Results 101 to 110 of about 310,804 (186)

Biosensor analysis of anti citrullinated protein/peptide antibodies (ACPA) affinity

, 2014
Anti-citrullinated protein/peptide antibodies (ACPAs) are detected in rheumatoid arthritis (RA) sera and because of their strict association with the disease are considered marker antibodies, probably endowed with pathogenic potential.
Rossi G, MIGLIORINI, PAOLA, PRATESI, FEDERICO, Real Fernandez F, Rovero P, PANZA, FILOMENA   +5 more
core   +1 more source

Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage.

PLoS ONE, 2016
BackgroundRheumatoid arthritis (RA) is an autoimmune disease of the synovial joints. The autoimmune character of RA is underscored by prominent production of autoantibodies such as those against IgG (rheumatoid factor), and a broad array of joint tissue ...
Tibor T Glant, Timea Ocsko, Adrienn Markovics, Zoltan Szekanecz, Robert S Katz, Tibor A Rauch, Katalin Mikecz   +6 more
doaj   +1 more source

pH/Acetonitrile-Gradient Reversed-Phase Fractionation of Enriched Hyper-Citrullinated Library in Combination with LC-MS/MS Analysis for Confident Identification of Citrullinated Peptides. [PDF]

Methods Mol Biol, 2022
Stachowicz A, Sundararaman N, Venkatraman V, Van Eyk J, Fert-Bober J.   +4 more
europepmc   +1 more source

Defining the role of αC helix interactions in the activation of the integrin αI domain

The FEBS Journal, EarlyView.
The α2I domain of the α2β1 integrin contains a distinctive αC helix and a conserved Arg288‐Glu318 ion pair that stabilizes the closed state of the domain. Disruption of this ion pair in the activated α2I variant unwinds the αC helix, which allows interaction with additional collagen‐binding sites increasing collagen binding.
Liisa Pösö, Tomi T. Airenne, Jarmo Käpylä, Hongmin Tu, Eva Bligt‐Lindén, Vimal Parkash, Jyrki Heino, Tiina A. Salminen   +7 more
wiley   +1 more source

Antibodies to cyclic citrullinated peptides in psoriatic arthritis

, 2005
To determine the presence and clinical significance of antibodies to cyclic citrullinated peptides (anti-CCP) in psoriatic arthritis (PsA)
Alpini, Claudia, Montecucco, Carlomaurizio, Bogliolo, Laura, Scirè, Carlo Alberto, Caporali, Roberto, Moratti, Remigio   +5 more
core  

Direct transition to a streamlined rheumatoid arthritis clinic improves outcomes after discharge from an early arthritis clinic environment

Internal Medicine Journal, EarlyView.
Abstract Background The treat‐to‐target (T2T) strategy for the management of rheumatoid arthritis (RA) achieves remission or low disease activity in many patients. However, RA T2T is challenging in real‐world clinical environments. In this two‐stage audit, we evaluated the impact of transferring patients from a T2T intensive early arthritis clinic (EAC)
Hyunjun Jonathan Kim, Mitsi Blazos, Kevin Yen Chia Su, Ranjeny Thomas, Helen Benham   +4 more
wiley   +1 more source

Factor reumatoideo, anticuerpos antipéptidos citrulinados y actividad de la enfermedad en pacientes con artritis reumatoidea

Revista Habanera de Ciencias Médicas, 2015
Introducción: la artritis reumatoidea es una enfermedad inflamatoria crónica y multisistémica de causa autoinmune.Los anticuerpos antipéptidos citrulinados constituyen una herramienta importante para el diagnóstico de esta enfermedad.
Goitybell Martínez Téllez, Jorge Alexis Gómez, Vicky Sánchez Rodríguez, Cira Rodríguez Pelier, Bárbara Torres Rives, Ana María Torres Lima   +5 more
doaj  

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Diffuse Skin Sclerosis in a Patient With Lung Cancer

JEADV Clinical Practice, EarlyView.
Anna‐Sophia Leven, Eva Hadaschik, Alpaslan Tasdogan   +2 more
wiley   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source