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Citrullination and Autoimmunity
Autoimmunity Reviews, 2015Autoimmune diseases are characterized by the body's own immune system attack to the self-tissues, a condition enabled, in predisposed subjects, by the reduction of self-tolerance. A central role has been recently recognized to post-translational modifications, since they can promote generation of neo-(auto)antigens and in turn an autoimmune response ...
VALESINI, Guido +5 more
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Citrulline metabolism in plants
Amino Acids, 2017Citrulline was chemically isolated more than 100 years ago and is ubiquitous in animals, plants, bacteria, and fungi. Most of the research on plant citrulline metabolism and transport has been carried out in Arabidopsis thaliana and the Cucurbitaceae family, particularly in watermelon which accumulates this non-proteinogenic amino acid to very high ...
Vijay Joshi, Alisdair R. Fernie
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Citrulline utilization in Crithidia
Biochemical and Biophysical Research Communications, 1966It was early noted in growth studies (Kidder and Dutta, 1958) that the trypanosomid flagellate Crithidia fasciculata could utilize citrulline, but not ornithine, as a replacement for arginine . A somewhat more efficient use of citrulline than arginine suggested that citrulline might be contributing directly to reactions other than just the production ...
G W, Kidder, J S, Davis, K, Cousens
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Current Opinion in Clinical Nutrition and Metabolic Care, 2007
Citrulline, a nonprotein amino acid, is an important source of endogenous arginine. The gut is the main source of citrulline in humans. Hence, citrulline is a potential biomarker of short bowel function. Conversely, citrulline uptake by the gut is important for an oral supply of this amino acid as an alternative to arginine. This review discusses these
Emmanuel, Curis +2 more
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Citrulline, a nonprotein amino acid, is an important source of endogenous arginine. The gut is the main source of citrulline in humans. Hence, citrulline is a potential biomarker of short bowel function. Conversely, citrulline uptake by the gut is important for an oral supply of this amino acid as an alternative to arginine. This review discusses these
Emmanuel, Curis +2 more
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Biologically Active Citrulline Peptides
Nature, 1962To the best of our knowledge no peptides have so far been synthesized with citrulline as a building component. This alone could be sufficient reason to study citrulline peptides, but our investigations were prompted by other considerations as well.
M, BODANSZKY +6 more
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Citrulline synthesis in rat tissues
Archives of Biochemistry and Biophysics, 1961Abstract The distribution of carbamyl phosphate synthetase (CPS) and/or ornithine transcarbamylase (OTC) was determined in 17 different rat tissues. Both enzymes, but particularly OTC, were found to be located mainly in the liver so that assay for OTC activity can provide a highly specific test for liver parenchymal cells.
M E, JONES +3 more
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Citrullinated proteins in Rheumatoid Arthritis
Reumatología Clínica (English Edition), 2011Rheumatoid arthritis is an autoimmune disease of multifactorial etiology characterized by inflammation of the joints and presence of autoantibodies directed against multiple autoantigens. Recently the study of the anti-citrullinated protein antibodies (ACP) has acquired great interest due to its high specificity and sensitivity for diagnosis, in ...
Elizabeth, Olivares Martínez +3 more
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Citrullinated proteins in rheumatoid arthritis
Frontiers in Bioscience, 2005Citrullinated proteins that are produced by enzymatic deimination of arginine residues in proteins by peptidylarginine deiminases (PADIs) are of particular interest in the pathogenesis of rheumatoid arthritis (RA). First, peptidylarginine deiminase type 4 (PADI4) gene, which codes one of the PADI enzyme isotypes, has a genetic variant that increases ...
Ryo, Yamada +3 more
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