Results 11 to 20 of about 347,727 (386)

The Circadian Clock and Viral Infections [PDF]

Journal of Biological Rhythms, 2020
The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks in peripheral tissues, thereby regulating our immune system and the severity of infections.
Helene Borrmann, Jane A McKeating, Xiaodong Zhuang   +2 more
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Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion

Frontiers in Immunology, 2019
Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved.
Yingcheng Wu, Baorui Tao, Baorui Tao, Tianyang Zhang, Yihui Fan, Yihui Fan, Renfang Mao   +6 more
doaj   +2 more sources

Cancer and the Circadian Clock

Cancer Research, 2019
Abstract The circadian clock is a master regulator of mammalian physiology, regulating daily oscillations of crucial biological processes and behaviors. Notably, circadian disruption has recently been identified as an independent risk factor for cancer and classified as a carcinogen.
Ayesha A. Shafi, Karen E. Knudsen
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Neurodegeneration and the Circadian Clock [PDF]

Frontiers in Aging Neuroscience, 2017
Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished hormone release) and biochemical ...
Hood, Suzanne, Amir, Shimon
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The contribution of circadian clock to the biological processes [PDF]

Frontiers in Molecular Biosciences
All organisms have various circadian, behavioral, and physiological 24-h periodic rhythms, which are controlled by the circadian clock. The circadian clock controls various behavioral and physiological rhythms.
Beibei Luo, Beibei Luo, Beibei Luo, Jiangyuan Song, Jiangyuan Song, Jiangyuan Song, Jiaqi Zhang, Jiaqi Zhang, Jiaqi Zhang, Jun Han, Jun Han, Jun Han, Xin Zhou, Xin Zhou, Xin Zhou, Lili Chen, Lili Chen, Lili Chen   +17 more
doaj   +2 more sources

Evidence for widespread dysregulation of circadian clock progression in human cancer [PDF]

PeerJ, 2018
The ubiquitous daily rhythms in mammalian physiology are guided by progression of the circadian clock. In mice, systemic disruption of the clock can promote tumor growth. In vitro, multiple oncogenes can disrupt the clock.
Jarrod Shilts, Guanhua Chen, Jacob J. Hughey   +2 more
doaj   +3 more sources

When lowering temperature, the in vivo circadian clock in cyanobacteria follows and surpasses the in vitro protein clock trough the Hopf bifurcation. [PDF]

Sci Rep
The in vivo circadian clock in single cyanobacteria is studied here by time-lapse fluorescence microscopy when the temperature is lowered below 25{\deg}C . We first disentangle the circadian clock behavior from the bacterial cold shock response by identifying a sequence of "death steps" based on cellular indicators. By analyzing only "alive" tracks, we
Mihalcescu I, Kaji H, Maruyama H, Giraud J, Van Melle-Gateau M, Houchmandzadeh B, Ito H.   +6 more
europepmc   +2 more sources

Effect of circadian clock disruption on type 2 diabetes [PDF]

Frontiers in Physiology
IntroductionType 2 diabetes (T2D) is the predominant form of diabetes mellitus and is among the leading causes of death with an increasing prevalence worldwide. However, the pathological mechanism underlying T2D remains complex and unclear. An increasing
Hong Thuan Tran, Hong Thuan Tran, Takeru Kondo, Amal Ashry, Yunyu Fu, Hiroko Okawa, Chenphop Sawangmake, Chenphop Sawangmake, Chenphop Sawangmake, Hiroshi Egusa   +9 more
doaj   +2 more sources

The Circadian Clock in Lepidoptera [PDF]

Frontiers in Physiology, 2021
With approximately 160,000 identified species of butterflies and moths, Lepidoptera are among the most species-rich and diverse insect orders. Lepidopteran insects have fundamental ecosystem functions as pollinators and valuable food sources for countless animals.
Brady D., Saviane A., Cappellozza S., Sandrelli F.   +3 more
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The photobiology of the human circadian clock [PDF]

Proceedings of the National Academy of Sciences, 2021
Significance The function of our biological clock is dependent on environmental light. Rodent studies have shown that there are multiple colors that affect the clock, but indirect measures in humans suggest blue light is key. We performed functional MRI studies in human subjects with unprecedented spatial resolution to investigate color ...
Robin A. Schoonderwoerd, Mischa de Rover, Jan A.M. Janse, Lydiane Hirschler, Channa R. Willemse, Leonie Scholten, Ilse Klop, Sander van Berloo, Matthias J.P. van Osch, Dick F. Swaab, Johanna H. Meijer   +10 more
openaire   +6 more sources