Results 11 to 20 of about 6,727 (271)

Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution.

PLoS ONE, 2019
PURPOSE:To evaluate the presence and concentration of citicoline and its metabolites (choline, cytidine and uridine) in the vitreous body in human eyes after topical application of an ophthalmic solution of citicoline 2%, in vivo.
Carmela Carnevale, Gianluca Manni, Gloria Roberti, Alessandra Micera, Luca Bruno, Andrea Cacciamani, Romeo Altafini, Luciano Quaranta, Luca Agnifili, Lucia Tanga, Ivano Riva, Francesco Oddone   +11 more
doaj   +9 more sources

Dysregulation of choline metabolism and therapeutic potential of citicoline in Huntington's disease. [PDF]

Aging Cell
Huntington's disease (HD) is associated with dysregulated choline metabolism, but the underlying mechanisms remain unclear. This study investigated the expression of key enzymes in this pathway in R6/2 HD mice and human HD postmortem brain tissues.
Chang KH, Cheng ML, Tang HY, Lin CY, Chen CM.   +4 more
europepmc   +3 more sources

Citicoline Triggers Proteome Remodeling and Proteostatic Adaptation: Evidence from Shotgun Proteomics [PDF]

Pharmaceutics
Background/Objectives: Citicoline, also known as CDP-choline, is a nootropic agent currently used in the treatment of glaucoma and is undergoing evaluation as a first-line therapy in a multi-center, international, phase III, randomized clinical trial ...
Dario Cavaterra, Sara Giammaria, Irene Pandino, Gabriele Antonio Zingale, Valerio Delli Paoli, Rebecca Fiore, Manuele Michelessi, Gloria Roberti, Carmela Carnevale, Lucia Tanga, Daniela Cazzato, Elisa Peroni, Giuseppe Grasso, Gianluca Manni, Alessio Bocedi, Francesco Oddone, Massimiliano Coletta, Diego Sbardella, Grazia Raffaella Tundo   +18 more
doaj   +2 more sources

An environmental green factorial design/assisted spectrofluorimetric technique for quantitation of citicoline in pharmaceutical dosage form and wastewater. [PDF]

Sci Rep
A novel, sensitive, and straightforward spectrofluorimetric method was developed for the quantitative determination of citicoline in pharmaceutical formulations and wastewater.
El-Alamin MMA, Elkhalek OA, Azab MM.
europepmc   +2 more sources

Ameliorative effect of citicoline on cyclophosphamide-induced lung injury. [PDF]

Open Vet J
Background: Cyclophosphamide (CP) is known to cause pulmonary injury through free radical production and proinflammatory cytokines activation. Lung damage is associated with significant mortality, primarily due to the development of severe inflammation ...
Salah R, El-Sayed G, El-Sherbini ES, El-Adl M.   +3 more
europepmc   +2 more sources

Citicoline for the Management of Patients with Traumatic Brain Injury in the Acute Phase: A Systematic Review and Meta-Analysis [PDF]

Life, 2023
Background: Citicoline or CDP-choline is a neuroprotective/neurorestorative drug used in several countries for the treatment of traumatic brain injury (TBI).
Julio José Secades, Helmut Trimmel, Byron Salazar, José Antonio González   +3 more
doaj   +2 more sources

Effects of citicoline administration on synaptic proteins in rapid eye movement sleep-deprived rats [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Sleep has a pivotal role in learning-memory and sleep deprivation (SD) negatively affects synaptic functioning. Cytidine-5-diphosphocholine (Citicoline) has been known to improve learning and memory functions.
Ayşen Cakir, Busra Ocalan, Cansu Koc, Guldal Gulec Suyen, Mehmet Cansev, Nevzat Kahveci   +5 more
doaj   +3 more sources

The Combined Effect of Green Tea, Saffron, Resveratrol, and Citicoline against Neurodegeneration Induced by Oxidative Stress in an In Vitro Model of Cognitive Decline. [PDF]

Oxid Med Cell Longev
During ageing, the brain is vulnerable to a growing imbalance of the antioxidant defence system, resulting in increased oxidative stress. This condition may be mainly responsible for cognitive decline, resulting in synaptic transmission disruptions and ...
Mulè S, Ferrari S, Rosso G, Galla R, Battaglia S, Curti V, Molinari C, Uberti F.   +7 more
europepmc   +2 more sources

Long-Term Treatment with Citicoline Prevents Cognitive Decline and Predicts a Better Quality of Life after a First Ischemic Stroke [PDF]

, 2016
Stroke, as the leading cause of physical disability and cognitive impairment, has a very significant impact on patients' quality of life (QoL). The objective of this study is to know the effect of citicoline treatment in Qol and cognitive performance in ...
Alvárez Sabín, J., Jacas, Carlos, Maisterra Santos, Olga, Molina, Carlos, Quintana Luque, Manuel, Santamarina Pérez, Estevo   +5 more
core   +5 more sources

SCARLET (Supplemental Citicoline Administration to Reduce Lung injury Efficacy Trial): study protocol for a single-site, double-blinded, placebo-controlled, and randomized Phase 1/2 trial of i.v. citicoline (CDP-choline) in hospitalized SARS CoV-2-infected patients with hypoxemic acute respiratory failure

Trials
Background The SARS CoV-2 pandemic has resulted in more than 1.1 million deaths in the USA alone. Therapeutic options for critically ill patients with COVID-19 are limited.
Sonal Pannu, Matthew C. Exline, Joseph S. Bednash, Joshua A. Englert, Philip Diaz, Amy Bartlett, Guy Brock, Qing Wu, Ian C. Davis, Elliott D. Crouser   +9 more
doaj   +2 more sources