Results 31 to 40 of about 469 (131)

A case report of ciprofol overdose during anesthesia/analgesia and literature review: clinical presentation, blood pressure, and management

Journal of International Medical Research, 2022
Ciprofol is a novel intravenous anesthetic agent and a highly selective gamma-aminobutyric acid-A receptor agonist, similar to propofol. This is the first report about ciprofol overdose occurring during the maintenance phase of anesthesia for a surgical ...
Ai Wei, Lina Yang, Shijin Ma, Gang Jin, Mengchang Yang, Jiaojie Zhou   +5 more
doaj   +1 more source

Anesthesia with ciprofol in cardiac surgery with cardiopulmonary bypass: A case report

World Journal of Clinical Cases, 2023
Ciprofol is a novel agent for intravenous general anesthesia. In February 2022, it was approved by the National Medical Products Administration for general anesthesia induction and maintenance. It has the advantages of fast onset, fast elimination, stable circulation, and few adverse reactions.
Yu, Le, Bischof, Evelyne, Lu, Hui-Hong
openaire   +2 more sources

Efficacy and safety of ciprofol-remifentanil versus propofol-remifentanil during fiberoptic bronchoscopy: A prospective, randomized, double-blind, non-inferiority trial

Frontiers in Pharmacology, 2022
Objective: Ciprofol is a novel 2,6-disubstituted phenol derivative that has improved pharmacokinetic and pharmacodynamic properties compared with propofol.
Bin Wu, Wenchao Zhu, Qinghe Wang, Chunguang Ren, Lizhen Wang, Guannan Xie   +5 more
doaj   +1 more source

Safety and efficacy of ciprofol vs. propofol for sedation in intensive care unit patients with mechanical ventilation: a multi-center, open label, randomized, phase 2 trial

Chinese Medical Journal, 2022
. Background:. Ciprofol (HSK3486; Haisco Pharmaceutical Group Co., Ltd., Chengdu, China), developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous ...
Yongjun Liu, Xiangyou Yu, Duming Zhu, Jun Zeng, Qinhan Lin, Bin Zang, Chuanxi Chen, Ning Liu, Xiao Liu, Wei Gao, Xiangdong Guan, Jing Ni   +11 more
doaj   +1 more source

The Effect of Different Doses of Ciprofol in Patients with Painless Gastrointestinal Endoscopy

Drug Design, Development and Therapy, 2023
Ciprofol is currently used for painless gastrointestinal endoscopy and anesthesia induction. However, whether it is superior to propofol and its optimal dose remains unknown.A total of 149 patients, 63 males and 86 females, aged 18-80 years, BMI 18-28 kg/m2, ASA I-III, were divided randomly into four groups: propofol group (group P, n = 44), ciprofol 0.
Lini Chen, Yongguo Xie, Xueke Du, Weiyong Qin, Lifu Huang, Junmin Dai, Ke Qin, Jianfeng Huang   +7 more
openaire   +4 more sources

Issue Information

, 2023
Clinical and Translational Science, Volume 16, Issue 10, Page 1737-1740, October 2023.
wiley   +1 more source

Pharmacokinetics, pharmacodynamics, and safety of ciprofol emulsion in Chinese subjects with normal or impaired renal function

Frontiers in Pharmacology, 2023
Background: Ciprofol, a novel sedative–hypnotic drug, has been approved for its use in inducing and maintaining general anesthesia, as well as for providing sedation.Methods: In this phase I, single-center, parallel, controlled, open-label clinical trial,
Jun Tao, Jun Tao, Shuaibing Liu, Shuaibing Liu, Ying Ying Zhao, Lei Qi, Pangke Yan, Nan Wu, Xiao Liu, Dongwei Liu, Xin Tian, Xin Tian   +11 more
doaj   +1 more source

Pharmacological mechanism and clinical application of ciprofol

Frontiers in Pharmacology
Propofol has become one of the most commonly used anesthetic agents because of its good sedative effects, rapid onset, and fast metabolism. However, its associated respiratory and circulatory depression and injection pain make it difficult for patients to tolerate.
Jianshun Zhou, Lifeng Wang, Lifeng Wang, Zhaoying Zhong, Lei Yuan, Jinhua Huang, Ping Zou, Xiaohui Cao, Donglan Peng, Baozhen Liao, Jianqiang Zeng   +10 more
openaire   +3 more sources

Recovery Profiles and Well‐Being Outcomes in Patients Undergoing Various Anaesthesia Techniques: A Systematic Review

Health Science Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Background and Aim An appropriate anaesthesia technique is considered for the patient's health status to ensure a painless recovery. This study explored the important role of anesthesia selection in improving recovery outcomes and patient well‐being across diverse surgical settings.
Abdullah K. Bubshait
wiley   +1 more source

ED50 of ciprofol combined with different doses of remifentanil during upper gastrointestinal endoscopy in school-aged children: a prospective dose-finding study using an up-and-down sequential allocation method

Frontiers in Pharmacology
ObjectiveThis study aimed to determine the 50% effective dose (ED50) of ciprofol when combined with different doses of remifentanil for upper gastrointestinal endoscopy of school-age children and to evaluate its safety.MethodsThis study involved school ...
Xu Zhang, Xu Zhang, Ning Zhang, Haicheng Song, Yueyi Ren   +4 more
doaj   +1 more source