Results 71 to 80 of about 322,217 (303)

Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma

Analytical Cellular Pathology, 2018
Hemangiopericytoma (HPT) is a rare mesenchymal tumor of fibroblastic type and for its rarity is poorly studied. The most common sites of metastatic disease in patients with intracranial HPT are the bone, liver, and lung, suggestive for an hematogenous ...
Chiara Nicolazzo, Luciano Colangelo, Alessandro Corsi, Guido Carpino, Angela Gradilone, Chiara Sonato, Cristina Raimondi, Eugenio Gaudio, Paola Gazzaniga, Walter Gianni   +9 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Circulating Tumor Cells in Right- and Left-Sided Colorectal Cancer [PDF]

, 2019
Molecular alterations are not randomly distributed in colorectal cancer (CRC), but rather clustered on the basis of primary tumor location underlying the importance of colorectal cancer sidedness.
Ann Zeuner, Silverio Tomao, Valentina Magri, Alessandra Emiliani, Angela Gradilone, Chiara Nicolazzo, Patrizia Seminara, Flavia Loreni, Francesca Belardinilli, Cristina Raimondi, Federica Francescangeli, Paola Gazzaniga   +11 more
core   +1 more source

NALCN Promoter Methylation as a Biomarker for Metastatic Risk in a Cohort of Non-Small Cell Lung Cancer Patients

Biomolecules
Liquid biopsy enables real-time monitoring of tumor development and response to therapy through the analysis of CTCs and ctDNA. NALCN is a sodium leak channel that is frequently involved in tumor evolution and immunity and acts as a tumor suppressor ...
Eleni Thanou, Dora Lontra, Ioanna Balgouranidou, Eleni Efthimiadou, Alexandra Delipetrou, Emilia Tsaroucha, Maria Theodosiou, Vassilis Georgoulias, Athanasios Kotsakis, Evi Lianidou, Athina Markou   +10 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Circulating tumor cells in oncology

Сибирский онкологический журнал, 2022
Purpose of the study: to identify general patterns in the presence of detectable amounts of circulating tumor cells (CTCs) negatively correlated with the overall survival of patients and their ability to form metastases in distant tissues and organs, as ...
D. I. Vodolazhsky, T. L. Nekhaeva, I. A. Baldueva   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Specific antigen of tumor cell transformed by DNA extracted from SV-40 virus [PDF]

, 1967
In the immunofluorescent study it has been revealed that rabbit sera immunized with transformed cells induced by SV-40 DNA, produce circulating antibody capable of re:lcting with intranuclear antigens synthesized by SV-40 complyte virus transforming ...
Okada, Shigeru, Grace, James T., Hayashi, Kenj, Kimoto, Tetsuo, Sogabe, Koichi, Shigehisa, Morio   +5 more
core   +1 more source

The Mechanical Fingerprint of Circulating Tumor Cells (CTCs) in Breast Cancer Patients [PDF]

, 2021
Circulating tumor cells (CTCs) are a potential predictive surrogate marker for disease monitoring. Due to the sparse knowledge about their phenotype and its changes during cancer progression and treatment response, CTC isolation remains challenging. Here
Bahriye Aktas, Dimitrij Tschodu, Ivonne Nel, Erik W. Morawetz, Josef A. Käs   +4 more
core   +1 more source

Clinical Significance of Circulating Tumor Cells

Biomarkers in Medicine, 2007
The first discovery of circulating tumor cells (CTCs) is attributed to Ashworth in 1869, who noted the presence of cancer cells in the blood. Generally it has been difficult to measure CTCs accurately because they exist in a low frequency and separation from other cell types (red blood cells, normal epithelial cells and leukocytes) has limited ...
Apostolopoulos, Christos, Giamas, Georgios, Stebbing, Justin   +2 more
openaire   +3 more sources