Results 71 to 80 of about 12,205 (240)

Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis

Frontiers in Immunology, 2016
Antibodies to citrullinated proteins, common in rheumatoid arthritis (RA) patients, are strongly associated to a specific set of HLA-DR alleles including HLA-DRB1*04:01, *04:04, and *01:01.
Christina Gerstner, Anatoly Dubnovitsky, Anatoly Dubnovitsky, Charlotta Sandin, Genadiy Kozhukh, Genadiy Kozhukh, Hannes Uchtenhagen, Hannes Uchtenhagen, Eddie A. James, Johan Rönnelid, Anders Jimmy Ytterberg, Anders Jimmy Ytterberg, Jennifer Pieper, Evan Reed, Karolina Tandre, Mary Rieck, Roman A. Zubarev, Lars Rönnblom, Tatyana Sandalova, Tatyana Sandalova, Jane H. Buckner, Adnane Achour, Adnane Achour, Vivianne Malmström   +23 more
doaj   +1 more source

Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis

RMD Open, 2020
Background Rheumatoid arthritis (RA)-associated anticitrullinated protein/peptide antibodies (ACPA) might originate at mucosal sites such as the lungs.
Katerina Chatzidionysiou, Magnus Sköld, Monica Hansson, Guy Serre, Vijay Joshua, Aase Haj Hensvold, Gudrun Reynisdottir, Martin Cornillet, Leonor Nogueira, Sven Nyren, Reza Karimi, Anders Eklund, Johan Grunewald, Anca Catrina   +13 more
doaj   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Citrullinated Antigens with Multiple Citrulline Similar Motif in the Diagnosis of Rheumatoid Arthritis: A Preliminary Single-Center Study

Journal of Immunology Research, 2021
The presence of anti-citrullinated protein antibodies (ACPAs) in the serum is one of the immunological features of rheumatoid arthritis (RA). Anti-cyclic citrullinated peptide (CCP) assay has been widely used in clinic for the diagnosis of RA.
Zhu Chen, Weiting Fang, Yi Qin, Yin-Zhao Jin, Xiang Yang, Jianrong Lou   +5 more
doaj   +1 more source

Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients [PDF]

, 2017
BACKGROUND: Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune system contributes to the development
Alessandri, Cristiano, Ciciarello, Francesco Luigi, Colasanti, Tania, Conti, Fabrizio, DI FRANCO, Manuela, Miranda, Francesca, Pecani, Arbi, Spinelli, FRANCESCA ROMANA, Valesini, Guido   +8 more
core   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis [PDF]

, 2015
Introduction: Patients with rheumatoid arthritis (RA) can be separated into two major subpopulations based on the absence or presence of serum anti-citrullinated protein antibodies (ACPAs).
Davelaar, N. (Nadine), Hamburg, J.P. (Jan Piet) van, Hazes, J.M.W. (Mieke), Jong, P.H.P. (Pascal) de, Lubberts, E.W. (Erik), Paulissen, S.M.J. (Sandra), Vroman, H. (Heleen)   +6 more
core   +1 more source

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis. [PDF]

PLoS ONE, 2016
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting the joints. Anti-citrullinated protein antibodies (ACPA) are frequently found in RA.
Adrienn Markovics, Tímea Ocskó, Robert S Katz, Edit I Buzás, Tibor T Glant, Katalin Mikecz   +5 more
doaj   +1 more source