Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity [PDF]
Journal of Neuroinflammation, 2021 Background Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions.
Emil Gregersen +7 more
doaj +7 more sources
Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG [PDF]
Frontiers in Immunology, 2019 Members of the PfEMP1 protein family are expressed on the surface of P. falciparum-infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are important targets of acquired immunity.
Mads Delbo Larsen +8 more
doaj +3 more sources
Novel Evasion Mechanisms of the Classical Complement Pathway. [PDF]
J Immunol, 2016 Abstract Complement is a network of soluble and cell surface-associated proteins that gives rise to a self-amplifying, yet tightly regulated system with fundamental roles in immune surveillance and clearance. Complement becomes activated on the surface of nonself cells by one of three initiating mechanisms known as the classical, lectin,
Garcia BL +3 more
europepmc +5 more sources
The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA [PDF]
Cell Reports, 2019 Summary: Movement is an essential behavior requiring the assembly and refinement of spinal motor circuits. However, the mechanisms responsible for circuit refinement and synapse maintenance are poorly understood.
Aleksandra Vukojicic +7 more
doaj +3 more sources
The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection [PDF]
Frontiers in Immunology, 2018 Activation of the classical complement pathway occurs to varying degrees within strains of the Borrelia burgdorferi sensu lato complex, which contain a group of pathogenic spirochetes that cause tick-borne Lyme borreliosis, including the agent of Lyme ...
Hui Zhi, Jialei Xie, Jon T. Skare
doaj +3 more sources
A New Tool for Complement Research: In vitro Reconstituted Human Classical Complement Pathway [PDF]
Frontiers in Immunology, 2018 The complement, as part of the innate immune system, represents the first line of defense against Gram-negative bacteria invading the bloodstream. The complement system is a zymogen cascade that ultimately assemble into the so-called membrane attack ...
Michele Mutti +4 more
doaj +5 more sources
First-in-human study with SAR445088: A novel selective classical complement pathway inhibitor. [PDF]
Clin Transl Sci, 2023 SAR445088 is an anti‐C1s humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system and has the potential to provide clinical benefit in the treatment of complement‐mediated diseases.
Chow T +11 more
europepmc +2 more sources
Safety and efficacy of classical complement pathway inhibition with sutimlimab in chronic immune thrombocytopenia. [PDF]
Blood Adv, 2023 Key Points • Classical complement pathway activation contributes to the pathophysiology and clinical heterogeneity of immune thrombocytopenia (ITP).• Sutimlimab rapidly and durably increased platelet count in patients with chronic ITP by selectively ...
Broome CM +8 more
europepmc +2 more sources
Classical Complement Pathway Inhibition in a "Human-On-A-Chip" Model of Autoimmune Demyelinating Neuropathies. [PDF]
Adv Ther (Weinh), 2022 Chronic autoimmune demyelinating neuropathies are a group of rare neuromuscular disorders with complex, poorly characterized etiology. Here the authors describe a phenotypic, human‐on‐a‐chip (HoaC) electrical conduction model of two rare autoimmune ...
Rumsey JW +21 more
europepmc +2 more sources
Inflammasome-Dependent Peroxiredoxin 2 Secretion Induces the Classical Complement Pathway Activation. [PDF]
Immune Netw, 2021 Peroxiredoxins (Prxs) are ubiquitously expressed peroxidases that reduce hydrogen peroxide or alkyl peroxide production in cells. Prxs are released from cells in response to various stress conditions, and they function as damage-associated molecular ...
Park CH, Lee HS, Kwak MS, Shin JS.
europepmc +2 more sources