Results 51 to 60 of about 18,197 (177)

Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis [PDF]

The Korean Journal of Internal Medicine, 2019
Background/Aims The eradication rate of the first-line triple therapy (a proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has gradually decreased in Korea.
Young Woon Chang, Weon Jin Ko, Chi Hyuk Oh, Yoo Min Park, Shin Ju Oh, Jung Rock Moon, Jun-Hyung Cho, Jung-Wook Kim, Jae-Young Jang   +8 more
doaj   +1 more source

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

Advance in Helicobacter pylori resistance to clarithromycin

World Chinese Journal of Digestology, 2008
Helicobacter pylori (H pylori) infection is the main cause of chronic active gastritis and peptic ulcer disease, and studies indicated eradication of H pylori could promote the healing of peptic ulcer. H pylori resistance to clarithromycin, which shows an increasing tendency year by year, is related with mutations of H pylori 23S rRNA domain V ...
Shi-Hai Xuan, Yu-Gui Zhou, Hui-Min Wang
openaire   +1 more source

Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug–Drug Interactions for Orforglipron, a Small Molecule Glucagon‐Like Peptide‐1 Receptor Agonist

Clinical Pharmacology &Therapeutics, EarlyView.
Orforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Bridget L. Morse, David E. Coutant, Xiaosu Ma, Sohini Raha, Keerthan Aithal, Clare Nicoll, Luc R. A. Rougée, Shobha Bhattachar   +7 more
wiley   +1 more source

Clarithromycin Resistance and Eradication of Helicobacter pylori in Children [PDF]

Antimicrobial Agents and Chemotherapy, 2001
ABSTRACT Outcome of Helicobacter pylori infection was analyzed in 61 children treated with a triple therapy including clarithromycin. Bacterial eradication was obtained in all children with clarithromycin-susceptible strains but not in children with clarithromycin-resistant ones ( P
N, Kalach, P H, Benhamou, F, Campeotto, M, Bergeret, C, Dupont, J, Raymond   +5 more
openaire   +2 more sources

Primary clarithromycin resistance in Helicobacter pylori: the Multicentric Italian Clarithromycin Resistance Observational (MICRO) study.

Journal of gastrointestinal and liver diseases : JGLD, 2011
Primary clarithromycin resistance markedly reduces Helicobacter pylori eradication rate following standard therapies. Prevalence of primary clarithromycin resistance in H. pylori is increasing, and three point mutations are mainly involved. AIM. To assess both the prevalence of primary clarithromycin resistance in Italy, and the distribution of the ...
De Francesco V, Giorgio F, Ierardi E, Zotti M, Neri M, Milano A, Varasano V, Luzza F, Suraci E, Marmo R, Marone A, Manta R, Mirante VG, de Matthaeis M, Pedroni A, Manes G, Pallotta S, USAI, PAOLO, Liggi M, Gatto G, Peri V, Sacco R, Bresci G, Monica F, Hassan C, Zullo A.   +25 more
openaire   +3 more sources

High Prevalence of hefA Efflux Pump Overexpression in Isolates of Helicobacter pylori Resistant to Clarithromycin

Antibiotics
Background/Objectives: Helicobacter pylori is a cause of chronic gastric infections and gastrointestinal carcinogenesis, with a prevalence of 20–90% around the world.
Marcela Villegas, Catalina Ortega, Krishna Gómez, Alvaro Cerda, Rolando Sepúlveda, Christian Lara, Luis Bustamante, Daniela Garcia, Luis Coppelli, Edmundo Hofmann, Armando Sierralta, Mónica Pavez   +11 more
doaj   +1 more source

PNA-FISH as a new diagnostic method for the determination of clarithromycin resistance of Helicobacter pylori

BMC Microbiology, 2011
Background Triple therapy is the gold standard treatment for Helicobacter pylori eradication from the human stomach, but increased resistance to clarithromycin became the main factor of treatment failure.
Figueiredo Céu, Dinis-Ribeiro Mário, Carneiro Fátima, Ferreira Rui M, Fernandes Ricardo M, Cerqueira Laura, Keevil Charles W, Azevedo Nuno F, Vieira Maria J   +8 more
doaj   +1 more source

Detection of Clarithromycin-Resistant Helicobacter pylori in Stool Samples [PDF]

Journal of Clinical Microbiology, 2003
ABSTRACT The recognition of the role of Helicobacter pylori in gastric diseases has led to the widespread use of antibiotics in the eradication of this pathogen. The most advocated therapy, triple therapy, often includes clarithromycin.
FONTANA, CARLA, FAVARO, MARCO, PIETROIUSTI, ANTONIO, PISTOIA, ENRICO SALVATORE, GALANTE, ALBERTO, FAVALLI, CARTESIO   +5 more
openaire   +3 more sources

Exploring the Molecular Mechanisms of Macrolide Resistance in Laboratory Mutant Helicobacter pylori

Antibiotics
Resistance to clarithromycin, a macrolide antibiotic used in the first-line treatment of Helicobacter pylori infection, is the most important cause of treatment failure. Although most cases of clarithromycin resistance in H.
Meltem Ayaş, Sinem Oktem-Okullu, Orhan Özcan, Tanıl Kocagöz, Yeşim Gürol   +4 more
doaj   +1 more source