using allyltrichlorosilane under both batch and continuous flow conditions.
Xiao Qian Ng, Ming Han Kang, Ren Wei Toh, Valerio Isoni, Jie Wu, Yu Zhao   +5 more
doaj   +1 more source

Phylogeny Predicts the Quantity of Antimalarial Alkaloids within the Iconic Yellow Cinchona Bark (Rubiaceae: Cinchona calisaya)

Frontiers in Plant Science, 2017
Considerable inter- and intraspecific variation with respect to the quantity and composition of plant natural products exists. The processes that drive this variation remain largely unknown.
Carla Maldonado, C. Barnes, C. Cornett, Else Holmfred, S. Hansen, C. Persson, A. Antonelli, N. Rønsted   +7 more
semanticscholar   +1 more source

Isoindolinones as Michael Donors under Phase Transfer Catalysis: Enantioselective Synthesis of Phthalimidines Containing a Tetrasubstituted Carbon Stereocenter

Molecules, 2015
Readily available chiral ammonium salts derived from cinchona alkaloids have proven to be effective phase transfer catalysts in the asymmetric Michael reaction of 3-substituted isoindolinones.
Francesco Scorzelli, Antonia Di Mola, Laura Palombi, Antonio Massa   +3 more
doaj   +1 more source

Cinchona-Derived Picolinamides: Effective Organocatalysts for Stereoselective Imine Hydrosilylation [PDF]

, 2014
Picolinamide-cinchona organocatalysts for the successful enantioselective reduction of ketomines were developed. For the first time, a new type of chiral Lewis base, a cationic species, is reported to efficiently organocatalyze the addition of ...
Andrea, Genoni, Barrulas, Pedro, Benaglia, Maurizio, Burke, Anthony   +3 more
core   +1 more source

Quantitative determination of major alkaloids in Cinchona bark by Supercritical Fluid Chromatography

Journal of Chromatography A, 2018
Chinoline alkaloids found in Cinchona bark still play an important role in medicine, for example as anti-malarial and antiarrhythmic drugs. For the first time Supercritical Fluid Chromatography has been utilized for their separation.
Adele Murauer, M. Ganzera
semanticscholar   +1 more source

Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance

Chemistry – A European Journal, EarlyView.
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini, Daniele Lavelli, Alberto Dal Corso, Luca Pignataro   +3 more
wiley   +1 more source

Poly(L-lactide) Epimerization and Chain Scission in the Presence of Organic Bases

Macromol, 2022
Organocatalysis for polymer chemistry has become a subject of significant interest in the last two decades. In this contribution, we have studied the evolution of the microstructure of poly(L-lactide) in solution in toluene at 105 °C in the presence of ...
Julie Meimoun, Audrey Favrelle-Huret, Julien De Winter, Philippe Zinck   +3 more
doaj   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source