Results 61 to 70 of about 6,225,689 (197)

The Mechanical Fingerprint of Circulating Tumor Cells (CTCs) in Breast Cancer Patients

, 2021
Circulating tumor cells (CTCs) are a potential predictive surrogate marker for disease monitoring. Due to the sparse knowledge about their phenotype and its changes during cancer progression and treatment response, CTC isolation remains challenging. Here
Bahriye Aktas, Dimitrij Tschodu, Ivonne Nel, Erik W. Morawetz, Josef A. Käs   +4 more
core   +1 more source

A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation

iScience
Summary: Circulating tumor cell (CTC) clusters are often detected in blood samples of patients with high-grade tumor and are associated with tumor metastasis and poor prognosis.
Yukinori Ikeda, Makoto Kondo, Jun-ichi Suehiro, Hiroko Oshima, Sau Yee Kok, Kazuki Takahashi, Joris Pauty, Dong Wang, Hiroyuki Sakurai, Tetsuro Watabe, Masanobu Oshima, Yukiko T. Matsunaga   +11 more
doaj   +1 more source

Rapid‐Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing

Advanced Science, EarlyView.
The SPG‐MpECis electrochemical POCT platform developed in this study enables direct detection of biomarkers in complex biological samples such as serum and fingerstick blood, demonstrating high concordance with results from clinical reference methods and holding broad potential for at‐home testing applications.
Menghan Li, Kai Su, Ruiwei Hu, Ke Gao, Yuanjie Liu, Lu Zhang, Ningke Fan, Yirong Chen, Wei Cheng, Shijia Ding, Haiping Wu   +10 more
wiley   +1 more source

CTC-Race: Single-Cell Motility Assay of Circulating Tumor Cells from Metastatic Lung Cancer Patients

Distinctive subpopulations of circulating tumor cells (CTCs) with increased motility are considered to possess enhanced tumor-initiating potential and contribute to metastasis.
Christen N. Cooper Pope (18135747), Petros G. Nikolinakos (15043736), Wujun Zhao (18135741), Glenda Hicks (18135750), Leidong Mao (1332129), Mary Egan (5799293), Yang Liu (4829), Jamie Hodgson (18135744)   +7 more
core   +1 more source

Additional file 9: of Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer

, 2018
Table S7. Clinical features of patients with single circulating tumor cell and circulating tumor cell clusters. The table shows clinical features of patients in whom only single circulating tumor cells (CTC single cell) or also clustered circulating ...
Viola Heinzelmann-Schwarz (390410), Barbara Szczerba (5997695), Walter Weber (5997716), Christoph Rochlitz (190083), Ramona Scherrer (5997704), Christian Kurzeder (5997713), Marcus Vetter (3422660), Alfred Zippelius (805066), Ilona Krol (5997701), Julia Landin (5997692), Cinzia Donato (5997698), Alexandra Malinovska (5997710), Sofia Gkountela (191896), Francesc Castro-Giner (5659600), Catharina Balmelli (5997707), Nicola Aceto (5997719)   +15 more
core   +1 more source

Cell Lines of Circulating Tumor Cells: What Is Known and What Needs to Be Resolved

, 2022
The importance of circulating tumor cells (CTC) is well recognized. However, the biological characteristics of CTC in the bloodstream have not yet been examined in detail, due to the limited number of CTC cell lines currently available.
Myomoto, Akira, Takuro Sunada, Okano, Kiyoshi, Yutaka Shimada, Kazuharu Shimizu, Shimizu, Kazuharu, Akira Myomoto, Akamatsu, Shusuke, Tetsuo Sudo, Sudo, Tetsuo, Sunada, Takuro, Kiyoshi Okano, Shimada, Yutaka, Shusuke Akamatsu   +13 more
core   +1 more source

Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology

Cells, 2019
Circulating tumor cells (CTCs) and circulating tumor microemboli (CTM) have been shown to correlate negatively with patient survival. Actual CTC counts before and after treatment can be used to aid in the prognosis of patient outcomes.
Patrick C. Bailey, Stuart S. Martin
doaj   +1 more source

Defining the dimensions of circulating tumor cells in a large series of breast, prostate, colon, and bladder cancer patients

Molecular Oncology, 2021
Circulating tumor cells (CTCs) in the blood of cancer patients are of high clinical relevance. Since detection and isolation of CTCs often rely on cell dimensions, knowledge of their size is key.
Pauline A. J. Mendelaar, Jaco Kraan, Mai Van, Leonie L. Zeune, Leon W. M. M. Terstappen, Esther Oomen‐de Hoop, John W. M. Martens, Stefan Sleijfer   +7 more
doaj   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Circulating Tumor Cell Isolation and Diagnostics: Toward Routine Clinical Use

, 2011
From February 7–11, 2011, the multidisciplinary Lorentz Workshop Circulating Tumor Cell (CTC) Isolation and Diagnostics: Toward Routine Clinical Use was held in Leiden (The Netherlands) to discuss progress and define challenges and potential solutions ...
Pantel, K., Stolpe, van de, A., Stefan Sleijfer, Sleijfer, Stefan, Stolpe, A, Pantel, K, Leon W. Terstappen, Terstappen, L.W., Jaap M.J. den Toonder, van der Stolpe, A., den Toonder, JMJ, Terstappen, LW, Toonder, den, J.M.J.; id_orcid, den Toonder, J.M.J., Anja van de Stolpe, Sleijfer, S., Klaus Pantel, Terstappen, Leonardus Wendelinus Mathias Marie   +17 more
core   +1 more source