Results 91 to 100 of about 2,021,965 (393)

Circulating Tumor Cells Undergoing EMT Provide a Metric for Diagnosis and Prognosis of Patients with Hepatocellular Carcinoma.

Cancer Research, 2018
To clarify the significance of circulating tumor cells (CTC) undergoing epithelial-mesenchymal transition (EMT) in patients with hepatocellular carcinoma (HCC), we used an advanced CanPatrol CTC-enrichment technique and in situ hybridization to enrich ...
Lu-Nan Qi, B. Xiang, Fei-Xiang Wu, J. Ye, J. Zhong, Yan-Yan Wang, Yuan-yuan Chen, Zushun Chen, Liang Ma, Jie Chen, W. Gong, Ze-Guang Han, Yan Lu, Jin-Jie Shang, Lequn Li   +14 more
semanticscholar   +1 more source

Circulating Tumor Cells and Melanoma Progression [PDF]

Journal of Investigative Dermatology, 2010
Circulating tumor cells (CTCs) are cancer cells shed from either a primary tumor or its metastases that circulate in the peripheral blood. CTCs are potential seeds for metastases, and analyses of CTCs may allow earlier detection of metastasis-capable malignancy, monitoring for tumor recurrence, and accurate prognostication. Studies on CTCs have focused
Jiang F. Zhong, Xiaowei Xu
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology. [PDF]

, 2017
There has been increased interest in utilizing non-invasive "liquid biopsies" to identify biomarkers for cancer prognosis and monitoring, and to isolate genetic material that can predict response to targeted therapies. Circulating tumor cells (CTCs) have
Che, James, Di Carlo, Dino, Jeffrey, Stefanie S, Kulkarni, Rajan P, Lemaire, Clementine A, Liu, Haiyan E, Matsumoto, Melissa, Pao, Edward, Renier, Corinne, Rettig, Matthew, Sollier-Christen, Elodie, Srivinas, Sandy, Triboulet, Melanie   +12 more
core   +1 more source

Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset

Cancers, 2019
The release of circulating tumor cells (CTCs) into vasculature is an early event in the metastatic process. The analysis of CTCs in patients has recently received widespread attention because of its clinical implications, particularly for precision ...
Chiara Agnoletto, Fabio Corrà, Linda Minotti, F. Baldassari, Francesca Crudele, W. Cook, Gianpiero di Leva, A. d’Adamo, P. Gasparini, S. Volinia   +9 more
semanticscholar   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Isolation of circulating tumor cells in non-small-cell-lung-cancer patients using a multi-flow microfluidic channel

Microsystems & Nanoengineering, 2019
Circulating tumor cells (CTCs) carry a wealth of information on primary and metastatic tumors critical for precise cancer detection, monitoring, and treatment.
Jian Zhou, A. Kulasinghe, Amanda Bogseth, K. O'Byrne, C. Punyadeera, I. Papautsky   +5 more
semanticscholar   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Comprehensive liquid biopsy analysis for monitoring NSCLC patients under second-line osimertinib treatment

Frontiers in Oncology
BackgroundThe heterogeneous and complex genetic landscape of NSCLC impacts the clinical outcomes of patients who will eventually develop resistance to osimertinib.
Aliki Ntzifa, Theodoros Marras, Galatea Kallergi, Athanasios Kotsakis, Vasilis Georgoulias, Evi Lianidou   +5 more
doaj   +1 more source

Distinct mutation profiles between primary bladder cancer and circulating tumor cells warrant the use of circulating tumors cells as cellular resource for mutation follow-up

BMC Cancer, 2020
Background While circulating tumor cells may serve as minimally invasive cancer markers for bladder cancers, the relationship between primary bladder cancers and circulating tumor cells in terms of somatic mutations is largely unknown.
Tae-Min Kim, Jin-seon Yoo, Hyong Woo Moon, Kyung Jae Hur, Jin Bong Choi, Sung-Hoo Hong, Ji Youl Lee, U-Syn Ha   +7 more
doaj   +1 more source