Results 121 to 130 of about 51,040 (246)

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott   +6 more
wiley   +1 more source

Ornithine-catalyzed urea formation in liver homogenate [PDF]

open access: yes, 1947
Heretofore attempts to obtain synthesis of urea from ammonia (and carbon dioxide) in cell-free extracts have been unsuccessful. We have found the reaction to proceed in guinea pig liver homogenate.
Borsook, Henry, Dubnoff, Jacob W.
core  

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet   +6 more
wiley   +1 more source

L-Citrullinato-Bipyridine and L-Citrullinato-Phenanthroline Mixed Copper Complexes: Synthesis, Characterization and Potential Anticancer Activity

open access: yesPharmaceutics
Citrulline (C6H13N3O3) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations.
Diego Ramírez-Contreras   +9 more
doaj   +1 more source

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1057-1069, April 2026.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka   +12 more
wiley   +1 more source

Potential Use of Compatible Osmolytes as Drought Tolerance Indicator in Local Watermelon (Citrullus lanatus) Landraces

open access: yesHorticulturae
Watermelons are one of the most important crop species, and they are enjoyed across the globe; however, the cultivation of watermelon commercial varieties in arid regions is challenging, as they are highly susceptible to water deficit.
Lesego T. Sewelo   +4 more
doaj   +1 more source

In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype. [PDF]

open access: yes, 2018
Following injury, mesenchymal repair cells are activated to function as leader cells that modulate wound healing. These cells have the potential to differentiate to myofibroblasts, resulting in fibrosis and scarring.
Alnwibit, A. A.   +4 more
core   +1 more source

Analyzing Nicotine Action Against Amyloid Toxicity by NMR‐Pharmacometabolomics: An Exploratory Study

open access: yesNMR in Biomedicine, Volume 39, Issue 4, April 2026.
Combined metabolomic analysis of the intracellular and extracellular portions of SH‐SY5Y cells revealed that, in the presence of Aβ 1–42, nicotine primarily influences pathways related to neurotransmission, energy metabolism, as well as the biosynthesis and degradation of membrane phospholipids.
Enza Napolitano   +5 more
wiley   +1 more source

Citrulline Is an Important Biochemical Indicator in Tolerance to Saline and Drought Stresses in Melon

open access: yesThe Scientific World Journal, 2013
Salt- and drought-induced alterations in citrulline were assessed in 4 local melon genotypes, 2 sensitive (CU-52, CU-94) and 2 tolerant (CU-196, CU-280), grown in vermiculite in a growth chamber.
Sebnem Kusvuran   +2 more
doaj   +1 more source

The formation of glycocyamine in animal tissues [PDF]

open access: yes, 1941
It was shown in preceding communications that glycocyamine is converted into creatine by surviving liver slices (1). Our findings indicated that the methylating agent is methionine or a derivative of methionine.
Borsook, Henry, Dubnoff, Jacob W.
core  

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