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Circadian clock: a regulator of the immunity in cancer
Cell Communication and Signaling, 2021 The circadian clock is an endogenous timekeeper system that controls and optimizes biological processes, which are consistent with a master circadian clock and peripheral clocks and are controlled by various genes.
Zhen Zhang +5 more
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Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion
Frontiers in Immunology, 2019 Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved.
Yingcheng Wu +6 more
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Evidence for widespread dysregulation of circadian clock progression in human cancer [PDF]
PeerJ, 2018 The ubiquitous daily rhythms in mammalian physiology are guided by progression of the circadian clock. In mice, systemic disruption of the clock can promote tumor growth. In vitro, multiple oncogenes can disrupt the clock.
Jarrod Shilts +2 more
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Barley Hv CIRCADIAN CLOCK ASSOCIATED 1 and Hv PHOTOPERIOD H1 Are Circadian Regulators That Can Affect Circadian Rhythms in Arabidopsis. [PDF]
PLoS ONE, 2015 Circadian clocks regulate many aspects of plant physiology and development that contribute to essential agronomic traits. Circadian clocks contain transcriptional feedback loops that are thought to generate circadian timing.
Jelena Kusakina +7 more
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Mood phenotypes in rodent models with circadian disturbances
Neurobiology of Sleep and Circadian Rhythms, 2022 Many physiological functions with approximately 24-h rhythmicity (circadian rhythms) are generated by an internal time-measuring system of the circadian clock.
Kiyomichi Imamura, Toru Takumi
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NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators. [PDF]
PLoS Genetics, 2016 Heterodimers of CLOCK and BMAL1 are the major transcriptional activators of the mammalian circadian clock. Because the paralog NPAS2 can substitute for CLOCK in the suprachiasmatic nucleus (SCN), the master circadian pacemaker, CLOCK-deficient mice ...
Dominic Landgraf +3 more
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The Plant Cell, 2020 The rice circadian clock integrates sugar signaling and regulates expression of strigolactone pathway genes to control tillering and panicle development.
F. Wang +7 more
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Circadian clock—A promising scientific target in oral science
Frontiers in Physiology, 2022 The oral and maxillofacial organs play vital roles in chewing, maintaining facial beauty, and speaking. Almost all physiological processes display circadian rhythms that are driven by the circadian clock, allowing organisms to adapt to the changing ...
Guangxia Feng +16 more
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The Circadian Clock and Viral Infections
Journal of Biological Rhythms, 2020 The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks ...
Helene Borrmann, J. McKeating, X. Zhuang
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Silybin A enhances circadian clock by targeting CRY1 and disrupting its interaction with CLOCK
Pharmacological Research - Modern Chinese Medicine, 2022 Circadian clock governs a large array of physiological and metabolic functions. The amplitude decline of circadian rhythm is associated with various chronic diseases. However, few clock enhancing-molecules are known. CRY1 is one of the main components of
Weijie Bian +4 more
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