Results 11 to 20 of about 47,618 (242)
Crosstalk between the circadian clock and innate immunity in Arabidopsis. [PDF]
PLoS Pathogens, 2013 The circadian clock integrates temporal information with environmental cues in regulating plant development and physiology. Recently, the circadian clock has been shown to affect plant responses to biotic cues.
Chong Zhang +10 more
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Cell, 2017 Most creatures on this planet possess an ability to anticipate upcoming events in the environment, courtesy of their circadian clocks. This allows them to prepare for those changes instead of being caught by surprise, which could mean the difference between life and death. In this SnapShot, we describe the basics of how the clock ticks.
Bryan J, Song, Dragana, Rogulja
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Neoplasia: An International Journal for Oncology Research, 2015 Clock circadian regulator (CLOCK)/brain and muscle arnt-like protein-1 (BMAL1) complex governs the regulation of circadian rhythm through triggering periodic alterations of gene expression.
Ming Cui +5 more
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Circadian Clocks and Pregnancy [PDF]
Frontiers in Endocrinology, 2014 The recognition that 24-h rhythmic processes (“circadian”) underlie many endocrine functions has added a fascinating new temporal dimension to our appreciation of their complexity. Research from various laboratories has revealed circadian gene expression in multiple tissues in the reproductive system of non-pregnant and pregnant mammals.
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Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion
Frontiers in Immunology, 2019 Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved.
Yingcheng Wu +6 more
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Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells. [PDF]
PLoS ONE, 2014 U2OS cells harbor a circadian clock but express only a few rhythmic genes in constant conditions. We identified 3040 binding sites of the circadian regulators BMAL1, CLOCK and CRY1 in the U2OS genome. Most binding sites even in promoters do not correlate
Julia Hoffmann +5 more
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PLoS Biology, 2020 A ubiquitous feature of the circadian clock across life forms is its organization as a network of cellular oscillators, with individual cellular oscillators within the network often exhibiting considerable heterogeneity in their intrinsic periods.
K L Nikhil, Sandra Korge, Achim Kramer
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Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue.
PLoS Genetics, 2012 The circadian regulatory network is organized in a hierarchical fashion, with a central oscillator in the suprachiasmatic nuclei (SCN) orchestrating circadian oscillations in peripheral tissues.
Michael E Hughes +7 more
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NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.
PLoS Genetics, 2016 Heterodimers of CLOCK and BMAL1 are the major transcriptional activators of the mammalian circadian clock. Because the paralog NPAS2 can substitute for CLOCK in the suprachiasmatic nucleus (SCN), the master circadian pacemaker, CLOCK-deficient mice ...
Dominic Landgraf +3 more
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Biologia Plantarum, 2018 Strawberry is an economically important fruit crop worldwide. Circadian clock genes are endogenous timers that regulate a wide range of metabolic processes and consequently plant development.
X. D. Chen, J. Wang, M. Z. Zhao, F. Zhao
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