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Cancer and the Circadian Clock.
Cancer Research, 2019 The circadian clock is a master regulator of mammalian physiology, regulating daily oscillations of crucial biological processes and behaviors. Notably, circadian disruption has recently been identified as an independent risk factor for cancer and ...
Ayesha A. Shafi, K. Knudsen
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Neurodegeneration and the Circadian Clock [PDF]
Frontiers in Aging Neuroscience, 2017 Despite varied etiologies and symptoms, several neurodegenerative diseases—specifically, Alzheimer’s (AD), Parkinson’s (PD), and Huntington’s diseases (HDs)—share the common feature of abnormal circadian rhythms, such as those in behavior (e.g ...
S. Hood, S. Amir
semanticscholar +5 more sources
Circadian clocks and breast cancer [PDF]
Breast Cancer Research, 2016 Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Blakeman, V +3 more
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The Circadian Clock in Lepidoptera [PDF]
Frontiers in Physiology, 2021 With approximately 160,000 identified species of butterflies and moths, Lepidoptera are among the most species-rich and diverse insect orders. Lepidopteran insects have fundamental ecosystem functions as pollinators and valuable food sources for countless animals.
Brady D. +3 more
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The photobiology of the human circadian clock [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance The function of our biological clock is dependent on environmental light. Rodent studies have shown that there are multiple colors that affect the clock, but indirect measures in humans suggest blue light is key. We performed functional MRI studies in human subjects with unprecedented spatial resolution to investigate color ...
Robin A. Schoonderwoerd +10 more
openaire +6 more sources
Cell, 2001 The circadian clock in all organisms is so intimately linked to light reception that it appears as if evolution has simply wired a timer into the mechanism that processes photic information. Several recent studies have provided new insights into the role of light input pathways in the circadian system of Arabidopsis.
Till Roenneberg, Martha Merrow
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The circadian clock and asthma [PDF]
Thorax, 2013 It is characteristic of asthma that symptoms worsen overnight, particularly in the early hours of the morning. Nocturnal symptoms in asthma are common and are an important indicator for escalation of treatment. An extensive body of research has demonstrated that nocturnal symptoms of cough and dyspnea are accompanied by circadian variations in airway ...
Durrington, Hannah J. +3 more
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Circadian Biology: Clocks within Clocks [PDF]
Current Biology, 2005 A small cluster of approximately 20,000 neurons in the ventral hypothalamus provide the body with key time-keeping signals and drive circadian rhythms. This circadian clock exhibits surprisingly complex substructures, with inputs from the retina, and outputs to other brain structures.
Piggins, Hugh D., Loudon, Andrew
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The circadian clock of cyanobacteria [PDF]
BioEssays, 2000 A circadian clock, with physiological characteristics similar to those of eukaryotes, functions in the photosynthetic prokaryote, cyanobacteria. The molecular mechanism of this clock has been efficiently dissected using a luciferase reporter gene that reports the status of the clock.
Masahiro Ishiura, Takao Kondo
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Circadian clocks in the ovary [PDF]
Trends in Endocrinology & Metabolism, 2010 Clock gene expression has been observed in tissues of the hypothalamic-pituitary-gonadal (HPG) axis. Whereas the contribution of hypothalamic oscillators to the timing of reproductive biology is well known, the role of peripheral oscillators like those in the ovary is less clear.
Michael Menaker, Michael T. Sellix
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