Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis [PDF]
, 2010 Chemerin acting via its distinct G protein-coupled receptor CMKLR1 (ChemR23), is a novel adipokine, circulating levels of which are raised in inflammatory states.
Randeva, Harpal S. +4 more
core +1 more source
Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. [PDF]
PLoS ONE, 2013 Mesenchymal stem cells natively circulating or delivered into the blood stream home to sites of injury. The mechanism of mesenchymal stem cell homing to sites of injury is poorly understood.
Irina A Potapova +2 more
doaj +1 more source
Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells [PDF]
, 2003 Background— Transplantation of ex vivo expanded circulating endothelial progenitor cells (EPCs) from peripheral blood mononuclear cells improves the neovascularization after critical ischemia. However, the origin of the endothelial progenitor lineage and
Dimmeler, S +5 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Circulating Endothelial Cells in Vasculitis and Transplantation [PDF]
Pathophysiology of Haemostasis and Thrombosis, 2003 Damage to microvascular endothelial cells is the hallmark of small-vessel vasculitis. Based on the histology, however, an intriguing question has long been unanswered: Given that cells undergo detachment from the basement, what happens to these cells and can we detect them in peripheral blood? Moreover, it seemed reasonable to assume that the number of
openaire +2 more sources
Circulating endothelial cells demonstrate an attenuation of endothelial damage by minimizing the extracorporeal circulation [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2006 Detachment of endothelial cells may represent serious injury of the endothelium after cardiopulmonary bypass. We investigated whether the extent of endothelial injury is related to the type of cardiopulmonary bypass system used (conventional or minimized) and determined circulating endothelial cells as well as von Willebrand factor and soluble ...
Skrabal, Christian A. +6 more
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Maximal Exercise Improves the Levels of Endothelial Progenitor Cells in Heart Failure Patients
Current Issues in Molecular Biology, 2023 The impact of exercise on the levels of endothelial progenitor cells (EPCs), a marker of endothelial repair and angiogenesis, and circulating endothelial cells (CECs), an indicator of endothelial damage, in heart failure patients is largely unknown. This
Suiane Cavalcante +10 more
doaj +1 more source
Endothelial injury and repair in vasculitis of the young [PDF]
, 2009 The vasculitides are a wide spectrum of disorders which are characterised by vascular inflammation. Endothelial injury can occur as a consequence of inappropriate inflammation and is central to the pathogenesis of these varied diseases.
Clarke, L.
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source