Results 51 to 60 of about 251,975 (292)

Deciphering the preference and predicting the viability of circular permutations in proteins. [PDF]

PLoS ONE, 2012
Circular permutation (CP) refers to situations in which the termini of a protein are relocated to other positions in the structure. CP occurs naturally and has been artificially created to study protein function, stability and folding.
Wei-Cheng Lo, Tian Dai, Yen-Yi Liu, Li-Fen Wang, Jenn-Kang Hwang, Ping-Chiang Lyu   +5 more
doaj   +1 more source

Evolution of Circular Permutations in Multidomain Proteins [PDF]

Molecular Biology and Evolution, 2006
Modular rearrangements play an important role in protein evolution. Functional modules, often tantamount to structural domains or smaller fragments, are in many cases well conserved but reoccur in a different order and across many protein families. The underlying genetic mechanisms are gene duplication, fusion, and loss of sequence fragments.
January, Weiner, Erich, Bornberg-Bauer
openaire   +2 more sources

Calibration and standardisation of synchrotron radiation circular dichroism and conventional circular dichroism spectrophotometers [PDF]

, 2003
Synchrotron radiation circular dichroism (SRCD) is an emerging technique in structural biology with particular value in protein secondary structure analyses since it permits the collection of data down to much lower wavelengths than conventional ...
Wien, Frank, Wallace, Bonnie Ann, Rodger, Alison, Lees, Jonathan G., Miles, Andrew J.   +4 more
core  

Folding factors and partners for the intrinsically disordered protein Micro-Exon Gene 14 (MEG-14)

, 2013
The micro-exon genes (MEG) of Schistosoma mansoni, a parasite responsible for the second most widely spread tropical disease, code for small secreted proteins with sequences unique to the Schistosoma genera.
Orcia, Debora, Araujo, A.P.U., Wallace, Bonnie A., Araújo, Ana Paula Ulian de, De Marco, Ricardo, Araujo, Ana Paula U., Debora Orcia, Wallace, B. A., Lopes, Jose Luiz S., DeMarco, Ricardo, Lopes, J.L.S., Ricardo DeMarco, Ana Paula U. Araujo, Orcia, D., B.A. Wallace, Wallace, B.A., Jose Luiz S. Lopes, DeMarco, R.   +17 more
core   +1 more source

Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]

, 2005
MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga, Gabrijelcic-Geiger, Dusica, Le Nguyen, Dung, Schmoldt, H. U., Sommerhoff, Christian P., Kolmar, Harald, Gabrijelcic-Geiger, D., Le Nguyen, D., Schmoldt, Hans-Ulrich, Diederichsen, Ulf   +9 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Exploring Biosurfactant Production from Halophilic Bacteria, Isolated from Burgas Salterns in Bulgaria

Marine Drugs
Biosurfactants produced by halophilic bacteria are gaining attention as eco-friendly and biocompatible alternatives to synthetic surfactants due to their high surface activity, stability under extreme conditions, and intrinsic antimicrobial properties ...
Kaloyan Berberov, Ivanka Boyadzhieva, Boryana Yakimova, Hristina Petkova, Ivanka Stoineva, Lilyana Nacheva, Lyudmila Kabaivanova   +6 more
doaj   +1 more source

Stability and membrane orientation of the fukutin transmembrane domain: a combined multiscale molecular dynamics and circular dichroism study

, 2010
The N-terminal domain of Fukutin-I has been implicated in the localization of the protein in the endoplasmic reticulum/Golgi apparatus. It has been proposed to mediate this through its interaction with the thinner lipid bilayers found in these ...
Khalid, Syma, Thomas J. Piggot, Philip T. F. Williamson, Syma Khalid, Leung, Yuk Ming, Yuk Ming Leung, Daniel A. Holdbrook, Holdbrook, Daniel A., Piggot, T, Marius, Phedra, Williamson, Phillip T.F., Phedra Marius   +11 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Circular RNA in hepatocellular carcinoma: emerging therapeutic strategies

Frontiers in Immunology
Circular RNAs, or circRNAs, are unique single-stranded RNA molecules that form covalently closed circles. They possess a wide range of cellular functions and can act as tumor suppressors or promoters, regulating various aspects of carcinogenesis.
Gregor Jazbec, Tadeja Režen
doaj   +1 more source