Results 1 to 10 of about 2,068,901 (353)

Using single-cell sequencing technology to detect circulating tumor cells in solid tumors

Molecular Cancer, 2021
Circulating tumor cells are tumor cells with high vitality and high metastatic potential that invade and shed into the peripheral blood from primary solid tumors or metastatic foci.
Jiasheng Xu, Kaili Liao, Xi Yang, Chengfeng Wu, Wei Wu, Shuwen Han   +5 more
doaj   +2 more sources

Circulating tumor cell profiling for precision oncology

Molecular Oncology, 2021
Analysis of circulating tumor cells (CTCs) collected from patient's blood offers a broad range of opportunities in the field of precision oncology. With new advances in profiling technology, it is now possible to demonstrate an association between the ...
Mahmoud Labib, Shana O. Kelley
doaj   +2 more sources

Circulating Tumor Cell Detection for Therapeutic and Prognostic Roles in Breast Cancer [PDF]

Cancer Medicine
Background Circulating tumor cells (CTCs) are pivotal liquid biopsy (LB) biomarkers for breast cancer (BC), offering non‐invasive insights into tumor progression and metastasis.
Saiying Ma, Xiaojia Wang, Peter Ping Lin, Lei Lei   +3 more
doaj   +2 more sources

Macrovascular tumor infiltration and circulating tumor cell cluster dynamics in patients with cancer approaching the end of life. [PDF]

Nat Med
Newcomer K, Bifolco A, Reeves S, Pontecorvi G, Asawa S, Sznurkowska MK, Nüesch M, Ozimski LL, Bolm L, Sieren MM, Müller L, Chi Z, Gasper W, Wachsmann MB, Moore W, Zheng X, Fokkema A, Ring A, Nguyen-Sträuli BD, Budinjas S, Ten Winkel M, Färber B, Zaki A, Fatimah N, Crecca E, Karalis JD, Chandra R, Prince H, Goff KL, Choi SH, Abousaab C, Zhang S, Cole S, Naumann K, Keck T, Polanco PM, Gvozdenovic A, Krol I, Castro-Giner F, Arteaga C, Zeh HJ, Kloeckner R, Ghersi D, Aceto N, Ligorio M.   +44 more
europepmc   +2 more sources

Recent Advances in Methods for Circulating Tumor Cell Detection

International Journal of Molecular Sciences, 2023
Circulating tumor cells (CTCs) are released from primary tumors and transported through the body via blood or lymphatic vessels before settling to form micrometastases under suitable conditions.
Monika Vidlařová, Alona Řehulková, Pavel Stejskal, Andrea Prokopova, H. Slavík, M. Hajdůch, J. Srovnal   +6 more
semanticscholar   +1 more source

Evaluation of Monocarboxylate Transporter 4 (MCT4) Expression and Its Prognostic Significance in Circulating Tumor Cells From Patients With Early Stage Non-Small-Cell Lung Cancer

Frontiers in Cell and Developmental Biology, 2021
Purpose: Monocarboxylate transporter 4 (MCT4) can influence the amount of lactate in the tumor microenvironment and further control cancer cell proliferation, migration, and angiogenesis.
Athina Markou, E. Tzanikou, G. Kallergi, E. Pantazaka, V. Georgoulias, A. Kotsakis, E. Lianidou   +6 more
doaj   +1 more source

StarDist Image Segmentation Improves Circulating Tumor Cell Detection

Cancers, 2022
Simple Summary Automated enumeration of circulating tumor cells (CTC) from immunofluorescence images starts with a selection of areas containing potential CTC.
M. Stevens, A. Nanou, L. Terstappen, C. Driemel, N. Stoecklein, F. Coumans   +5 more
semanticscholar   +1 more source

Comprehensive liquid biopsy analysis as a tool for the early detection of minimal residual disease in breast cancer

Scientific Reports, 2023
Liquid biopsy (LB) provides a unique minimally invasive tool to follow-up cancer patients over time, to detect minimal residual disease (MRD), to study metastasis-biology and mechanisms of therapy-resistance.
Dimitra Stergiopoulou, Athina Markou, Areti Strati, Martha Zavridou, Eleni Tzanikou, Sophia Mastoraki, Galatea Kallergi, Vassilis Georgoulias, Evi Lianidou   +8 more
doaj   +1 more source

PD-L1/pS6 in Circulating Tumor Cells (CTCs) during Osimertinib Treatment in Patients with Non-Small Cell Lung Cancer (NSCLC)

Biomedicines, 2022
The PD-1/PD-L1 axis provides CTCs an escape route from the immune system. Phosphorylation of the ribosomal protein S6 is implicated in the same pathway, following mTOR activation. The aim of the study was to investigate the expression of PD-L1 and pS6 in
Evangelia Pantazaka, Aliki Ntzifa, Argyro Roumeliotou, Evi Lianidou, Vassilis Georgoulias, Athanasios Kotsakis, Galatea Kallergi   +6 more
doaj   +1 more source

Gene expression in circulating tumor cells reveals a dynamic role of EMT and PD-L1 during osimertinib treatment in NSCLC patients

Scientific Reports, 2021
Liquid biopsy is a tool to unveil resistance mechanisms in NSCLC. We studied changes in gene expression in CTC-enriched fractions of EGFR-mutant NSCLC patients under osimertinib.
Aliki Ntzifa, Areti Strati, Galatea Kallergi, Athanasios Kotsakis, Vassilis Georgoulias, Evi Lianidou   +5 more
doaj   +1 more source