Results 41 to 50 of about 47,618 (242)

Emerging roles for microRNA in the regulation of Drosophila circadian clock

BMC Neuroscience, 2018
Background The circadian clock, which operates within an approximately 24-h period, is closely linked to the survival and fitness of almost all living organisms. The circadian clock is generated through a negative transcription-translation feedback loop.
Yongbo Xue, Yong Zhang
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions

Frontiers in Molecular Neuroscience, 2021
The zebrafish represents a powerful model for exploring how light regulates the circadian clock due to the direct light sensitivity of its peripheral clocks, a property that is retained even in organ cultures as well as zebrafish-derived cell lines ...
Gennaro Ruggiero, Gennaro Ruggiero, Zohar Ben-Moshe Livne, Yair Wexler, Nathalie Geyer, Daniela Vallone, Yoav Gothilf, Yoav Gothilf, Nicholas S. Foulkes   +8 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Feeding and circadian clocks [PDF]

Reproduction Nutrition Development, 2006
The mammalian genome encodes at least a dozen of genes directly involved in the regulation of the feedback loops constituting the circadian clock. The circadian system is built up on a multitude of oscillators organized according to a hierarchical model in which neurons of the suprachiasmatic nuclei of the hypothalamus may drive the central circadian ...
Lissia, Pardini, Bertrand, Kaeffer
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans

Communications Biology
Animals have internal clocks that generate biological rhythms. In mammals, clock genes such as Period form the circadian clock to generate approximately 24-h biological rhythms. In C. elegans, the clock gene homologs constitute the “developmental clock”,
Shingo Hiroki, Hikari Yoshitane
doaj   +1 more source

The Molecular Circadian Clock and Alcohol-Induced Liver Injury

Biomolecules, 2015
Emerging evidence from both experimental animal studies and clinical human investigations demonstrates strong connections among circadian processes, alcohol use, and alcohol-induced tissue injury.
Uduak S. Udoh, Jennifer A. Valcin, Karen L. Gamble, Shannon M. Bailey   +3 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Effect of circadian clock disruption on type 2 diabetes

Frontiers in Physiology
IntroductionType 2 diabetes (T2D) is the predominant form of diabetes mellitus and is among the leading causes of death with an increasing prevalence worldwide. However, the pathological mechanism underlying T2D remains complex and unclear. An increasing
Hong Thuan Tran, Hong Thuan Tran, Takeru Kondo, Amal Ashry, Yunyu Fu, Hiroko Okawa, Chenphop Sawangmake, Chenphop Sawangmake, Chenphop Sawangmake, Hiroshi Egusa   +9 more
doaj   +1 more source