Results 61 to 70 of about 32,902 (265)

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

The antibiotic resistance of Helicobacter pylori to five antibiotics and influencing factors in an area of China with a high risk of gastric cancer

BMC Microbiology, 2019
Background H. pylori exhibits antibiotic resistance with regional differences. In this paper, we explored antibiotic resistance of H. pylori to five antibiotics in an area with a high risk of gastric cancer. Results H.
Dan Wang, Qianqian Guo, Yuan Yuan, Yuehua Gong   +3 more
doaj   +1 more source

\u3cem\u3eHelicobacter pylori\u3c/em\u3e infection in Havana, Cuba. Prevalence and \u3cem\u3ecagA\u3c/em\u3e status of the strains [PDF]

, 2005
There is a great paucity of information about Helicobacter pylori infection in the countries of the Caribbean basin. Almost no studies have been performed to determine the prevalence, antibiotic resistance or virulence factors of the bacterium.
Camou-Juncas, Christine, del Pilar Escobar, María, Díaz-Canel, Osvaldo, González, Nery, Gutiérrez, Beatriz, Leonard, Ibrahim, Martínez, Rolando, Mendz, George L, Mégraud, Françis, Paniagua, Manuel, Santos, Adriana, Valmaña, Carlos Ernesto, Vidal, Teresita   +12 more
core   +1 more source

Efficacy of Clarithromycin against Experimentally Induced Pneumonia Caused by Clarithromycin-Resistant Haemophilus influenzae in Mice [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT Clarithromycin is a 14-member lactone ring macrolide with potent activity against Haemophilus influenzae , including ampicillin-resistant strains. We evaluated the in vivo efficacy of clarithromycin at 40 mg/day and 100 mg/day for 3 days in the treatment of a murine model ...
Shigeki, Nakamura, Katsunori, Yanagihara, Nobuko, Araki, Koichi, Yamada, Yoshitomo, Morinaga, Koichi, Izumikawa, Masafumi, Seki, Hiroshi, Kakeya, Yoshihiro, Yamamoto, Shimeru, Kamihira, Shigeru, Kohno   +10 more
openaire   +2 more sources

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

Assessment and analysis of H.pylori infection treatment strategies of St. Vincent Hospital\u27s family and internal medicine clinics [PDF]

, 2019
Helicobacter pylori is a gram-negative bacteria that is responsible for causing chronic gastritis, ulcers in the stomach and intestine, and eventually even gastric lymphoma or cancer.
Orr, Rebecca
core   +1 more source

Advance in Helicobacter pylori resistance to clarithromycin

World Chinese Journal of Digestology, 2008
Helicobacter pylori (H pylori) infection is the main cause of chronic active gastritis and peptic ulcer disease, and studies indicated eradication of H pylori could promote the healing of peptic ulcer. H pylori resistance to clarithromycin, which shows an increasing tendency year by year, is related with mutations of H pylori 23S rRNA domain V ...
Shi-Hai Xuan, Yu-Gui Zhou, Hui-Min Wang
openaire   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Clarithromycin-based Helicobacter pylori eradication therapy is not associated with higher treatment failure compared with non-clarithromycin-based regimens in a tertiary referral hospital in Switzerland

Swiss Medical Weekly, 2023
BACKGROUND AND AIMS: Due to increasing antibiotic resistance, various Helicobacter pylori eradication regimens other than clarithromycin-based therapies have been proposed.
Tobias Braendli, Valeria Schindler, Dominique Laurent Braun, Fritz R. Murray, Juliane Marie Hente, Daniel Pohl   +5 more
doaj   +1 more source

Changes of Interleukins in Patients with Nosocomial Pneumonia Against a Background of Traumatic Brain Injury: Role in the Diagnosis and Monitoring of Disease [PDF]

, 2017
Introduction. Nosocomial pneumonia (NP) is the second leading frequency and mortality among nosocomial infections. NP is a frequent complication of severe traumatic brain injury (TBI).
Ilchenko, A. (Anastasiia)
core   +2 more sources