Results 41 to 50 of about 347,727 (386)
Mood phenotypes in rodent models with circadian disturbances
Neurobiology of Sleep and Circadian Rhythms, 2022 Many physiological functions with approximately 24-h rhythmicity (circadian rhythms) are generated by an internal time-measuring system of the circadian clock.
Kiyomichi Imamura, Toru Takumi
doaj
Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue.
PLoS Genetics, 2012 The circadian regulatory network is organized in a hierarchical fashion, with a central oscillator in the suprachiasmatic nuclei (SCN) orchestrating circadian oscillations in peripheral tissues.
Michael E Hughes +7 more
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PLoS Biology, 2020 A ubiquitous feature of the circadian clock across life forms is its organization as a network of cellular oscillators, with individual cellular oscillators within the network often exhibiting considerable heterogeneity in their intrinsic periods.
K L Nikhil, Sandra Korge, Achim Kramer
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Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells. [PDF]
PLoS ONE, 2014 U2OS cells harbor a circadian clock but express only a few rhythmic genes in constant conditions. We identified 3040 binding sites of the circadian regulators BMAL1, CLOCK and CRY1 in the U2OS genome. Most binding sites even in promoters do not correlate
Julia Hoffmann +5 more
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Circadian Clock Genes and the Transcriptional Architecture of the Clock Mechanism.
Journal of Molecular Endocrinology, 2018 The mammalian circadian clock has evolved as an adaptation to the 24-hour light/dark cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism (such as eating and sleeping) helps different tissue and organ systems ...
K. H. Cox, J. Takahashi
semanticscholar +1 more source
Biologia Plantarum, 2018 Strawberry is an economically important fruit crop worldwide. Circadian clock genes are endogenous timers that regulate a wide range of metabolic processes and consequently plant development.
X. D. Chen, J. Wang, M. Z. Zhao, F. Zhao
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Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock.
Cancer Discovery, 2019 Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells (GSCs). Here, we show that GSCs, differentiated glioblastoma cells (DGCs), and non-malignant brain cultures all displayed robust circadian rhythms, yet GSCs alone ...
Zhen Dong +19 more
semanticscholar +1 more source
Circadian Clocks: Evolution in the Shadows [PDF]
Current Biology, 2009 As scientists, we strive for highly controlled conditions. The real world, however, is noisy. Complex networks are a coping mechanism for an erratic environment.
Marc F.P.M. Maas, Martha Merrow
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Circadian Clock Regulates Inflammation and the Development of Neurodegeneration
Frontiers in Cellular and Infection Microbiology, 2021 The circadian clock regulates numerous key physiological processes and maintains cellular, tissue, and systemic homeostasis. Disruption of circadian clock machinery influences key activities involved in immune response and brain function.
Xiao-Lan Wang, Lianjian Li, Lianjian Li
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Radical pairs can explain magnetic field and lithium effects on the circadian clock [PDF]
arXiv, 2021 Drosophila's circadian clock can be perturbed by magnetic fields, as well as by lithium administration. Cryptochromes are critical for the circadian clock. Further, the radical pairs in cryptochrome also can explain magnetoreception in animals. Based on a simple radical pair mechanism model of the animal magnetic compass, we show that both magnetic ...
arxiv