Results 21 to 30 of about 6,225,689 (197)

Liquid Biopsy: Past, Present, and Future. [PDF]

MedComm (2020)
Liquid biopsy has expanded from cancer genotyping to a broader strategy for probing both oncologic and nononcologic conditions through circulating analytes and multilayer molecular readouts. This review traces the field's past, present, and future—summarizing where liquid biopsy is most actionable today, why performance varies across contexts, and ...
Liu J, Zeng D, Zhao K, Wang Y, Hu H, Deng F, Wang Y, Sun L, Fu L.   +8 more
europepmc   +2 more sources

Liquid Biopsy: Detection of Circulating Tumor Cells in Esophageal Squamous Cell Carcinoma

, 2020
Circulating tumor cells (CTC) harvested in the blood of patients with esophageal squamous cell carcinoma (ESCC) are associated with certain clinical pathological parameters as well as patients’ prognosis and response to chemoradiation.
Lam, AK, Hamid, FB, Faysal Bin Hamid, Vinod Gopalan, Gopalan, V, Alfred K. Lam   +5 more
core   +1 more source

CTC-5: A novel digital pathology approach to characterise circulating tumour cell biodiversity

, 2023
Metastatic progression and tumor evolution complicates the clinical management of cancer patients. Circulating tumor cell (CTC) characterization is a growing discipline that aims to elucidate tumor metastasis and evolution processes.
O'Riain, C., Brooks, R.D., S A O'Toole (14607052), Ffrench, B., Kashdan, E., C D Spillane (14607031), Scholz, D., Leonie Young (7895759), Varešlija, D., Brooks, D.A., Gallagher, M., W Kamran (14607050), O'Toole, S.A., Young, L., Y Huang (5107763), Charmsaz, S., AbuSaadeh, F., C Martin (7772414), J J O'Leary (14607053), Gleeson, N., M Gallagher (13424349), C O'Brien (7805933), Selemidis, S., Sinead Cocchiglia (8484729), Cocchiglia, S., Flavin, R., S Selemidis (9630146), Huang, Y., O'Leary, J.J., B Ffrench (14580358), N Gleeson (14320311), O'Brien, C., C O'Riain (14320245), Kamran, W., E Kashdan (14607028), Damir Vareslija (7895321), Martin, C., D A Brooks (13351527), R Flavin (11499493), R D Brooks (14607045), Spillane, C.D., Sara Charmsaz (7896116), F AbuSaadeh (14607047), D Scholz (14607043), C. Martin, Spillane, C D, D. Scholz, J.J. O'Leary, Scholz, D, Martin, C, W. Kamran, Flavin, R, F. AbuSaadeh, Ffrench, B, Brooks, R D, Selemidis, S, D.A. Brooks, Kamran, W, O'Leary, J J, Gallagher, M, B. Ffrench, R. Flavin, N. Gleeson, O'Riain, C, S. Cocchiglia, Varešlija, D, S. Charmsaz, Cocchiglia, S, Y. Huang, C. O'Brien, AbuSaadeh, F, Charmsaz, S, S. Selemidis, C.D. Spillane, Brooks, D A, L. Young, Gleeson, N, Young, L, M. Gallagher, Kashdan, E, D. Varešlija, S.A. O'Toole, Huang, Y, R.D. Brooks, O'Toole, S A, E. Kashdan, C. O'Riain, O'Brien, C   +87 more
core   +1 more source

StarDist Image Segmentation Improves Circulating Tumor Cell Detection [PDF]

, 2022
SIMPLE SUMMARY: Automated enumeration of circulating tumor cells (CTC) from immunofluorescence images starts with a selection of areas containing potential CTC.
Michiel Stevens, Leon W. M. M. Terstappen, Christiane Driemel, Nanou, Afroditi, Driemel, Christiane, Terstappen, Leon W. M. M., Stoecklein, Nikolas H., Coumans, Frank A. W., Afroditi Nanou, Stevens, Michiel, Frank A. W. Coumans, Nikolas H. Stoecklein   +11 more
core   +1 more source

