Results 231 to 240 of about 31,091 (262)

CircRNA and Ageing

2023
Circular RNAs (circRNAs) are closed-loop RNA transcripts formed by a noncanonical back splicing mechanism. circRNAs are expressed in various tissues and cell types in a temporospatially regulated manner and have diverse molecular functions including their ability to act as miRNA sponges, transcriptional and splicing regulators, protein traps, and even ...
Ebrahim, Mahmoudi, Murray J, Cairns
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CircRNAs in diabetic cardiomyopathy

Clinica Chimica Acta, 2021
Diabetic cardiomyopathy is an important irreversible chronic cardiovascular complication in diabetic patients. This condition is described as early diastolic dysfunction, myocardial fibrosis, cardiac hypertrophy, systolic dysfunction and other complex pathophysiological events, which ultimately lead to heart failure.
Hengquan Wan, Simin Zhao, Qian Zeng, Yao Tan, Chi Zhang, Lingyun Liu, Shunlin Qu   +6 more
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CircRnas in atherosclerosis, with special emphasis on the spongy effect of circRnas on miRnas

Cell Cycle, 2022
Atherosclerosis (AS) is a chronic inflammatory disease, which leads to atherosclerotic rupture, lumen stenosis and thrombosis, and often endangers life. Circular RNAs (circRNAs) are a special class of non-coding RNA molecules, whose abnormal expression has been proved to be closely related to human diseases, including AS.
Chenglong Cheng, Yuting Wang, Qiuyun Xue, Yurong Huang, Xiao Wang, Faxue Liao, Chenggui Miao   +6 more
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CircRNAs and LncRNAs in Osteoporosis

Differentiation, 2020
Osteoporosis is a systemic bone disease with bone fragility and increased fracture risk. The non-coding RNAs (ncRNAs) have appeared as important regulators of cellular signaling and pertinent human diseases. Studies have demonstrated that circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) are involved in the progression of osteoporosis through
Tiantian He, Wei Liu, Lihua Cao, Ying Liu, Zi Zou, Yancheng Zhong, Haihua Wang, Yuqing Mo, Shuping Peng, Cijun Shuai   +9 more
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circRNA and gastrointestinal cancer

Journal of Cellular Biochemistry, 2019
AbstractCircular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs that form covalently closed continuous loops without 3′ end poly (A) tails and 5′ end caps. circRNAs are more conservative and stable than linear RNA. circRNAs can specifically bind to microRNAs as competing endogenous RNA, thereby directly or indirectly regulating the ...
Bing Luo, Chao‐ming Tang, Jing‐Song Chen   +2 more
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Dysregulation of circRNAs in rheumatoid arthritis, with special emphasis on circRNAs secreted by exosomes and the crosstalk between circRNAs and RNA methylations

International Immunopharmacology, 2023
Rheumatoid arthritis (RA) is an autoimmune disease caused by a variety of unknown factors. It mainly occurs in the small joints of hands and feet, leading to cartilage destruction and bone erosion. Various pathologic mechanisms such as exosomes and RNA methylations are involved in the pathogenesis of RA.This work searches PubMed, Web of Science (SCIE ...
Yuting Wang, Yurong Huang, Chenglong Cheng, Qiuyun Xue, Jun Chang, Xiao Wang, Qiangjun Duan, Chenggui Miao   +7 more
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Circular RNAs (circRNAs) in cancer

Cancer Letters, 2018
Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that circRNA has a regulatory effect on ...
Yumin Wang, Chunmei Fan, Yong Li
exaly   +3 more sources

Contribution of circRNAs in gastric cancer

Pathology - Research and Practice, 2021
Gastric cancer (GC) is one of the most commonly diagnosed neoplasms in the world. A number of environmental and lifestyle factors, particularly chronic infection with Helicobacter pylori, have been found to partake in the pathogenesis of GC. The advent of high-throughput genome and transcriptome analysis has enhanced the knowledge about molecular ...
Soudeh Ghafouri-Fard, Kasra Honarmand Tamizkar, Elena Jamali, Mohammad Taheri, Seyed Abdulmajid Ayatollahi   +4 more
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The new function of circRNA: translation

Clinical and Translational Oncology, 2020
Circular RNAs (circRNAs) have been considered a special class of non-coding RNAs without 5' caps and 3' tails which are covalently closed RNA molecules generated by back splicing of mRNA. For a long time, circRNAs have been considered to be directly involved in various biological processes as functional RNA.
Y. Shi, X. Jia, J. Xu
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Role of lncRNAs and circRNAs in epilepsy

Ageing Research Reviews, 2022
Epilepsy is a chronic disorder of with a high prevalence and extensive health burden in almost all age groups of the population. This condition is resulted from disturbance in the balance between excitatory and inhibitory factors in the brain. Genetic elements that affect synaptic connectivity, receptors functions or ion channels have been shown to ...
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Elena Jamali, Wojciech Branicki, Mohammad Taheri, Nader Akbari Dilmaghani   +5 more
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