Results 121 to 130 of about 169,673 (308)
Free circular introns with an unusual branchpoint in neuronal projections
, 2019 The polarized structure of axons and dendrites in neuronal cells depends in part on RNA localization. Previous studies have looked at which polyadenylated RNAs are enriched in neuronal projections or at synapses, but less is known about the distribution ...
Saini, Harleen +3 more
core +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
RNA methylation by NSUN4 marks mitochondrial double-stranded RNAs for degradation
, 2022 Human mitochondria have a compact circular genome that encodes 13 protein-coding genes as well as mitochondrial rRNAs and tRNAs. While most protein-coding genes are located in the heavy strand of the genome, the mitochondrial transcription occurs ...
Kim, Sujin +6 more
core
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Analysis of circZNF609: a multifunctional circular RNA with oncogenic properties
reservedCircular RNAs (circRNAs) are a peculiar class of stable RNAs that have a covalently closed loop structure originated from a noncanonical splicing event (back-splicing), characterized by the lack of 5’ and 3’ ends.
CONTE, EMMA
core
The Virtual Circular Genome Model for Primordial RNA Replication
, 2020 Our manuscript describes a hypothesis for the replication of primordial RNA genomes by entirely nonenzymatic processes. Our proposal circumvents long standing problems such as the difficulty of copying long templates by nonenzymatic chemistry, the need ...
Jack, Szostak, Lijun, Zhou, Dian, Ding
core +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Frontiers in Molecular MedicineN6-methyladenosine (m6A) is the best-studied post-transcriptional RNA modification. It refers to the methylation in the N6 position. M6A exists universally from viruses to mammalian cells and is highly abundant in RNA polymerase II-transcribed, protein ...
Heedoo Lee +3 more
doaj +1 more source
, 2019 Lin Yan,1 Min Zheng,1 Hua Wang2 1Department of Breast Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325000, China; 2Department of Neurosurgery, The First Affiliated Hospital of Wenzhou
Yan L, Zheng M, Wang H
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