Results 131 to 140 of about 6,850,236 (255)

Deterministic separation of cancer cells from blood at 10 mL/min

AIP Advances, 2012
Circulating tumor cells (CTCs) and circulating clusters of cancer and stromal cells have been identified in the blood of patients with malignant cancer and can be used as a diagnostic for disease severity, assess the efficacy of different treatment ...
Kevin Loutherback, Joseph D'Silva, Liyu Liu, Amy Wu, Robert H. Austin, James C. Sturm   +5 more
doaj   +1 more source

Rational Control of Antibody Orientation for Enhancing Sensitivity and Specificity in Lateral Flow Immunoassays With Clinical Validation

Advanced Healthcare Materials, EarlyView.
Systematic investigation of antibody orientation strategies in lateral flow immunoassays reveals that a para‐substituted (aminomethyl)phenylboronic acid mediated probe (P‐6) combined with a biotin‐streptavidin test‐line modification achieves a synergistic 14‐ to 19‐fold sensitivity gain over conventional conjugation. Furthermore, multiplexed detection,
Pin‐Hao Wang, Shunmuga Nathan Shunmuga Nainar, Bing‐Han Zhuang, Shun‐Mao Yang, Hong‐Cheu Lin, Yang‐Hsiang Chan   +5 more
wiley   +1 more source

Circulating tumor cell detection and patient stay on treatment time.

, 2013
Circulating tumor cell detection and patient stay on treatment time.
Philip Z. Brohawn (448864), Laura K. Richman (448870), Robert J. Lechleider (448865), Xiaoru Chen (448863), Manuela Buzoianu (448867), Haifeng Bao (448861), Jiaqi Huang (79038), Theresa M. LaVallee (448871), Yihong Yao (94559), Jianliang Zhang (448868), Patricia A. Burke (448862), Robert S. Sikorski (448866), Xiaoqing Shi (448869)   +12 more
core   +1 more source

Modeling Early Metastatic Progression in Breast Cancer Using a Barrier‐Free, Perfusable Spheroid‐on‐a‐Chip Platform

Advanced Healthcare Materials, EarlyView.
Open‐port, barrier‐free microfluidic device for modeling early metastatic progression. A centrally positioned tumor spheroid releases invasive cells that migrate through the surrounding matrix and intravasate into endothelialized lateral channels.
Vira Sharko, Claudia Olaizola‐Rodrigo, Clara Bayona, Teodora Ranđelović, Rosa Monge, Estela Solanas, Sara Oliván, Ignacio Ochoa   +7 more
wiley   +1 more source

Phase Engineering of Nanomaterials (PEN): Evolution, Current Challenges, and Future Opportunities

Advanced Materials, EarlyView.
This review summarizes the synthesis, phase transition, advanced characterization spanning ex situ to in situ and operando techniques, and diverse applications of phase engineering of nanomaterials (PEN). It further outlines key challenges and future opportunities, such as phase stability, architecture control, and artificial intelligence (AI)‐driven ...
Ye Chen, Zhanxi Fan, Jingjie Ge, Qiyuan He, Zhuangchai Lai, Jiawei Liu, Chaoliang Tan, Hua Zhang   +7 more
wiley   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Evaluation of circulating tumor cell clusters for pan-cancer noninvasive diagnostic triaging. [PDF]

Cancer Cytopathol, 2021
Gaya A, Crook T, Plowman N, Ranade A, Limaye S, Bhatt A, Page R, Patil R, Fulmali P, Datta V, Kumar P, Patil D, Akolkar D.   +12 more
europepmc   +1 more source

Abstract 5895: Circulating CAF and cCAF circulating tumor cell co clusters are associated with metastatic breast cancer

, 2017
Background: Breast cancer metastasis is the cause of breast cancer-related mortality. The tumor microenvironment (TME) plays a critical role in governing tumor initiation, progression and metastasis. In breast cancer, cancer associated fibroblasts (CAFs)
Kelsie Medina-Saenz, Utsav Sharma, Philip Miller, Dorraya El-Ashry, Pedro Ferrer, Svetlana Speransky, Toni Yeasky   +6 more
core   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis

Cell Death and Disease
Breast cancer brain metastasis (BCBM) is a major cause of breast cancer-related mortality, but the molecular mechanisms underlying its progression remain poorly understood.
Haoyuan Shi, Jiaxin Chen, Zisheng Wu, Dong-Xu Liu, Jinmei Zhou, Xuexue Wu, Ailing Yang, Shanhu Li, Yanhong Tai, Zefei Jiang, Zhiyuan Hu, Mingshan Zhang, Xiaojie Xu, Lu Pan, Tao Wang   +14 more
doaj   +1 more source