Results 121 to 130 of about 55,491 (303)

Early Detection and Diagnosis of Neonatal Intrahepatic Cholestasis Caused by Citrin Deficiency Missed by Newborn Screening Using Tandem Mass Spectrometry

International Journal of Neonatal Screening, 2018
Citrullinemia is the earliest identifiable biochemical abnormality in neonates with intrahepatic cholestasis due to a citrin deficiency (NICCD) and it has been included in newborn screening panels using tandem mass spectrometry. However, only one neonate
Hiroko Shigetomi, Toju Tanaka, Masayoshi Nagao, Hiroyuki Tsutsumi   +3 more
doaj   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Factors affecting the production of putrescine from agmatine by Lactobacillus hilgardii X1B isolated from wine [PDF]

, 2008
Aims: To elucidate and characterize the metabolic putrescine synthesis pathway from agmatine by Lactobacillus hilgardii X1B. Methods and Results: The putrescine formation from agmatine by resting cells (the normal physiological state in wine) of lactic ...
Adams, Anli, Arena, Arena, Arena, Arena, Arena, Babu, Bardocz, Bauza, Blasco, Bover-Cid, Brodequis, Buteau, Coton, Dicks, Donhauser, Farías, Farías, Glória, Glória, González-Fernández, Guerrini, Joosten, Kalač, Landete, Lehtonen, Leitão, Lima, Liu, Liu, Lounvaud-Funel, Lu, Maijala, Mangani, Marcobal, Peatfield, Pilone, Radler, Radler, Sekowska, Simon, Soufleros, Strasser de Saad, Straub, ten Brink, Vidal-Carou, Woller   +47 more
core   +1 more source

Conserved Citrullinating Exoenzymes inPorphyromonasSpecies

Journal of Dental Research, 2018
Porphyromonas gingivalis is one of the major oral pathogens implicated in the widespread inflammatory disorder periodontitis. Moreover, in recent years, P. gingivalis has been associated with the autoimmune disease rheumatoid arthritis. The peptidylarginine deiminase enzyme of P.
Gabarrini, G., Chlebowicz, M.A., Vega Quiroz, M.E., Veloo, A.C.M., Rossen, J.W.A., Harmsen, H.J.M., Laine, M.L., van Dijl, J.M., van Winkelhoff, A.J.   +8 more
openaire   +6 more sources

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott, Katrin Bennewitz, Xin Zhang, Mariia Prianichnikova, Carsten Sticht, Gernot Poschet, Jens Kroll   +6 more
wiley   +1 more source

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source

Biochemical, physiological, and performance response of a functional watermelon juice enriched in L-citrulline during a half-marathon race [PDF]

, 2017
Background: Watermelon is a rich natural source of l-citrulline. This non-essential amino acid increases exercise performance. Objective: Evaluate the effect of Fashion watermelon juice enriched in l-citrulline (CWJ) (3.45 g per 500 mL) in physical ...
Armstrong RB, Ascensión Martínez-Sánchez, Bendahan D, Borg G, Bárbara Fernández-Lobato, Calbet JA, Callis A, Cribb PJ, Del Coso J, Del Coso JD, Del Coso JD, Domingo J. Ramos-Campo, Encarna Aguayo, Fernando Alacid, Glenn JM, Hellsten Y, Hickner RC, Hill DW, Jacobo A. Rubio-Arias, Kirby TJ, Lappalainen H, Leers MPG, Machado M, Mastaloudis A, Meneguello MO, Munjal DD, Murray RK, Mutch BJ, Petrovic V, Pettersson J, Pérez-Guisado J, Ramos-Campo DJ, Steed J, Sureda A, Suzuki T, Takeda K, Tarazona-Díaz MP, Urdampilleta A, Urdampilleta A, Wax B, Williams MH, Wu G   +41 more
core   +2 more sources

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

An Overview of Liquid Chromatography–Mass Spectrometry (LC–MS) Methods for the Quantification of Antibody‐Drug Conjugates

Biomedical Chromatography, Volume 40, Issue 2, February 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) are innovative drugs composed of cytotoxic molecules (payload) linked to antibodies, that selectively target and kill cancer cells upon internalization. In vivo, ADCs exist as intact molecules, naked antibodies, or released, unconjugated (linker‐)payload.
Pauline L. M. Buitelaar, Hilde Rosing, Jos H. Beijnen, Neeltje Steeghs, Alwin D. R. Huitema   +4 more
wiley   +1 more source

L-Citrullinato-Bipyridine and L-Citrullinato-Phenanthroline Mixed Copper Complexes: Synthesis, Characterization and Potential Anticancer Activity

Pharmaceutics
Citrulline (C6H13N3O3) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations.
Diego Ramírez-Contreras, Sergio Vázquez-Rodríguez, Amalia García-García, Lisset Noriega, Angel Mendoza, Brenda L. Sánchez-Gaytán, Francisco J. Meléndez, María Eugenia Castro, Maura Cárdenas-García, Enrique González-Vergara   +9 more
doaj   +1 more source