Results 81 to 90 of about 5,384,793 (288)

eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. [PDF]

, 2012
All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme directly catalyse superoxide formation ...
Sabine Grüner, Ostermeier Eva, Ostermeier, Eva, Bernhard Nieswandt, Huang Paul L., Angelika Schröttle, Georg Ertl, Ertl, Georg, Ulrich Hoffmann, Peter J Kuhlencordt, Kuhlencordt Peter J., Huang, Paul, Nieswandt Bernhard, Schröttle Angelika, Grüner, Sabine, Huang, Paul L., Paul L Huang, Ponnuswamy, Padmapriya, Schröttle, Angelika, Ertl Georg, Hoffmann Ulrich, Hoffmann, Ulrich, Padmapriya Ponnuswamy, Nieswandt, Bernhard, Grüner Sabine, Ponnuswamy Padmapriya, Kuhlencordt, Peter J., Eva Ostermeier   +27 more
core   +2 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Mean difference in endothelial progenitor cells and circulating endothelial cells by COPD severity.

, 2017
Mean difference in endothelial progenitor cells and circulating endothelial cells by COPD severity.
Russell P. Tracy (127552), Katja Hueper (185428), Jens Vogel-Claussen (313462), Margaret F. Doyle (449942), Megha A. Parikh (3836458), Karol Watson (405670), Steven Kawut (3836449), Daichi Shimbo (301599), Joao Lima (235647), R. Graham Barr (109958), Eric A. Hoffman (109953), Antoinette Gomes (3836455), Benjamin M. Smith (3836452), John H. M. Austin (546978)   +13 more
core   +1 more source

High calcium bioglass enhances differentiation and survival of endothelial progenitor cells, inducing early vascularization in critical size bone defects [PDF]

, 2013
Early vascularization is a prerequisite for successful bone healing and endothelial progenitor cells (EPC), seeded on appropriate biomaterials, can improve vascularization.
Marzi, Ingo, Eldesoqi, Karam, Christoph Nau, Schaible, Alexander, Dirk Henrich, Karam Eldesoqi, Alexander Schaible, Ngoc, Christina Nguyen, Christina Nguyen Ngoc, Henrich, Dirk, Ingo Marzi, Seebach, Caroline, Nau, Christoph, Caroline Seebach, Simon Meier, Meier, Simon, Schaible Alexander, Meier Simon, Henrich Dirk, Eldesoqi Karam, Seebach Caroline, Marzi Ingo, Nguyen Ngoc Christina, Nau Christoph   +23 more
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Distinct kinin-induced functions are altered in circulating cells of young type 1 diabetic patients. [PDF]

PLoS ONE, 2010
We aimed to understand early alterations in kinin-mediated migration of circulating angio-supportive cells and dysfunction of kinin-sensitive cells in type-1 diabetic (T1D) patients before the onset of cardiovascular disease.Total mononuclear cells (MNC)
Nicolle Kränkel, Stephen Paul Armstrong, Craig Alexander McArdle, Colin Dayan, Paolo Madeddu   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source