Results 141 to 150 of about 6,340 (217)

The TG2/LRP1 Pathway for T Cell Activation by Post‐Translationally Modified Antigens

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Post‐translational modifications (PTMs) can generate neo‐epitopes, modified peptides that evade immune tolerance and trigger immune responses. This review focuses on the TG2/LRP1 pathway as a new paradigm for coupling the formation of post‐translationally modified peptides with their effective presentation as T‐cell antigens by dendritic cells.
Agnele Sylvia Sewa, Fu‐Chen Yang, Chaitan Khosla   +2 more
wiley   +1 more source

Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen‐Driven Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Citrullination and deamidation are post‐translational modifications (PTMs) increasingly recognized as important contributors to neoepitope formation in type 1 diabetes (T1D). Under inflammatory and endoplasmic reticulum stress conditions, beta cells activate calcium‐dependent peptidylarginine deiminase and transglutaminase enzymes, leading to ...
Aïsha Callebaut, Ylke Bruggeman, Chantal Mathieu, Eddie A. James, Lut Overbergh   +4 more
wiley   +1 more source

Hypoxia‐preconditioned adipose‐derived mesenchymal stem cells‐derived exosomes transferring H19 obstruct neutrophil extracellular traps formation via HOXA5‐mediated inactivation of TLR4/NF‐κB/NLRP3 inflammatory signaling

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1283-1303, August 2026.
In this study, we uncovered that Hypo‐Exo transferring H19 promoted diabetic wound healing by repressing NETs formation via the miR‐130a/b‐3p/HOXA5 pathway to inactivate the TLR4/NF‐κB/NLRP3 inflammatory signaling. ABSTRACT Background Hypoxia‐stimulated adipose‐derived mesenchymal stem cells (ADSCs)‐derived exosomes (Hypo‐Exo) have a positive impact on
Li Qian, Xianxi Meng, Bairong Fang, Li Pi   +3 more
wiley   +1 more source

Supporting data for the MS identification of distinct transferrin glycopeptide glycoforms and citrullinated peptides associated with inflammation or autoimmunity. [PDF]

Data Brief, 2016
Rosal-Vela A, Barroso A, Giménez E, García-Rodríguez S, Longobardo V, Postigo J, Iglesias M, Lario A, Merino J, Merino R, Zubiaur M, Sanz-Nebot V, Sancho J.   +12 more
europepmc   +1 more source

HLA-DR risk variants in rheumatoid arthritis: what we know and still do not know. [PDF]

RMD Open
Yap CF, Viatte S.
europepmc   +1 more source

Cyclic Citrullinated Peptide Antibody Measurement [PDF]

, 2020
openaire   +1 more source

Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes. [PDF]

Chembiochem
Borbély A, Steckel A, Papp D, Pál D, Uray K, Gőz VG, Schlosser G.   +6 more
europepmc   +1 more source

Development of motif-specific monoclonal antibodies for global protein citrullination detection with minimal cross-reactivity to homocitrullination. [PDF]

Cell Rep Methods
Laposchan S, Riedel E, Flatley A, Pasquero S, Feederle R, Lee CY.   +5 more
europepmc   +1 more source

Circulating secretory IgA antibodies against cyclic citrullinated peptides in early rheumatoid arthritis associate with inflammatory activity and smoking. [PDF]

Arthritis Res Ther, 2016
Roos K, Martinsson K, Ziegelasch M, Sommarin Y, Svärd A, Skogh T, Kastbom A.   +6 more
europepmc   +1 more source

High-throughput chemical proteomics workflow for profiling protein citrullination dynamics. [PDF]

Nat Commun
Meelker González R, Laposchan S, Riedel E, Fürst A, O'Sullivan N, Gabriel W, Wilhelm M, Knolle PA, Médard G, Kuster B, Lee CY.   +10 more
europepmc   +1 more source