Results 91 to 100 of about 490,680 (293)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cell lines from circulating tumor cells

Oncoscience, 2015
Circulating tumor cells (CTCs) in the blood of cancer patients have received increasing attention as new diagnostic tool enabling “liquid biopsies” [1]. The perspective to avoid invasive tissue biopsies in the future and obtain similar or even more information by a “simple” blood test has enormous implications in cancer diagnostics [2].
Klaus, Pantel, Catherine, Alix-Panabières   +1 more
openaire   +2 more sources

Application of circulating tumor cells scope technique on circulating tumor cell research [PDF]

Molecular and Cellular Therapies, 2014
Circulating tumor cells (CTCs) are becoming promising biomarkers in several cancers, such as colon, prostate, and breast carcinomas. Independent research groups have reported a correlation between CTC numbers and patient prognosis. Even more, the development of personalized medicine gives physicians impetus to utilize the advancement of molecular ...
Yang, Dawei, Wang, Lijie, Tian, Xiaochen
openaire   +2 more sources

Cancer cells exploit an orphan RNA to drive metastatic progression. [PDF]

, 2018
Here we performed a systematic search to identify breast-cancer-specific small noncoding RNAs, which we have collectively termed orphan noncoding RNAs (oncRNAs).
A Fabregat, A Helwak, AA Margolin, AJ Minn, Alicia Y. Zhou, AM Ainsztein, Andrei Goga, AR Kodahl, AR Quinlan, B Kim, B Langmead, Bruce Culbertson, C Roth, CI Wu, CJ David, D Huo, D Ray, DK Simanshu, DN Cooper, EL Nostrand Van, H Goodarzi, H Goodarzi, H Goodarzi, H Goodarzi, Hani Goodarzi, JM Loo, Johnny X. Yu, K Cuk, L Fish, Lisa Fish, LY Chen, M Rehmsmeier, MI Love, MJ Moore, NN Hooten, O Elemento, PD Bos, R Bhargava, R Ren, RK Lin, RO Bak, S Kishore, S Vanharanta, SF Tavazoie, Steven Zhang, T Fiskaa, W Zhou, X Wu, YCT Yang, YS DeRose   +49 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circulating Tumor Cells and Fibronectin 1 in the Prognosis of Nasopharyngeal Carcinoma

Technology in Cancer Research & Treatment, 2020
Objective: Nasopharyngeal carcinoma is highly endemic in Southeast China. Circulating tumor cell is an important biomarker in the prognosis of variety kinds of cancers. Overexpression of fibronectin 1 was observed in variety kinds of malignancies and may
Ying Yu BM, Zhi-Xiu Lin BM, Hai-Wen Li MM, Hai-Qing Luo MD, Dong-Hong Yang MM, He-Chao Zhou MM, Dan-Xian Jiang MD, De-Chao Zhan MM, Liu Yang MM, Xiao-Ye Liang MM, Zhong-Hua Yu MM, Zi-Hong Chen BM   +11 more
doaj   +1 more source

Pathologic evaluation of tumor-associated macrophage density and vessel inflammation in invasive breast carcinomas [PDF]

, 2017
Tumor-associated macrophages (TAMs) are major constituents of the tumor microenvironment in solid tumors and have been implicated as mediators of tumor progression, invasion and metastasis.
Adhikari, Smita, Chervoneva, Inna, Hasan, Nafis, Leslie, Macall, Morita, Yoshihiro, Rui, Hallgeir, Tanaka, Takemi, Zhang, Roy   +7 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Direct comparison of an ultrasensitive real-time PCR assay with droplet digital PCR for the detection of PIK3CA hotspot mutations in primary tumors, plasma cell-free DNA and paired CTC-derived gDNAs

Frontiers in Oncology
IntroductionDetection of PIK3CA mutations in primary tumors and liquid biopsy samples is of increasing importance for treatment decisions and therapy resistance in many types of cancer. The aim of the present study was to directly compare the efficacy of
Stavroula Smilkou, Loukas Kaklamanis, Ioanna Balgouranidou, Helena Linardou, Alkistis Maria Papatheodoridi, Flora Zagouri, Evangelia Razis, Stylianos Kakolyris, Amanda Psyrri, Christos Papadimitriou, Athina Markou, Evi Lianidou   +11 more
doaj   +1 more source

Detection of FAM172A expressed in circulating tumor cells is a feasible method to predict high-risk subgroups of colorectal cancer

Tumor Biology, 2017
Previous studies used to enumerate circulating tumor cells to predict prognosis and therapeutic effect of colorectal cancer. However, increasing studies have shown that only circulating tumor cells enumeration was not enough to reflect the heterogeneous ...
Chun-Hui Cui, Ri-hong Chen, Duan-Yang Zhai, Lang Xie, Jia Qi, Jin-Long Yu   +5 more
doaj   +1 more source