Results 41 to 50 of about 6,225,689 (197)

CTC status in respect to clinical status of the patients.

, 2013
CTC – circulating tumor cell.
Volkmar Müller (86722), Julia Spötter (460208), Klaus Pantel (86726), Simon A. Joosse (194244), Anna Babayan (460207), Juliane Hannemann (23632)   +5 more
core   +1 more source

Cytopathological Study of the Circulating Tumor Cells filtered from the Cancer Patients’ Blood using Hydrogel-based Cell Block Formation

Scientific Reports, 2018
Circulating tumor cells have emerged as biomarkers for estimating the tumor burden and metastatic potential of cancer patients. However, to date, most of studies and applications of circulating tumor cells have been conducted and applied to epithelial ...
Yoon-Tae Kang, Young Jun Kim, Tae Hee Lee, Young-Ho Cho, Hee Jin Chang, Hyun-Moo Lee   +5 more
doaj   +1 more source

The functional and clinical roles of liquid biopsy in patient-derived models

Journal of Hematology & Oncology, 2023
The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters in blood, as well as the detection of, cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) and extracellular vesicles (EVs) in the patient's body fluid.
Ziqing Zhu, Erya Hu, Hong Shen, Jun Tan, Shan Zeng   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Size-Based and Non-Affinity Based Microfluidic Devices for Circulating Tumor Cell Enrichment and Characterization

, 2016
Circulating Tumor Cells (CTCs) are tumor cells found in cancer patients’ peripheral blood. Enumeration of CTCs can provide prognosis information for cancer management (Cristofanilli et al., N Engl J Med 351(8):781–791, 2004; Cohen et al., J Clin Oncol 26(
Richard J. Cote, Cote, Richard J, Zheng Ao, Datar, Ram H, Kamran Moradi, Moradi, Kamran, Ram H. Datar, Ao, Zheng   +7 more
core   +1 more source

Detection of androgen receptor mutations in circulating tumor cells in castration-resistant prostate cancer [PDF]

, 2010
receptor) gene have been identified in tissue samples from patients with advanced prostate cancer and rep-resent a possible mechanism underlying the develop-ment of castration-resistant prostate cancer (CRPC).
John F. Palma, Yixin Wang, Yuqiu Jiang, Mitchell E Gross, David B. Agus, John F Palma, David B Agus, Mitchell E. Gross   +7 more
core   +1 more source

Microfilter-Based Capture and Release of Viable Circulating Tumor Cells

, 2017
Microfilters with slot-pore geometry can be used for size-based capture of circulating tumor cells (CTC) from the blood of cancer patients. The slot pore geometry reduces the shear stress that the cells would typically experience during filtration ...
Siddarth Rawal, Zheng Ao, Agarwal, Ashutosh, Datar, Ram H, Ashutosh Agarwal, Ram H. Datar, Rawal, Siddarth, Ao, Zheng   +7 more
core   +1 more source

EpCAMlow circulating tumor cells: Gold in the waste [PDF]

, 2019
The CellSearch® system which is still considered the gold standard for the enumeration of circulating tumor cells (CTC) utilizes antibodies against the epithelial cell adhesion molecule (EpCAM) for CTC enrichment.
Raimondi C., Gradilone A., Loreni F., Nicolazzo C., Gazzaniga P.   +4 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source