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Cell free circulating tumor nucleic acids, a revolution in personalized cancer medicine
Critical Reviews in Oncology/Hematology, 2019Innovative diagnostics are becoming an essential component in personalized cancer medicine. These diagnostics are increasingly based on cell-free nucleic acids and membrane vesicles. Isolating and sequencing cell free circulating DNA (cfDNA) in plasma may progressively substitute tumor biopsies.
Kerachian, Mohammad Amin +2 more
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Relationship Between Cardiovascular Diseases and Circulating Cell-Free Nucleic Acids in Human Plasma
Biomarkers in Medicine, 2018Cardiovascular diseases (CVDs) are the main cause of human morbidity and mortality worldwide. Early diagnosis could improve the efficiency of treatments. New biomarkers are needed for the identification of high-risk populations in order to make accurate diagnosis and therapy monitoring. Circulating cell-free nucleic acids (cf-NAs) offer a promising new
Orsolya, Biró +5 more
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Circulating tumor cells and cell-free nucleic acids in patients with gynecological malignancies
Virchows Archiv, 2018The ability to detect cancer cells in the blood or in the bone marrow offers invaluable information which potentially impacts early diagnosis, monitoring of treatment, and prognosis. Accessing blood or other body fluids has the additional advantage of being less invasive than biopsy.
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Molecular Detection of Circulating Tumor Cells and Cell-Free Nucleic Acids
2016One of the key roles performed by pathologists is determination of the presence or absence of tumor in clinical samples. This is the basis for most approaches to staging, monitoring response to treatment, and detecting relapse of neoplasia and, as such, is a critical step in determining the course of patient management.
Nirali M. Patel, Karen Kaul
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Circulating cell free nucleic acids as a tool for assessment of patients with sepsis
2020Sepsis is one of the major causes of in-hospital mortality. There is no specific treatment for sepsis and the management relies on early diagnosis and in-time prognosis. However, presently there still lack accurate methods to detect infection and organ dysfunction, two major factors define sepsis.
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Obstetrical & Gynecological Survey, 2011
The objective of the study was the evaluation of a novel multiplex assay to detect fetal Rh blood group D-antigen gene (RHD) loci in maternal plasma from RhD-negative, pregnant women.An RHD genotyping assay was designed to detect exons 4, 5, 7, and 10 and RHDΨ (pseudogene) of the RHD gene along with a Y chromosome-specific assay and a generic ...
John A, Tynan +5 more
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The objective of the study was the evaluation of a novel multiplex assay to detect fetal Rh blood group D-antigen gene (RHD) loci in maternal plasma from RhD-negative, pregnant women.An RHD genotyping assay was designed to detect exons 4, 5, 7, and 10 and RHDΨ (pseudogene) of the RHD gene along with a Y chromosome-specific assay and a generic ...
John A, Tynan +5 more
openaire +2 more sources
Lung Cancer, 2017
Lung cancer is the predominant cause of cancer-related mortality in the world. The majority of patients present with locally advanced or metastatic non-small-cell lung cancer (NSCLC). Treatment for NSCLC is evolving from the use of cytotoxic chemotherapy to personalized treatment based on molecular alterations.
L, Sorber +7 more
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Lung cancer is the predominant cause of cancer-related mortality in the world. The majority of patients present with locally advanced or metastatic non-small-cell lung cancer (NSCLC). Treatment for NSCLC is evolving from the use of cytotoxic chemotherapy to personalized treatment based on molecular alterations.
L, Sorber +7 more
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