Results 21 to 30 of about 253,295 (266)
Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro [PDF]
PLoS Comput Biol 10(8): e1003774, 2014, 2013 In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an extracellular matrix, endothelial cells can form blood vessel-like structures, including vascular networks and sprouts.
arxiv +1 more source
Neural Regeneration Research, 2019 Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their function. However, the relationship between blood glucose levels and endothelial progenitor cells in peripheral blood of patients
Hui-Jie Wei +9 more
doaj +1 more source
Deciphering the relative contribution of vascular inflammation and blood rheology in metastatic spreading [PDF]
Biomicrofluidics 12.4 (2018), p. 042205. doi: 10.1063/1.5022879.
eprint: https://doi.org/10.1063/1. 5022879. url:
https://doi.org/10.1063/1.5022879, 2018 Vascular adhesion of circulating tumor cells (CTCs) is a key step in cancer spreading. If inflammation is recognized to favor the formation of vascular metastatic niches, little is known about the contribution of blood rheology to CTC deposition. Herein, a microfluidic chip, covered by a confluent monolayer of endothelial cells, is used for analyzing ...
arxiv +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Circulating microparticles have emerged as biomarkers and effectors of vascular disease. Elevated rates of cardiovascular disease are seen in HIV‐1–seropositive individuals.
Jamie G. Hijmans +9 more
doaj +1 more source
Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell Permeability Downstream from G{alpha}12/13 and G{alpha}11/q [PDF]
The Journal of Biological Chemistry 283, 44 (2008) 29888-96, 2008 Increase in vascular permeability occurs under many physiological conditions and is central in diverse human pathologies. Thrombin is a pro-coagulant serine protease, which causes the local loss of endothelial barrier integrity thereby enabling the rapid extravasation of plasma proteins and the local formation of fibrin-containing clots.
arxiv +1 more source
Breaking the VE-cadherin bonds [PDF]
FEBS Letters / FEBS-Letters; FEBS Microbiol Lett (2008) epub ahead
of print, 2008 Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. Indeed, a growing number of permeability inducing
arxiv +1 more source
Bio-Protocol, 2016 Hematogenous metastasis is a primary cause of mortality from metastatic cancer. The shear-resistant adhesion of circulating tumor cells to the vascular endothelial cell surface under blood flow is an essential step in cell extravasation and further ...
Shin-Ae Kang +2 more
doaj +1 more source
Finite element simulation of the structural integrity of endothelial cell monolayers: a step for tumor cell extravasation [PDF]
, 2019 Cell extravasation is a crucial step of the metastatic cascade. In this process, the circulating tumor cells inside the blood vessels adhere to the cell monolayer of the blood vessel wall and passes through it, which allows them to invade different organs and complete metastasis.
arxiv +1 more source
VE-cadherin and claudin-5: it takes two to tango [PDF]
Nat Cell Biol 10, 8 (2008) 883-5, 2008 Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and -catenin, which repress the claudin-5 promoter.
arxiv +1 more source
Efficient Uncertainty Quantification in a Multiscale Model of Pulmonary Arterial and Venous Hemodynamics [PDF]
, 2023 Computational hemodynamics models are becoming increasingly useful in the management and prognosis of complex, multiscale pathologies, including those attributed to the development of pulmonary vascular disease. However, diseases like pulmonary hypertension are heterogeneous, and affect both the proximal arteries and veins as well as the ...
arxiv +1 more source