Results 1 to 10 of about 277,934 (283)

Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity [PDF]

Journal of Neuroinflammation, 2021
Background Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions.
Emil Gregersen, Cristine Betzer, Woojin S. Kim, Gergo Kovacs, Lasse Reimer, Glenda M. Halliday, Steffen Thiel, Poul Henning Jensen   +7 more
doaj   +2 more sources

Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. [PDF]

PLoS Pathogens, 2016
Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
Brandon L Garcia, Hui Zhi, Beau Wager, Magnus Höök, Jon T Skare   +4 more
doaj   +3 more sources

A New Tool for Complement Research: In vitro Reconstituted Human Classical Complement Pathway [PDF]

Frontiers in Immunology, 2018
The complement, as part of the innate immune system, represents the first line of defense against Gram-negative bacteria invading the bloodstream. The complement system is a zymogen cascade that ultimately assemble into the so-called membrane attack ...
Michele Mutti, Katharina Ramoni, Gábor Nagy, Eszter Nagy, Valéria Szijártó   +4 more
doaj   +2 more sources

Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG [PDF]

Frontiers in Immunology, 2019
Members of the PfEMP1 protein family are expressed on the surface of P. falciparum-infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are important targets of acquired immunity.
Mads Delbo Larsen, Mads Delbo Larsen, Maria del Pilar Quintana, Sisse Bolm Ditlev, Rafael Bayarri-Olmos, Michael Fokuo Ofori, Lars Hviid, Lars Hviid, Peter Garred   +8 more
doaj   +2 more sources

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA [PDF]

Cell Reports, 2019
Summary: Movement is an essential behavior requiring the assembly and refinement of spinal motor circuits. However, the mechanisms responsible for circuit refinement and synapse maintenance are poorly understood.
Aleksandra Vukojicic, Nicolas Delestrée, Emily V. Fletcher, John G. Pagiazitis, Sethu Sankaranarayanan, Ted A. Yednock, Ben A. Barres, George Z. Mentis   +7 more
doaj   +2 more sources

The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection [PDF]

Frontiers in Immunology, 2018
Activation of the classical complement pathway occurs to varying degrees within strains of the Borrelia burgdorferi sensu lato complex, which contain a group of pathogenic spirochetes that cause tick-borne Lyme borreliosis, including the agent of Lyme ...
Hui Zhi, Jialei Xie, Jon T. Skare
doaj   +2 more sources

First-in-human study with SAR445088: A novel selective classical complement pathway inhibitor. [PDF]

Clin Transl Sci, 2023
Chow T, Shamszad P, Vinnard C, Yoon E, Belinski J, Karpenko I, Perrin L, Auwarter K, Storek M, Surks H, Wong N, Cohen YZ.   +11 more
europepmc   +3 more sources

Classical Complement Pathway Inhibition in a "Human-On-A-Chip" Model of Autoimmune Demyelinating Neuropathies. [PDF]

Adv Ther (Weinh), 2022
Rumsey JW, Lorance C, Jackson M, Sasserath T, McAleer CW, Long CJ, Goswami A, Russo MA, Raja SM, Gable KL, Emmett D, Hobson-Webb LD, Chopra M, Howard JF, Guptill JT, Storek MJ, Alonso-Alonso M, Atassi N, Panicker S, Parry G, Hammond T, Hickman JJ.   +21 more
europepmc   +3 more sources

A distinct variant of the SzM protein of Streptococcus equi subsp. zooepidemicus recruits C1q independent of IgG binding and inhibits activation of the classical complement pathway. [PDF]

Virulence, 2023
Bergmann R, Schroedl W, Müller U, Baums CG.   +3 more
europepmc   +3 more sources

Therapeutic Hypothermia Inhibits the Classical Complement Pathway in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy. [PDF]

Front Neurosci, 2021
Shah TA, Pallera HK, Kaszowski CL, Bass WT, Lattanzio FA.   +4 more
europepmc   +3 more sources