A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative [PDF]
, 2016 Recent improvements in next-generation sequencing (NGS) technology have enabled detection of biomarkers in cell-free DNA in blood and may ultimately replace invasive tissue biopsies.
Aberra, Metasebia +15 more
core +2 more sources
Nucleosomes in serum as a marker for cell death [PDF]
, 2001 The concentration of nucleosomes is elevated in blood of patients with diseases which are associated with enhanced cell death. In order to detect these circulating nucleosomes, we used the Cell Death Detection-ELISA(Plus) (CDDE) from Roche Diagnostics ...
Anker P +15 more
core +1 more source
Clinical and Experimental Obstetrics & Gynecology, 2023 This paper encourages understanding a non-invasive technology—the “Liquid biopsy”, including circulating tumor cells (CTCs) and circulating tumor DNA (ct DNA) technology, that can help diagnose early cancers, cancer relapse, and resistance to ...
Felix Wong +2 more
doaj +1 more source
Detection of activating estrogen receptor gene (ESR1) mutations in single circulating tumor cells [PDF]
, 2017 Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our purpose was to demonstrate feasibility to detect and monitor estrogen receptor 1 (ESR1) gene mutations at the single circulating tumor cell (CTC) level in ...
Austin, Laura +9 more
core +3 more sources
Visceral Adipose Tissue Inflammatory Factors (TNF-Alpha, SOCS3) in Gestational Diabetes (GDM): Epigenetics as a Clue in GDM Pathophysiology [PDF]
, 2020 Gestational diabetes (GDM) is among the most challenging diseases in westernized countries, affecting mother and child, immediately and in later life. Obesity is a major risk factor for GDM.
Henrich, Wolfgang +6 more
core +1 more source
Total Number of Alterations in Liquid Biopsies Is an Independent Predictor of Survival in Patients With Advanced Cancers. [PDF]
, 2020 PurposeStudies have demonstrated an association between quantity of circulating tumor DNA (ctDNA) and poorer survival. We investigated the relationship between percent ctDNA (%ctDNA), total number of ctDNA alterations, and overall survival (OS) in liquid
Goodman, Aaron +4 more
core
Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology. [PDF]
, 2017 There has been increased interest in utilizing non-invasive "liquid biopsies" to identify biomarkers for cancer prognosis and monitoring, and to isolate genetic material that can predict response to targeted therapies. Circulating tumor cells (CTCs) have
Che, James +12 more
core +1 more source
Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
Nature Communications, 2021 Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is ...
Guanhua Zhu +19 more
doaj +1 more source
Detection of TMPRSS2 : ERG fusion gene in circulating prostate cancer cells [PDF]
, 2008 Creative Commons Attribution-NonCommercial-Share Alike 3.0 license (CC BY-NC SA)Aim: To investigate the existence of TMPRSS2:ERG fusion gene in circulating tumor cells (CTC) from prostate cancer patients and its potential in monitoring tumor metastasis ...
Bryan D. Young +16 more
core +1 more source
Circulating cell-free DNA and circulating tumor cells, the “liquid biopsies” in ovarian cancer
Journal of Ovarian Research, 2017 Limited understanding of ovarian cancer (OC) genome portrait has hindered the therapeutic advances. The serial monitoring of tumor genotypes is becoming increasingly attainable with circulating cell-free DNA (cf-DNA) and circulating tumor cells (CTCs ...
Xianliang Cheng +3 more
doaj +1 more source