Results 1 to 10 of about 346,140 (362)

Discovery of a second citric acid cycle complex [PDF]

Heliyon, 2023
Together, Nobel Prize honoured work, mathematics, physics and the laws of nature have drawn a concept of clockwise cycling carboxylic acids in Krebs’ Citric Acid Cycle. A Citric Acid Cycle complex is defined by specific substrate, product and regulation.
Dirk Roosterman, Graeme Stuart Cottrell
doaj   +6 more sources

Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle [PDF]

Nature Communications, 2018
The citric acid cycle (TCA) is a fundamental metabolic pathway to release stored energy in living organisms. Here, the authors report two linked cycles of reactions that each oxidize glyoxylate into CO2 and generate intermediates shared with the modern ...
Greg Springsteen, Jayasudhan Reddy Yerabolu, Julia Nelson, Chandler Joel Rhea, Ramanarayanan Krishnamurthy   +4 more
doaj   +3 more sources

Citric acid cycle and the origin of MARS. [PDF]

Trends Biochem Sci, 2013
The vertebrate multiaminoacyl tRNA synthetase complex (MARS) is an assemblage of nine aminoacyl tRNA synthetases (ARSs) and three non-synthetase scaffold proteins, aminoacyl tRNA synthetase complex-interacting multifunctional protein (AIMP)1, AIMP2, and AIMP3.
Eswarappa SM, Fox PL.
europepmc   +6 more sources

Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients

EBioMedicine, 2017
Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology.
Stein Hallan, Maryam Afkarian, Leila R. Zelnick, Bryan Kestenbaum, Shoba Sharma, Rintaro Saito, Manjula Darshi, Gregory Barding, Daniel Raftery, Wenjun Ju, Matthias Kretzler, Kumar Sharma, Ian H. de Boer   +12 more
doaj   +3 more sources

Identification of a Classical Mutant in the Industrial Host Aspergillus niger by Systems Genetics: LaeA Is Required for Citric Acid Production and Regulates the Formation of Some Secondary Metabolites [PDF]

G3: Genes, Genomes, Genetics, 2016
The asexual filamentous fungus Aspergillus niger is an important industrial cell factory for citric acid production. In this study, we genetically characterized a UV-generated A.
Jing Niu, Mark Arentshorst, P. Deepa S. Nair, Ziyu Dai, Scott E. Baker, Jens C. Frisvad, Kristian F. Nielsen, Peter J. Punt, Arthur F.J. Ram   +8 more
doaj   +4 more sources

Functional exploration of co-expression networks identifies a nexus for modulating protein and citric acid titres in Aspergillus niger submerged culture [PDF]

Fungal Biology and Biotechnology, 2019
Background Filamentous fungal cell factories are used to produce numerous proteins, enzymes, and organic acids. Protein secretion and filamentous growth are tightly coupled at the hyphal tip.
Timothy C. Cairns, Claudia Feurstein, Xiaomei Zheng, Li Hui Zhang, Ping Zheng, Jibin Sun, Vera Meyer   +6 more
doaj   +3 more sources

6-PPD quinone at environmentally relevant concentrations disrupts citric acid cycle in Caenorhabditis elegans: Role of reduction in acetyl CoA and pyruvate contents

Environmental Chemistry and Ecotoxicology
The 6-PPD quinone (6-PPDQ) is derived from 6-PPD, an antioxidant added in tires. Citric acid cycle plays a pivotal role in biochemical metabolisms. In Caenorhabditis elegans, we examined effect of 6-PPDQ exposure on citric acid cycle and the role of ...
Xin Wan, Geyu Liang, Dayong Wang
doaj   +2 more sources

Impaired Citric Acid Cycle in Nondiabetic Chronic Kidney Disease [PDF]

EBioMedicine, 2017
Zhanjun Jia
doaj   +2 more sources

A STUDY OF THE CITRIC ACID CYCLE IN ERYTHROCYTES

Journal of Biological Chemistry, 1958
Rashid M. Dajani, James M. Orten
openalex   +3 more sources

A CITRIC ACID CYCLE IN PROPIONIBACTERIUM PENTOSACEUM

Journal of Bacteriology, 1953
E. A. Delwiche, S. F. Carson
openalex   +4 more sources