Results 41 to 50 of about 253,295 (266)

Two channel compartmentalized microfluidic chip for real time monitoring of the metastatic cascade [PDF]

, 2019
Metastases are the primary cause of death in cancer patients. Small animal models are helping in dissecting some of key features in the metastatic cascade. Yet, tools for systematically analyze the contribution of blood flow, vascular permeability, inflammation, tissue architecture, and biochemical stimuli are missing. In this work, a microfluidic chip
arxiv   +1 more source

Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis

Acta Pharmaceutica Sinica B, 2023
METRNL is a recently identified secreted protein with emerging functions. This study is to find major cellular source of circulating METRNL and to determine METRNL novel function.
Sili Zheng, Zhiyong Li, Jie Song, Pin Wang, Jian Xu, Wenjun Hu, Yi Shi, Qi Qi, Zhuwei Miao, Yunfeng Guan, Chaoyu Miao   +10 more
doaj  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Pattern formation of elliptic particles by two-body interactions: a model for dynamics of endothelial cells in angiogenesis [PDF]

arXiv, 2022
A two-dimensional mathematical model for dynamics of endothelial cells in angiogenesis is investigated. Angiogenesis is a morphogenic process in which new blood vessels emerge from an existing vascular network. Recently a one-dimensional discrete dynamical model has been proposed to reproduce elongation, bifurcation, and cell motility such as cell ...
arxiv  

Detection of Abundant Non-Haematopoietic Circulating Cancer-Related Cells in Patients with Advanced Epithelial Ovarian Cancer

Cells, 2019
Background: Current diagnosis and staging of advanced epithelial ovarian cancer (aEOC) has important limitations and better biomarkers are needed.
Juhi Kumar, Dimple Chudasama, Charlotte Roberts, Mikael Kubista, Robert Sjöback, Jayanta Chatterjee, Vladimir Anikin, Emmanouil Karteris, Marcia Hall   +8 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Modeling iPSC-derived Endothelial Cell Transition in Tumor Angiogenesis using Petri Nets [PDF]

Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOINFORMATICS, 337-346, 2024
Tumor angiogenesis concerns the development of new blood vessels supplying the necessary nutrients for the further development of existing tumor cells. The entire process is complex, involving the production and consumption of chemicals, endothelial cell transitions as well as cell interactions, divisions, and migrations.
arxiv   +1 more source

Beneficial influence of low-density lipoprotein cholesterol on the endothelium in relation to endothelial repair

Environmental Health and Preventive Medicine
Background: Low-density lipoprotein cholesterol (LDLc) is regarded as a risk factor for endothelial dysfunction. However, LDLc stimulates the proliferation of hematopoietic stem cells (CD34-positive cells), which contribute to endothelial repair ...
Yuji Shimizu, Shin-Ya Kawashiri, Hirotomo Yamanashi, Seiko Nakamichi, Naomi Hayashida, Yasuhiro Nagata, Takahiro Maeda   +6 more
doaj   +1 more source

ELEVATED CIRCULATING ENDOTHELIAL CELLS AND SUCCESS IN ENDOTHELIAL COLONY-FORMING CELLS ISOLATION

Hematology, Transfusion and Cell Therapy, 2021
Introduction: Circulating endothelial cells (CEC) have been associated with vascular injury and are described as potential biomarkers for cardiovascular disease (1).
LQ Silva, AS Justo-Junior, SAL Montalvão, R Medina, JM Annichino-Bizzacchi   +4 more
doaj  

Endothelial Repair in Childhood Arterial Ischaemic Stroke with Cerebral Arteriopathy

Cerebrovascular Diseases Extra, 2015
Background: We have previously shown that recurrent arterial ischaemic stroke (AIS) in children with cerebral arteriopathy is associated with increased circulating endothelial cells and endothelial microparticles, consistent with ongoing endothelial ...
Despina Eleftheriou, Vijeya Ganesan, Ying Hong, Nigel J. Klein, Paul A. Brogan   +4 more
doaj   +1 more source