Results 151 to 160 of about 336,986 (421)

Light and circadian regulation of clock components aids flexible responses to environmental signals [PDF]

, 2014
The circadian clock measures time across a 24h period, increasing fitness by phasing biological processes to the most appropriate time of day. The interlocking feedback loop mechanism of the clock is conserved across species; however, the number of loops
Akman, Ozgur E, Dixon, Laura E, Hodge, Sarah K, Millar, Andrew J, Troein, Carl, van Ooijen, Gerben   +5 more
core   +2 more sources

Advanced Microfluidic‐Based Wearable Electrochemical Sensors for Continuous Biochemical Monitoring

Advanced Electronic Materials, EarlyView.
Microfluidic‐based wearable electrochemical sensors are transforming non‐invasive health monitoring through real‐time biochemical analysis of sweat, saliva, and interstitial fluid. This review explores advances in microfluidic design, fabrication, and sensor integration while addressing biofluid variability, material compatibility, and scalability.
Sehyun Park, Seongyeop Kim, Soojin Lee, Vladimir V. Tsukruk, SeungHyun Park, Hyo‐Ryoung Lim   +5 more
wiley   +1 more source

Robustness of circadian clocks to daylight fluctuations: hints from the picoeucaryote Ostreococcus tauri [PDF]

, 2010
The development of systemic approaches in biology has put emphasis on identifying genetic modules whose behavior can be modeled accurately so as to gain insight into their structure and function.
A Goldbeter, A Goldbeter, Albert Goldbeter, AN Dodd, Benjamin Pfeuty, C Courties, C Troein, CS Pittendrigh, D Alabadi, D Gonze, D Rand, DA Rand, DB Forger, DGM Beersma, E Derelle, E Elowitz, E Hairer, F Corellou, F Geier, Florence Corellou, François-Yves Bouget, G Kurosawa, G Kurosawa, G Tiana, J Guckenheimer, J Moré, J Stricker, J Tomita, JC Leloup, JCW Locke, JCW Locke, JCW Locke, JD Salazar, L Ashall, L Rensing, LK Bognar, M Elowitz, M Merrow, M Moulager, MA Kramer, Marc Lefranc, MJ Chretiennot-Dinet, MN Zeilinger, N Barkai, NA Cookson, P Francois, P François, PE Morant, Pierre-Emmanuel Morant, Quentin Thommen, R Toth, S Panda, SR Taylor, TS Gardner, U Alon, W Mather, WW Wong, Y Ouyang, Y Shav-Tal   +58 more
core   +5 more sources

A Case of Prader‐Willi Syndrome With a Deletion Including MAGEL2, NDN, and MKRN3, but Excluding SNRPN and SNORD116

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Prader‐Willi syndrome (PWS) is a neurodevelopmental disorder typically caused by large deletions or imprinting defects on chromosome 15q11.2, encompassing multiple genes. While the contribution of individual genes to the PWS phenotype remains unclear, previous studies suggested that isolated deletions of MAGEL2, NDN, and MKRN3, excluding the ...
Jannis Buecking, Yu An, Weimin Bi, Katrin Hinderhofer, Susanne Theiß, Anne Slavotinek, Christian P. Schaaf   +6 more
wiley   +1 more source

Quantitative analysis of regulatory flexibility under changing environmental conditions [PDF]

, 2010
The circadian clock controls 24-h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops.
Adrian W Thomson, Alexandra Pokhilko, Andrew J Millar, David A Rand, Dunlap JC, Ferenc Nagy, Kieron D Edwards, Kirsten Knox, Laszlo Kozma‐Bognar, Ozgur E Akman, Paul E Brown, Peter J Lumsden, Thomas B   +12 more
core   +4 more sources

The mammalian circadian timing system: organization and coordination of central and peripheral clocks.

Annual Review of Physiology, 2010
Most physiology and behavior of mammalian organisms follow daily oscillations. These rhythmic processes are governed by environmental cues (e.g., fluctuations in light intensity and temperature), an internal circadian timing system, and the interaction ...
C. Dibner, U. Schibler, U. Albrecht
semanticscholar   +1 more source

Adverse Cardiovascular Risk Profile and Increased Diurnal Salivary Cortisol in Girls With Turner Syndrome: An Exploratory Study

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Patients with Turner Syndrome (TS) and those exposed to high concentrations of glucocorticoids have a number of characteristics in common, including an increased risk of cardiovascular disease. Pediatric TS patients underwent studies of salivary cortisol (SC) and cortisone (SCn), body composition, continuous glucose monitoring, vascular ...
Lily Jones, Julie Park, Silothabo Dliso, Daniel B. Hawcutt, Alena Shantsila, Gregory Y. H. Lip, Joanne Blair   +6 more
wiley   +1 more source

Seasonality and Light Phase-Resetting in the Mammalian Circadian Rhythm [PDF]

arXiv, 2019
We study the impact of light on the mammalian circadian system using the theory of phase response curves. Using a recently developed ansatz we derive a low-dimensional macroscopic model for the core circadian clock in mammals. Significantly, the variables and parameters in our model have physiological interpretations and may be compared with ...
arxiv  

Reflections On Contributing To “Big Discoveries” About The Fly Clock: Our Fortunate Paths As Post-Docs With 2017 Nobel Laureates Jeff Hall, Michael Rosbash, And Mike Young [PDF]

, 2018
In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate the period (per) gene, which was recovered in a revolutionary genetic screen by Ron Konopka and Seymour Benzer for mutants
Hardin, P. E., Price, J. L., Siwicki, Kathleen King   +2 more
core   +4 more sources

Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances

Animal Models and Experimental Medicine, EarlyView.
In this study, we classified postoperative patients into poor sleepers (PS) and good sleepers (GS) based on the bispectral index (BIS), and transplanted their fecal microbiota to pseudo‐germ‐free rats to analyze the sleep changes in rats and the potential mechanism.
Hui Zhong, Meiru Jiang, Kun Yuan, Fang Sheng, Xiuyun Xu, Yong Cui, Xijia Sun, Wenfei Tan   +7 more
wiley   +1 more source