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Discovery of a second citric acid cycle complex [PDF]
Heliyon, 2023 Together, Nobel Prize honoured work, mathematics, physics and the laws of nature have drawn a concept of clockwise cycling carboxylic acids in Krebs’ Citric Acid Cycle. A Citric Acid Cycle complex is defined by specific substrate, product and regulation.
Dirk Roosterman, Graeme Stuart Cottrell
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Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle [PDF]
Nature Communications, 2018 The citric acid cycle (TCA) is a fundamental metabolic pathway to release stored energy in living organisms. Here, the authors report two linked cycles of reactions that each oxidize glyoxylate into CO2 and generate intermediates shared with the modern ...
Greg Springsteen +4 more
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Abiotic origin of the citric acid cycle intermediates. [PDF]
Proc Natl Acad Sci U S AThe molecular framework for protometabolism—chemical reactions in a prebiotic environment preceding modern metabolism—has remained unknown in evolutionary biology. Mono-, di-, and tricarboxylic acids that comprise contemporary metabolism, such as the Krebs cycle, are of particular prebiotic relevance and are theorized to predate life on Earth ...
McAnally M +6 more
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Hgt17-Adr1 Relationship in Candida albicans Citrate Utilization [PDF]
Journal of FungiThe fungal pathogen Candida albicans can infect diverse tissues, a reflection of its broad metabolic repertoire. The transcription factor Adr1 is required for utilization of several citric acid cycle intermediates that are found in tissue.
Amelia M. White, Aaron P. Mitchell
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Citric acid cycle and the origin of MARS. [PDF]
Trends Biochem Sci, 2013 The vertebrate multiaminoacyl tRNA synthetase complex (MARS) is an assemblage of nine aminoacyl tRNA synthetases (ARSs) and three non-synthetase scaffold proteins, aminoacyl tRNA synthetase complex-interacting multifunctional protein (AIMP)1, AIMP2, and AIMP3.
Eswarappa SM, Fox PL.
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Impaired Citric Acid Cycle in Nondiabetic Chronic Kidney Disease [PDF]
EBioMedicine, 2017 Zhanjun Jia
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Citric Acid in Endodontics: A Review [PDF]
Journal of Dental Materials and Techniques, 2021 Naturally occurring in citrus fruits, citric acid is categorized as a weak organic acid, which may exist both as a monohydrate or in an anhydrous form.
Zahed Mohammadi +4 more
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Heliyon, 2021 Recent studies have reported that plasma levels of tricarboxylic acid (TCA) cycle metabolites and TCA cycle-related metabolite change in patients with chronic fatigue syndrome (CFS) and in healthy humans after exercise.
Yurie Hara +3 more
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Frontiers in Plant Science, 2023 Citric acid is the primary organic acid that affects the taste of strawberry fruit. Glycolysis supplies key substrates for the tricarboxylic acid cycle (TCA cycle).
Min Yang +18 more
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Frontiers in Plant Science, 2023 Oryza Sativa is one of the most important food crops in China, which is easily affected by drought during its growth and development. As a member of the calcium signaling pathway, CBL-interacting protein kinase (CIPK) plays an important role in plant ...
Shuai Lu +9 more
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