Results 31 to 40 of about 402,265 (407)
Neoplasia: An International Journal for Oncology Research, 2015 Clock circadian regulator (CLOCK)/brain and muscle arnt-like protein-1 (BMAL1) complex governs the regulation of circadian rhythm through triggering periodic alterations of gene expression.
Ming Cui +5 more
doaj +1 more source
Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. [PDF]
, 2013 Posttranslational modifications play central roles in myriad biological pathways including circadian regulation. We employed a circadian proteomic approach to demonstrate that circadian timing of phosphorylation is a critical factor in regulating ...
Allen, Jasmina J +10 more
core +1 more source
Circadian Clocks and Metabolism [PDF]
, 2013 Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle.
Marcheva, Biliana +5 more
openaire +4 more sources
Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back [PDF]
, 2018 Clinical and research studies have suggested a link between Parkinson\u2019s disease (PD) and alterations in the circadian clock. Drosophila melanogaster may represent a useful model to study the relationship between the circadian clock and PD.
Bisaglia, Marco +3 more
core +1 more source
Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells. [PDF]
PLoS ONE, 2014 U2OS cells harbor a circadian clock but express only a few rhythmic genes in constant conditions. We identified 3040 binding sites of the circadian regulators BMAL1, CLOCK and CRY1 in the U2OS genome. Most binding sites even in promoters do not correlate
Julia Hoffmann +5 more
doaj +1 more source
p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. [PDF]
, 2013 The p75 neurotrophin receptor (p75(NTR)) is a member of the tumor necrosis factor receptor superfamily with a widespread pattern of expression in tissues such as the brain, liver, lung, and muscle.
Akassoglou, Katerina +7 more
core +2 more sources
Circadian clock protein Rev-erbα regulates neuroinflammation
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Disruptions in the circadian clock and its component proteins have been shown to be associated with disease states ranging from cancer to neurodegeneration.
Percy Griffin +14 more
semanticscholar +1 more source
Neuroimmunology of the circadian clock
Brain Research, 2008 Circadian timekeeping is a ubiquitous feature of all eukaryotes which allows for the imposition of a biologically appropriate temporal architecture on an animal's physiology, behavior and metabolism. There is growing evidence that in mammals the processes of circadian timing are under the influence of the immune system.
Coogan, Andrew, Wyse, Cathy A.
openaire +4 more sources
Mood phenotypes in rodent models with circadian disturbances
Neurobiology of Sleep and Circadian Rhythms, 2022 Many physiological functions with approximately 24-h rhythmicity (circadian rhythms) are generated by an internal time-measuring system of the circadian clock.
Kiyomichi Imamura, Toru Takumi
doaj
Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue.
PLoS Genetics, 2012 The circadian regulatory network is organized in a hierarchical fashion, with a central oscillator in the suprachiasmatic nuclei (SCN) orchestrating circadian oscillations in peripheral tissues.
Michael E Hughes +7 more
doaj +1 more source