Results 51 to 60 of about 402,265 (407)
Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]
, 2017 Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
core +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Circadian clocks are present in most cells of the body and act in concert to coordinate our daily physiology and behavior with the environment.
Gal Manella +6 more
semanticscholar +1 more source
Circadian and Circalunar Clock Interactions in a Marine Annelid
Cell Reports, 2013 Life is controlled by multiple rhythms. Although the interaction of the daily (circadian) clock with environmental stimuli, such as light, is well documented, its relationship to endogenous clocks with other periods is little understood.
Juliane Zantke +8 more
doaj +1 more source
Circadian Clock Proteins and Immunity [PDF]
Immunity, 2014 Immune parameters change with time of day and disruption of circadian rhythms has been linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow an organism to anticipate daily changes in activity and feeding and the associated risk of infection or tissue damage to the host. Responses to bacteria have been shown to vary
Curtis A. M. +3 more
openaire +5 more sources
Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer\u27s disease [PDF]
, 2020 A promising new therapeutic target for the treatment of Alzheimer\u27s disease (AD) is the circadian system. Although patients with AD are known to have abnormal circadian rhythms and suffer sleep disturbances, the role of the molecular clock in ...
Griffin, Percy +6 more
core +1 more source
Scientific Reports, 2018 Microbiota-derived short-chain fatty acids (SCFAs) and organic acids produced by the fermentation of non-digestible fibre can communicate from the microbiome to host tissues and modulate homeostasis in mammals.
Y. Tahara +9 more
semanticscholar +1 more source
Frontiers in Neuroscience, 2022 Accumulating evidence suggests that astrocytes, the abundant cell type in the central nervous system (CNS), play a critical role in maintaining the immune response after cerebral infarction, regulating the blood-brain barrier (BBB), providing nutrients ...
Yuxing Zhang +11 more
doaj +1 more source
Solving the mystery of human sleep schedules one mutation at a time. [PDF]
, 2013 Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui +2 more
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The choroid plexus is an important circadian clock component
Nature Communications, 2018 Mammalian circadian clocks have a hierarchical organization, governed by the suprachiasmatic nucleus (SCN) in the hypothalamus. The brain itself contains multiple loci that maintain autonomous circadian rhythmicity, but the contribution of the non-SCN ...
J. Myung +10 more
semanticscholar +1 more source
Circadian Clocks: Translation Lost [PDF]
Current Biology, 2005 One of the big questions in biological rhythms research is how a stable and precise circa-24 hour oscillation is generated on the molecular level. While increasing complexity seemed to be the key, a recent report suggests that circa-24 hour rhythms can be generated by just four molecules incubated in a test tube.
Martha Merrow, Till Roenneberg
openaire +2 more sources