Results 11 to 20 of about 342,113 (368)
Circadian clocks and breast cancer [PDF]
Breast Cancer Research, 2016 Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Victoria Blakeman +3 more
semanticscholar +4 more sources
Cellular mechano-environment regulates the mammary circadian clock [PDF]
Nature Communications, 2017 Circadian clocks regulate physiological and behavioural rhythms. Here, the authors show that the stiffness of the extracellular environment regulates circadian clocks in murine breast epithelium via Rho signalling, and explain how extracellular matrix ...
Nan Yang +10 more
doaj +2 more sources
Computational Analysis Predicts Hundreds of Coding lncRNAs in Zebrafish
Biology, 2021 Recent studies have demonstrated that numerous long noncoding RNAs (ncRNAs having more than 200 nucleotide base pairs (lncRNAs)) actually encode functional micropeptides, which likely represents the next regulatory biology frontier.
Shital Kumar Mishra, Han Wang
doaj +1 more source
Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster
eLife, 2022 Circadian clocks are highly conserved transcriptional regulators that control ~24 hr oscillations in gene expression, physiological function, and behavior.
Peter S Johnstone +6 more
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Circadian Biology: Clocks within Clocks [PDF]
Current Biology, 2005 A small cluster of approximately 20,000 neurons in the ventral hypothalamus provide the body with key time-keeping signals and drive circadian rhythms. This circadian clock exhibits surprisingly complex substructures, with inputs from the retina, and outputs to other brain structures.
Piggins, Hugh D., Loudon, Andrew
openaire +2 more sources
Circadian Clocks: Translation Lost [PDF]
Current Biology, 2005 One of the big questions in biological rhythms research is how a stable and precise circa-24 hour oscillation is generated on the molecular level. While increasing complexity seemed to be the key, a recent report suggests that circa-24 hour rhythms can be generated by just four molecules incubated in a test tube.
Roenneberg, T, Merrow, M
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A broken circadian clock: The emerging neuro-immune link connecting depression to cancer
Brain, Behavior, & Immunity - Health, 2022 Circadian clocks orchestrate daily rhythms in many organisms and are essential for optimal health. Circadian rhythm disrupting events, such as jet-lag, shift-work, night-light exposure and clock gene alterations, give rise to pathologic conditions that ...
Keyu Su +11 more
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Communicating clocks shape circadian homeostasis
Science, 2021 Regulating multiple body clocks Circadian rhythms that affect multiple tissues and organ systems are aligned with the dark-light cycle and other external inputs such as feeding.
K. Koronowski, P. Sassone-Corsi
semanticscholar +1 more source
New Insights Into Cancer Chronotherapies
Frontiers in Pharmacology, 2021 Circadian clocks participate in the coordination of various metabolic and biological activities to maintain homeostasis. Disturbances in the circadian rhythm and cancers are closely related.
Jingxuan Zhou +10 more
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Organoids as Model Systems to Investigate Circadian Clock-Related Diseases and Treatments
Frontiers in Genetics, 2022 Circadian rhythms exist in most cell types in mammals regulating temporal organization of numerous cellular and physiological processes ranging from cell cycle to metabolism.
Suengwon Lee, Christian I. Hong
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