Results 51 to 60 of about 31,775,635 (161)

N‐(1H‐Indazolyl) Aryl Sulfonamide Hybrids as Potential Dihydropteroate Synthase Inhibitors: In Vitro Antibacterial Activity Against Escherichia coli and Staphylococcus aureus and Computational Modeling

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Sixteen indazole–sulfonamide hybrids exhibit species‐dependent antibacterial activity against E. coli and S. aureus, with the lead compound displaying an eightfold lower MIC than sulfathiazole against E. coli. Molecular docking against wild‐type and Sul1‐resistant dihydropteroate synthase identifies a candidate retaining binding affinity toward the ...
Romaisaa Boudza, Ferdaous Elandaloussi, Khalid Boujdi, Jaume Segura‐Garcia, Nabil El Brahmi, Saïd El Kazzouli, Ismaïl Moukadiri, Sergi Maicas, Salim Bounou   +8 more
wiley   +1 more source

Evidence for dynamic exchange of qac gene cassettes between class 1 integrons and other integrons in freshwater biofilms

, 2009
Class 1 integrons carried by pathogens have acquired over 100 different gene cassettes encoding resistance to antimicrobial compounds, helping to generate a crisis in the management of infectious disease.
Stokes, Harold W. W, Holley, MP, Holley, Marita, Gillings, MR, Gillings, Michael R, Stokes, HW   +5 more
core   +1 more source

Two-dimensional PCR for detecting class 1, 2 and 3 integrons

Heliyon, 2022
Integrons can capture and express foreign gene cassettes through site-specific recombination and are important genetic elements in spreading antibiotic resistance genes among bacteria.
Wenwen Zhu, Tong Wang, Yu Zhu, Linlin Xiao, Weiwei Liu, Quhao Wei   +5 more
doaj   +1 more source

Antarctic soil microbiomes encode structurally conserved and phylogenetically diverse beta‐lactamases

iMetaOmics, Volume 3, Issue 3, September 2026.
An integrative metagenomic framework combining sequence, structural, and functional inference reveals a phylogenetically diverse and structurally conserved repertoire of putative beta‐lactamases across Antarctic soil microbiomes, with predominance of class A and subclass B3 enzymes and limited but detectable associations with mobile genetic elements ...
José Coche‐Miranda, Patricio Arros, Nicolás Canales, Camilo Berríos‐Pastén, Gastón Azziz, Rosalba Lagos, Julieta Orlando, Francisco P. Chávez, Andrés E. Marcoleta   +8 more
wiley   +1 more source

Identification of Potential Vaccine Strains of Escherichia coli Isolates From Diarrhoeic Calves

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This study aimed to identify vaccine candidate Escherichia coli strains isolated from diarrheic calves. Faecal samples collected from 500 calves were analysed, and E. coli strains were isolated and characterized phenotypically and genotypically. Antibiotic resistance profiles, virulence‐associated genes and MLVA genotyping were used to select 20 ...
Yasemin Erdoğan, Ediz Kağan Özgen, Murat Özmen, Elif Karadeniz Pütür, Nebahat Polat, Ersan Pütür, Mücahit Harmancı, Ercan Atalay, Ahmet Temur, Meryem Güloğlu, Lütfullah Celep, Seyda Cengiz, Mehmet Cemal Adıgüzel, Cihan Öz, Timur Gülhan, Alper Çiftci, Erhan Çiftgül   +16 more
wiley   +1 more source

Occurance and characteristics of class 1, 2 and 3 integrons in Escherichia coli, Salmonella and Campylobacter spp. in the Netherlands

, 2007
Objectives: To determine the occurrence and transmission of class 1, 2 and 3 integrons in multidrug-resistant or sulfamethoxazole-resistant Salmonella from human and animal sources and in Campylobacter spp.
Smith, H.E., Veldman, K.T., Mevius, D.J., van Essen-Zandbergen, A.   +3 more
core   +1 more source

Identification and characterization of class 1 integrons among Pseudomonas aeruginosa isolates from patients in Zhenjiang, China [PDF]

, 2009
SummaryObjectivesThe role of integrons in the spread of antibiotic resistance has been well established. The aim of this study was to investigate the resistance profiles of Pseudomonas aeruginosa isolated from patients in Zhenjiang to 13 antibiotics, and
Wen, Ping, Dai, Xiaoli, Peng, Sufang, Su, Zhaoliang, Liu, Yingzhao, Huang, Xinxiang, Li, Yazhen, Shao, Qixiang, Wang, Shengjun, Xu, Huaxi, Chen, Jianguo, Zhang, Haifang, Yu, Jianren   +12 more
core   +1 more source

Characterization of antibiotic resistance integrons harbored by Romanian Escherichia coli uropathogenic strains

Romanian Journal of Laboratory Medicine, 2020
Because little is known about the integrons which constitute an important means of spreading resistance in bacteria circulating in Romania, this study aimed to detect antibiotic resistance gene cassettes embedded in integrons in a convenient collection ...
Oprea Mihaela, Militaru Madalina Cornelia, Ciontea Adriana Simona, Cristea Daniela, Cristea Violeta, Usein Codruta Romanita   +5 more
doaj   +1 more source

Restoring Meropenem Activity Against VIM‐1‐Producing Klebsiella pneumoniae Through Zinc‐Binding Ligands

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
Approved zinc‐binding drugs and newly synthesized HisPyr ligands were evaluated as adjuvants to meropenem against metallo‐β‐lactamase‐producing Klebsiella pneumoniae. Chlorpropamide and D‐penicillamine restored meropenem activity against the VIM‐1‐producing strain, while computational analyses supported interactions with the enzyme's binuclear zinc ...
Chiara Ragusa, Ruqaiya Khalil, Valentina Giglio, Kaveh Eskandari, Fraser J. Scott, Attilio V. Vargiu, Graziella Vecchio   +6 more
wiley   +1 more source

Occurrence and composition of class 1 and class 2 integrons in clinical and environmental O1 and non-O1/non-O139 Vibrio cholerae strains from the Brazilian Amazon

Memorias do Instituto Oswaldo Cruz, 2010
This study identified and characterised class 1 and 2 integrons in clinical and environmental Vibrio cholerae O1 and non-O1/non-O139 strains isolated from the Brazilian Amazon.
Lena Lillian Canto de Sá, Érica Lourenço da Fonseca, Maíra Pellegrini, Fernanda Freitas, Edvaldo Carlos Brito Loureiro, Ana Carolina Paulo Vicente   +5 more
doaj   +1 more source