In vitro and in vivo Phase Changes of the Mouse Circadian Clock by Oxidative Stress
Journal of Circadian Rhythms, 2016 Mammalian circadian rhythms are governed by an endogenous circadian clock system, including the molecular clock works in each cell and tissue. Adaptation of the circadian clock to different environmental stimuli such as light, food, and stress is ...
Yu Tahara +6 more
doaj +1 more source
A scenario of unhealthy life cycle: The role of circadian rhythms in health
Aging MedicineCircadian rhythms are oscillations in physiology and behavior caused by the circadian regulator. Cryptochromes, Periods, and Bmal1 are circadian clock genes that have been linked to aging and cancer.
Manasa Chandramouli +2 more
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Circadian clock control of Nox4 and reactive oxygen species in the vasculature. [PDF]
PLoS ONE, 2013 Recent studies have shown that circadian clock disruption is associated with pathological remodeling in the arterial structure and vascular stiffness.
Ciprian B Anea +10 more
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Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures [PDF]
, 2013 Circadian clocks exhibit ‘temperature compensation', meaning that they show only small changes in period over a broad temperature range. Several clock genes have been implicated in the temperature-dependent control of period in Arabidopsis.
Costa, Maria J. (Maria João) +13 more
core +5 more sources
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Evidence for widespread dysregulation of circadian clock progression in human cancer [PDF]
PeerJ, 2018 The ubiquitous daily rhythms in mammalian physiology are guided by progression of the circadian clock. In mice, systemic disruption of the clock can promote tumor growth. In vitro, multiple oncogenes can disrupt the clock.
Jarrod Shilts +2 more
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Role of Sleep Restriction in Daily Rhythms of Expression of Hypothalamic Core Clock Genes in Mice
Current Issues in Molecular Biology, 2022 Lack of sleep time is a menace to modern people, and it leads to chronic diseases and mental illnesses. Circadian processes control sleep, but little is known about how sleep affects the circadian system.
Weitian Li +4 more
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. [PDF]
PLoS ONE, 2012 Accumulating evidence suggests that the circadian clock is closely associated with metabolic regulation. However, whether an impaired circadian clock is a direct cause of metabolic dysregulation such as body weight gain is not clearly understood. In this
Hagoon Jang +5 more
doaj +1 more source
Rhythms of Locomotion Expressed by Limulus polyphemus, the American Horseshoe Crab: II. Relationship to Circadian Rhythms of Visual Sensitivity [PDF]
, 2008 In the laboratory, horseshoe crabs express a circadian rhythm of visual sensitivity as well as daily and circatidal rhythms of locomotion. The major goal of this investigation was to determine whether the circadian clock underlying changes in visual ...
Bedford, Lisa +2 more
core +3 more sources