Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. [PDF]
PLoS Pathogens, 2016 Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
Brandon L Garcia +4 more
doaj +9 more sources
Novel Evasion Mechanisms of the Classical Complement Pathway. [PDF]
J Immunol, 2016 Abstract Complement is a network of soluble and cell surface-associated proteins that gives rise to a self-amplifying, yet tightly regulated system with fundamental roles in immune surveillance and clearance. Complement becomes activated on the surface of nonself cells by one of three initiating mechanisms known as the classical, lectin,
Garcia BL +3 more
europepmc +5 more sources
Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein [PDF]
Frontiers in Immunology, 2021 The impairment of the alternative complement pathway contributes to rare kidney diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Aleksandra Urban +15 more
doaj +4 more sources
Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity [PDF]
Journal of Neuroinflammation, 2021 Background Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions.
Emil Gregersen +7 more
doaj +2 more sources
The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. [PDF]
PLoS Pathogens, 2012 The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali +15 more
doaj +6 more sources
The classical pathway triggers pathogenic complement activation in membranous nephropathy [PDF]
Nature Communications, 2023 It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN and ...
Larissa Seifert +23 more
doaj +2 more sources
A New Tool for Complement Research: In vitro Reconstituted Human Classical Complement Pathway [PDF]
Frontiers in Immunology, 2018 The complement, as part of the innate immune system, represents the first line of defense against Gram-negative bacteria invading the bloodstream. The complement system is a zymogen cascade that ultimately assemble into the so-called membrane attack ...
Michele Mutti +4 more
doaj +2 more sources
Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG [PDF]
Frontiers in Immunology, 2019 Members of the PfEMP1 protein family are expressed on the surface of P. falciparum-infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are important targets of acquired immunity.
Mads Delbo Larsen +8 more
doaj +2 more sources
Complement-Coagulation Cross-talk: Factor H-mediated regulation of the Complement Classical Pathway activation by fibrin clots [PDF]
Frontiers in ImmunologyThe classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. However,
Yu-Hoi Kang +7 more
doaj +4 more sources
Continual Low-Level Activation of the Classical Complement Pathway [PDF]
The Journal of Experimental Medicine, 2001 There is evidence that the classical complement pathway may be activated via a “C1-tickover” mechanism, analogous to the C3-tickover of the alternative pathway. We have quantitated and characterized this pathway of complement activation. Analysis of freshly collected mouse and human plasma revealed that spontaneous C3 activation rapidly occurred with ...
Anthony P. Manderson +4 more
openalex +6 more sources