Results 241 to 250 of about 36,533 (268)

CircRNAs in Plants

2018
Circular RNAs (circRNAs) are covalently closed, single-stranded transcripts that are ubiquitously expressed in all eukaryotes and even prokaryotic archaea. Although once regarded as splicing artifacts, circRNAs are a novel class of regulatory molecules with diverse biological functions, including regulation of transcription, modulation of alternative ...
Lai, Xuelei, Bazin, Jérémie, Webb, Stuart, Crespi, Martin, Zubieta, Chloe, Conn, Simon   +5 more
openaire   +4 more sources

circRNA and gastrointestinal cancer

Journal of Cellular Biochemistry, 2019
AbstractCircular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs that form covalently closed continuous loops without 3′ end poly (A) tails and 5′ end caps. circRNAs are more conservative and stable than linear RNA. circRNAs can specifically bind to microRNAs as competing endogenous RNA, thereby directly or indirectly regulating the ...
Bing Luo, Chao‐ming Tang, Jing‐Song Chen   +2 more
openaire   +2 more sources

Circular RNAs (circRNAs) in cancer

Cancer Letters, 2018
Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that circRNA has a regulatory effect on ...
Yumin Wang, Yong Li, Wei Xiong
exaly   +3 more sources

CRISPR–Cas13 targets circRNAs

Nature Reviews Genetics, 2020
The CRISPR–Cas13 system can be used to knock down circular RNAs (circRNAs) without any impact on related mRNAs, reports a study in Nature Methods.
openaire   +2 more sources

CircRNAs and LncRNAs in Osteoporosis

Differentiation, 2020
Osteoporosis is a systemic bone disease with bone fragility and increased fracture risk. The non-coding RNAs (ncRNAs) have appeared as important regulators of cellular signaling and pertinent human diseases. Studies have demonstrated that circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) are involved in the progression of osteoporosis through
Tiantian He, Wei Liu, Lihua Cao, Ying Liu, Zi Zou, Yancheng Zhong, Haihua Wang, Yuqing Mo, Shuping Peng, Cijun Shuai   +9 more
openaire   +2 more sources

CircRNA-mediated ceRNA mechanism in Osteoarthritis: Special emphasis on circRNAs in exosomes and the crosstalk of circRNAs and RNA methylation

Biochemical Pharmacology, 2023
Osteoarthritis (OA) is an age-related joint disease with chronic inflammation, progressive articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a class of non-coding RNA with a circular structure that participate in a series of important pathophysiological processes of OA, especially its ceRNA mechanisms, and play an ...
Qiuyun, Xue, Yurong, Huang, Jun, Chang, Chenglong, Cheng, Yuting, Wang, Xiaomei, Wang, Chenggui, Miao   +6 more
openaire   +2 more sources

Structure-Mediated Degradation of CircRNAs

Trends in Cell Biology, 2020
The elaborate control of biogenesis and turnover is essential for circular RNAs (circRNAs) to exert their functions properly in eukaryotic cells, whereas how circRNAs are degraded remains unclear. A recent study by Fischer et al. reveals a novel structure-mediated circRNA decay that selectively degrades highly structured RNAs by UPF1 and G3BP1.
Yingli, Guo, Xiawei, Wei, Yong, Peng
openaire   +2 more sources

Nonradioactive Northern Blot of circRNAs

2018
Circular RNAs (circRNAs) are recognized as a special species of transcripts in metazoans with increasing studies, and northern blotting is a direct way to confirm the existence and to evaluate the size of individual circRNAs. Northern blotting probes can be radioactive isotope (32P) labeled, which is not environment-friendly and sometimes inconvenient ...
Xiaolin, Wang, Ge, Shan
openaire   +2 more sources

CircRNA regulates lung cancer metastasis

Gene
Lung cancer stands prominently among the foremost contributors to human mortality, distinguished by its elevated fatality rate and the second-highest incidence rate among malignancies. The metastatic dissemination of lung cancer stands as a primary determinant of its elevated mortality and recurrence rates, underscoring the imperative for comprehensive
Han, Li, Fan, Wu, Yaqi, Han, Ziyi, Guo, Tangbing, Chen, Zhongliang, Ma   +5 more
openaire   +2 more sources

CircRNAs in cancer therapy tolerance

Clinica Chimica Acta
The rapidly expanding field of circular RNA (circ-RNA) research has opened new avenues in cancer diagnostics and treatment, highlighting the role of serum circRNAs as potential biomarkers for assessing tumor therapy resistance. This review comprehensively compiles existing knowledge regarding the biogenesis, function, and clinical relevance of circRNAs,
Miao He, Yunyan Pan, Chongge You, Hongwei Gao   +3 more
openaire   +2 more sources