Results 41 to 50 of about 651,238 (350)

Cell Death and Liver Disease

Gut and Liver, 2020
Cell death is now reclassified into several types based on the mechanisms and morphologic phenotype. Understanding of such classifications offers insights into the pathogenesis of liver disease, as well as diagnostic or therapeutic implications ...
Satoka Aizawa, Gurmehr Brar, Hidekazu Tsukamoto   +2 more
doaj   +1 more source

Intrarenal Resistance Index as a Prognostic Parameter in Patients with Liver Cirrhosis Compared with Other Hepatic Scoring Systems [PDF]

, 2012
Background and Aims: Patients with advanced liver cirrhosis who develop renal dysfunction have a poor prognosis. Elevated intrarenal resistance indices (RIs) due to renal vascular constriction have been described before in cirrhotic patients.
Bardi A, C. Kaiser, Colli A, Conn HO, European, Ginès A, Götzberger M, Hanley JA, Hanley JA, J. Singer, Kastelan S, M. Götzberger, Sacerdoti A, V. Gülberg, Wang Y   +14 more
core   +1 more source

Effect of sarcopenia on survival in patients with cirrhosis: A systematic review and meta-analysis.

Journal of Hepatology, 2021
BACKGROUND & AIMS The association between sarcopenia and prognosis in patients with cirrhosis remains to be determined. In this study, we aimed to quantify the association between sarcopenia and the risk of mortality in patients with cirrhosis, by sex ...
Xinxing Tantai, Yi Liu, Y. Yeo, M. Praktiknjo, E. Mauro, Y. Hamaguchi, C. Engelmann, Peng Zhang, J. Jeong, J. V. van Vugt, Huijuan Xiao, H. Deng, X. Gao, Q. Ye, Jiayuan Zhang, Longbao Yang, Yaqin Cai, Yixin Liu, Na Liu, Zongfang Li, T. Han, T. Kaido, J. Sohn, C. Strassburg, T. Berg, J. Trebicka, Yao-Chun Hsu, J. Ijzermans, Jinhai Wang, G. Su, F. Ji, M. Nguyen   +31 more
semanticscholar   +1 more source

Hemodynamic Evaluation of Nonselective \u3b2-Blockers in Patients with Cirrhosis and Refractory Ascites [PDF]

, 2018
BACKGROUND:Nonselective \u3b2-blockers (NSBB) have been associated with increased incidence of paracentesis-induced circulatory dysfunction (PICD) and reduced survival in patients with cirrhosis and refractory ascites.
Angeli, Paolo, Burra, Patrizia, Casiglia, Edoardo, Faggian, Diego, Fasolato, Silvano, Ferrarese, Alberto, Germani, Giacomo, Russo, Francesco Paolo, Senzolo, Marco, Tikhonoff, Valerie, Zanetto, Alberto   +10 more
core   +2 more sources

Rising plasma nociceptin level during development of HCC: A case report [PDF]

, 2004
AIM: Although liver cirrhosis is a predisposing factor for hepatocellular carcinoma (HCC), relatively few reports are available on HCC in primary biliary cirrhosis.
Folhoffer, Anikó, Halász, Judit, Hantos, Mónika Beatrix, Horváth, Andrea, Illyés, György, Lakatos, Péter László, Schaff, Zsuzsa, Szalay, Ferenc, Tekes, Kornélia   +8 more
core   +1 more source

Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions

World Journal of Gastroenterology, 2022
Cirrhosis causes a heavy global burden. In this review, we summarized up-to-date epidemiological features of cirrhosis and its complications. Recent epidemiological studies reported an increase in the prevalence of cirrhosis in 2017 compared to in 1990 ...
Yuanbin Liu, Ming-Kai Chen
semanticscholar   +1 more source

Liver transplantation in primary biliary cirrhosis: Risk assessment and 11-year follow-up [PDF]

, 2000
Background/Aims: Liver transplantation (LTx) is the only established treatment in patients with end-stage primary biliary cirrhosis (PBC). Although short-term survival after LTx in this group of patients is usually good, few data exist on the long-term ...
Beuers, Ulrich, Gerbes, Alexander L., Haller, Matthias, Krämling, Hans-Jörg, Pape, Gerd R., Paumgartner, Gustav, Rau, Horst, Rust, Christian, Schildberg, Friedrich Wilhelm   +8 more
core   +2 more sources

Carvedilol reduces the risk of decompensation and mortality in patients with compensated cirrhosis in a competing-risk meta-analysis.

Journal of Hepatology, 2022
Whether non-selective β-blockers can prevent decompensation of cirrhosis needs clarification. Carvedilol might be particularly effective since its intrinsic vasodilatory activity may ameliorate hepatic vascular resistance, a major mechanism of portal ...
C. Villanueva, F. Torres, S. Sarin, H. Shah, D. Tripathi, A. Brujats, S. Rodrigues, A. Bhardwaj, Zahid Azam, P. Hayes, A. Jindal, S. Abid, E. Alvarado, J. Bosch, A. Albillos, J. Genescà, J. García-Pagán, J. Calleja, C. Aracil, R. Bañares, R. Morillas, M. Poca, Beatriz Peñas, S. Augustin, J. Abraldes, Javeria Rauf, S. Hamid, W. Jafri, A. Khalid, F. Ismail, O. Parkash, Amna Subhan, S. M. Munir, J. Ferguson, N. Kochar, J. Leithead, G. Therapondos, N. Mcavoy, A. Stanley, E. Forrest, W. Hislop, P. Mills, C. Kedarisetty, C. Vashishtha, A. Bhadoria, G. Kumar, A. Choudhary, S. Shasthry, R. Maiwall, M. Kumar, V. Bhatia   +50 more
semanticscholar   +1 more source

Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis

Nature Communications, 2023
Hepatocellular carcinoma (HCC) is the 3rd most deadly malignancy. Activated hepatic stellate cells (aHSC) give rise to cancer-associated fibroblasts in HCC and are considered a potential therapeutic target.
Sonal Sinha, Satoka Aizawa, Yasuhiro Nakano, Alexander Rialdi, Hye Yeon Choi, Rajan Shrestha, Stephanie Q. Pan, Yibu Chen, Meng Li, Audrey Kapelanski-Lamoureux, Gregory Yochum, Linda Sher, Satdarshan Paul Monga, Anthoula Lazaris, Keigo Machida, Michael Karin, Ernesto Guccione, Hidekazu Tsukamoto   +17 more
doaj   +1 more source

Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease [PDF]

, 2013
Chronic hepatitis C virus infection (C-HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C-HC have thus far been based solely on telomere length as ...
Barclay, Stephen, McGuinness, Dagmara, McLauchlan, John, Mills, Peter R., Patel, Arvind H., Robinson, Mark W., Shiels, Paul G., Swann, Rachael   +7 more
core   +2 more sources