Results 201 to 210 of about 44,285 (229)
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Diagnostic developments involving cell-free (circulating) nucleic acids
Clinica Chimica Acta, 2006The detection of circulating nucleic acids has long been explored for the non-invasive diagnosis of a variety of clinical conditions. In earlier studies, detection of circulating DNA has been investigated for the detection of various forms of cancer. Metastasis and recurrence in certain cancer types have been associated with the presence of high levels
Y M Dennis Lo
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Expert Review of Molecular Diagnostics, 2019
Introduction: Screening methods for one of the most frequently diagnosed malignancy, colorectal cancer (CRC), have limitations. Circulating cell-free nucleic acids (cfNA) hold clinical relevance as screening, prognostic and therapy monitoring markers.
Bela Molnár +2 more
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Introduction: Screening methods for one of the most frequently diagnosed malignancy, colorectal cancer (CRC), have limitations. Circulating cell-free nucleic acids (cfNA) hold clinical relevance as screening, prognostic and therapy monitoring markers.
Bela Molnár +2 more
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Circulating cell-free nucleic acids as biomarkers in colorectal cancer screening and diagnosis
Expert Review of Molecular Diagnostics, 2016Screening methods for the most frequent diagnosed malignant tumor, colorectal cancer (CRC), have limitations. Circulating cell-free DNA (cfDNA) analysis came into focus as a potential screening test for CRC. Detection of epigenetic and genetic alterations of cfDNA as DNA methylation or DNA mutations and related ribonucleic acids may improve cancer ...
Kinga Tóth +2 more
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2010
Fragmented DNA and RNA circulate as cell-free nucleic acids in plasma, serum, urine and other body fluids. Access to these molecules for analysis may allow for detection of certain disease states based on a blood sample. In this study the extraction efficiency of a large volume nucleic acid extraction kit for circulating and viral nucleic acids was ...
Markus Sprenger-Haussels +1 more
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Fragmented DNA and RNA circulate as cell-free nucleic acids in plasma, serum, urine and other body fluids. Access to these molecules for analysis may allow for detection of certain disease states based on a blood sample. In this study the extraction efficiency of a large volume nucleic acid extraction kit for circulating and viral nucleic acids was ...
Markus Sprenger-Haussels +1 more
exaly +2 more sources
Expert Opinion on Biological Therapy, 2012
Extracellular nucleic acids are found in human blood and cell culture medium as cell-free or being adsorbed at cell surface. In the last years, the circulating extracellular nucleic acids in blood were shown to be associated with certain diseases.
Elena Y Rykova +2 more
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Extracellular nucleic acids are found in human blood and cell culture medium as cell-free or being adsorbed at cell surface. In the last years, the circulating extracellular nucleic acids in blood were shown to be associated with certain diseases.
Elena Y Rykova +2 more
exaly +3 more sources
Circulating Tumor Cells and Cell-free Nucleic Acids as Biomarkers in Colorectal Cancer
Current Pharmaceutical Design, 2023Abstract: Colorectal cancer (CRC) is currently the second most prevalent cancer diagnosed in women and the third most common kind of cancer in men. Despite tremendous efforts and advancements in diagnostic approaches and treatment options, the mortality rate of CRC accounts for around one million each year globally.
Ghazaleh, Pourali +9 more
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Circulating Cell-Free Nucleic Acids: Promising Biomarkers of Hepatocellular Carcinoma
Seminars in Oncology, 2012Hepatocellular carcinoma (HCC) is considered to be a fatal disease because of its late diagnosis, underlying liver disease, and refractoriness to systemic treatments. Biomarkers with high sensitivity and specificity that are minimally invasive, reproducible, and easily available have important clinical utility for early diagnosis, prognostication, and ...
Jian, Zhou, Ying-Hong, Shi, Jia, Fan
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Environmental Science and Pollution Research, 2022
Radiology workers might constantly be exposed to low-dose ionizing radiation due to their profession. Low doses of radiation in a short exposure time have the potential to alter the genome, which might potentially lead to diseases. The main objective of this study was to determine whether the amount of cell-free nucleic acids in plasma samples of ...
KILINÇ, NİHAL +2 more
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Radiology workers might constantly be exposed to low-dose ionizing radiation due to their profession. Low doses of radiation in a short exposure time have the potential to alter the genome, which might potentially lead to diseases. The main objective of this study was to determine whether the amount of cell-free nucleic acids in plasma samples of ...
KILINÇ, NİHAL +2 more
openaire +3 more sources
Fetal Cell‐Free Nucleic Acids in the Maternal Circulation: New Clinical Applications
Annals of the New York Academy of Sciences, 2004Abstract: Six years after the demonstration of the presence of cell‐free fetal nucleic acids in maternal plasma, perinatal clinical applications continue to expand. The focus of this article is on advances that have occurred since the CNAPS II conference held in Hong Kong in 2001.
Tuangsit, Wataganara, Diana W, Bianchi
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