Discovery of a second citric acid cycle complex [PDF]
Heliyon, 2023 Together, Nobel Prize honoured work, mathematics, physics and the laws of nature have drawn a concept of clockwise cycling carboxylic acids in Krebs’ Citric Acid Cycle. A Citric Acid Cycle complex is defined by specific substrate, product and regulation.
Dirk Roosterman, Graeme Stuart Cottrell
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Citric acid cycle and the origin of MARS. [PDF]
Trends Biochem Sci, 2013 The vertebrate multiaminoacyl tRNA synthetase complex (MARS) is an assemblage of nine aminoacyl tRNA synthetases (ARSs) and three non-synthetase scaffold proteins, aminoacyl tRNA synthetase complex-interacting multifunctional protein (AIMP)1, AIMP2, and AIMP3.
Eswarappa SM, Fox PL.
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Changes in TCA cycle and TCA cycle-related metabolites in plasma upon citric acid administration in rats [PDF]
Heliyon, 2021 Recent studies have reported that plasma levels of tricarboxylic acid (TCA) cycle metabolites and TCA cycle-related metabolite change in patients with chronic fatigue syndrome (CFS) and in healthy humans after exercise.
Yurie Hara +3 more
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Identification of a Classical Mutant in the Industrial Host Aspergillus niger by Systems Genetics: LaeA Is Required for Citric Acid Production and Regulates the Formation of Some Secondary Metabolites [PDF]
G3: Genes, Genomes, Genetics, 2016 The asexual filamentous fungus Aspergillus niger is an important industrial cell factory for citric acid production. In this study, we genetically characterized a UV-generated A.
Jing Niu +8 more
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Functional exploration of co-expression networks identifies a nexus for modulating protein and citric acid titres in Aspergillus niger submerged culture [PDF]
Fungal Biology and Biotechnology, 2019 Background Filamentous fungal cell factories are used to produce numerous proteins, enzymes, and organic acids. Protein secretion and filamentous growth are tightly coupled at the hyphal tip.
Timothy C. Cairns +6 more
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Environmental Chemistry and EcotoxicologyThe 6-PPD quinone (6-PPDQ) is derived from 6-PPD, an antioxidant added in tires. Citric acid cycle plays a pivotal role in biochemical metabolisms. In Caenorhabditis elegans, we examined effect of 6-PPDQ exposure on citric acid cycle and the role of ...
Xin Wan, Geyu Liang, Dayong Wang
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Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle [PDF]
Nature Communications, 2018 The citric acid cycle (TCA) is a fundamental metabolic pathway to release stored energy in living organisms. Here, the authors report two linked cycles of reactions that each oxidize glyoxylate into CO2 and generate intermediates shared with the modern ...
Greg Springsteen +4 more
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Abiotic origin of the citric acid cycle intermediates. [PDF]
Proc Natl Acad Sci U S AThe molecular framework for protometabolism—chemical reactions in a prebiotic environment preceding modern metabolism—has remained unknown in evolutionary biology. Mono-, di-, and tricarboxylic acids that comprise contemporary metabolism, such as the Krebs cycle, are of particular prebiotic relevance and are theorized to predate life on Earth ...
McAnally M +6 more
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Hgt17-Adr1 Relationship in Candida albicans Citrate Utilization [PDF]
Journal of FungiThe fungal pathogen Candida albicans can infect diverse tissues, a reflection of its broad metabolic repertoire. The transcription factor Adr1 is required for utilization of several citric acid cycle intermediates that are found in tissue.
Amelia M. White, Aaron P. Mitchell
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Characterization of pyruvate metabolism and citric acid cycle patterns predicts response to immunotherapeutic and ferroptosis in gastric cancer. [PDF]
Cancer Cell Int, 2022 Wang X +11 more
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