Cultured circulating tumor cells and their derived xenografts for personalized oncology

Asian Journal of Urology, 2016
Recent cancer research has demonstrated the existence of circulating tumor cells (CTCs) in cancer patient's blood. Once identified, CTC biomarkers will be invaluable tools for clinical diagnosis, prognosis and treatment.
Ruoxiang Wang, Gina C.Y. Chu, Stefan Mrdenovic, Alagappan A. Annamalai, Andrew E. Hendifar, Nicholas N. Nissen, James S. Tomlinson, Michael Lewis, Nallasivam Palanisamy, Hsian-Rong Tseng, Edwin M. Posadas, Michael R. Freeman, Stephen J. Pandol, Haiyen E. Zhau, Leland W.K. Chung   +14 more
doaj   +1 more source

Blood indices and circulating tumor cells for predicting metastasis of hepatocellular carcinoma after liver transplantation

Journal of Laboratory Medicine, 2022
Liver transplantation (LT) can benefit the long-term survival of hepatocellular carcinoma (HCC) patients. We hypothesized that circulating tumor cell (CTC) levels and subtypes are intimately associated with metastasis status of HCC patients.
Zhuang Li, Liu Xiang-Yan, Zhu Heng-Kai, Wang Zhuo-Yi, Zhang Wu, Jiang Guo-Ping, Zheng Shu-Sen   +6 more
doaj   +1 more source

Elucidating PI3K/AKT/PTEN Pathway Alterations at Single-Cell Level in CTCs From HR+/HER2- Metastatic Breast Cancer. [PDF]

Cancer Sci
Single CTC analysis revealed extensive inter‐ and intra‐patient heterogeneity of PI3K/AKT/PTEN pathway alterations in HR+/HER2− metastatic breast cancer, capturing both SNVs and CNAs, including PTEN loss‐of‐function events. Longitudinal CTC profiling also uncovered dynamic clonal evolution, highlighting its potential to complement tissue and ctDNA ...
Rossi T, Palleschi M, Gianni C, Merloni F, Virga A, Bandini S, Angeli D, Tebaldi M, Maltoni R, Ulivi P, Musolino A.   +10 more
europepmc   +2 more sources

Liquid Biopsy in Clinical Management of Breast, Lung, and Colorectal Cancer

Frontiers in Medicine, 2018
Examination of tumor molecular characteristics by liquid biopsy is likely to greatly influence personalized cancer patient management. Analysis of circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and tumor-derived exosomes, all collectively
Ivana Bratić Hench, Jürgen Hench, Markus Tolnay   +2 more
doaj   +1 more source

Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells

Nature Communications, 2017
The current FDA-approved whole blood stabilization method for circulating tumor cell (CTC) isolation suffers from RNA degradation. Here the authors combine hypothermic preservation and antiplatelet strategies to stabilize whole blood up to 72 h without ...
Keith H. K. Wong, Shannon N. Tessier, David T. Miyamoto, Kathleen L. Miller, Lauren D. Bookstaver, Thomas R. Carey, Cleo J. Stannard, Vishal Thapar, Eric C. Tai, Kevin D. Vo, Erin S. Emmons, Haley M. Pleskow, Rebecca D. Sandlin, Lecia V. Sequist, David T. Ting, Daniel A. Haber, Shyamala Maheswaran, Shannon L. Stott, Mehmet Toner   +18 more
doaj   +1 more source

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry

Scientific Reports, 2017
Circulating tumor cell clusters (CTC clusters) are potent initiators of metastasis and potentially useful clinical markers for patients with cancer. Although there are numerous devices developed to isolate individual circulating tumor cells from blood ...
Sam H. Au, Jon Edd, Amy E. Stoddard, Keith H. K. Wong, Fabio Fachin, Shyamala Maheswaran, Daniel A. Haber, Shannon L. Stott, Ravi Kapur, Mehmet Toner   +9 more
doaj   +1 more source