Results 111 to 120 of about 248,487 (359)

Legionella pneumophila lipopolysaccharide activates the classical complement pathway [PDF]

Infection and Immunity, 1992
Legionella pneumophila is a gram-negative bacterium capable of entering and growing in alveolar macrophages and monocytes. Complement and complement receptors are important in the uptake of L. pneumophila by human mononuclear phagocytes. The surface molecules of L. pneumophila that activate the complement system are unknown.
Duane R. Schultz, C S Mintz, Warren D. Johnson, P I Arnold   +3 more
openaire   +3 more sources

The role of complement in Streptococcus pneumoniae-associated haemolytic uraemic syndrome [PDF]

, 2013
Background. Atypical forms of haemolytic uraemic syndrome (aHUS) include HUS caused by defects in the regulation of alternative complement pathway and HUS linked to neuraminidase- producing pathogens, such as Streptococcus pneumoniae. Increasing data
Szilágyi, Ágnes
core  

A Computational and Experimental Study of the Regulatory Mechanisms of the Complement System [PDF]

, 2010
The complement system is key to innate immunity and its activation is necessary for the clearance of bacteria and apoptotic cells. However, insufficient or excessive complement activation will lead to immune-related diseases. It is so far unknown how the
A Krarup, A Thern, AA Korotaevskiy, AF Zadura, AM Blom, AM Blom, AM Blom, Anna M. Blom, AP Sjoberg, AP Sjoberg, B Dahlback, B Liu, B Selander, Benjamin Leong, Bing Liu, Bow Ho, C Mold, CJ Langmead, D Ricklin, D Sheskin, David Hsu, DH Anderson, DT Fearon, DT Fearon, G Koh, H Hirayama, I Gigli, I Gigli, J Gunawardena, J Scharfstein, J Zhang, Jeak Ling Ding, JH Griffin, Jing Zhang, K Berggard, KP Murphy, KP Murphy, L Marnell, L Truedsson, LM Boerger, M Bozga, M Jaeger, M Matsushita, M Okroj, MH Kaplan, MJ Walport, MJ Walport, MV Suresh, N Rawal, NA van Riel, NV Prasadarao, P. S. Thiagarajan, Pei Yi Tan, PM Ng, R Veerhuis, Rustom Antia, S Hoops, S Jha, S Ram, SR Barnum, Sunil Sethi, T Fujita, T Meri, T Nordstrom, V Kirjavainen, X Ji, Z Fishelson, Z Zi   +67 more
core   +4 more sources

Molecular Screening of SCN1A‐Related Seizures in Children With Febrile Seizures: Diagnostic Yield and Variant Distribution

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SCN1A‐related seizures first present as febrile seizures (FS). Definitive features emerge later, making early diagnosis challenging. We evaluated the diagnostic yield and clinical characteristics of pathogenic SCN1A variants in FS, and analyzed the effect of variant characteristics on clinical phenotypes required for early ...
Jia Wang, Yang‐Yang Wang, Lin‐Yan Hu, Xiu‐Yu Shi, Wen He, Dan Sun, Baoguang Li, Xiaoming Liu, Sanqing Xu, Lijun Du, Chunhui Tang, Li‐Ping Zou   +11 more
wiley   +1 more source

Preanalytical classical and alternative complement pathway activity loss

Biochemia medica, 2019
Introduction: Complement functional analyses provide insight into the integrity of the entire complement reaction cascade. These tests are suitable for investigating suspected complement deficiencies. Falsely reduced test outcomes may result from preanalytical instabilities of individual complement components.
Stijn Lambrecht, Koen Vercauteren, Joris R. Delanghe   +2 more
openaire   +3 more sources

Stability of C3 Convertase in the Rat Classical Complement Pathway [PDF]

Microbiology and Immunology, 1997
AbstractIt has been reported that rat serum complement causes efficient hemolysis of antibody‐sensitized sheep erythrocytes (EA) at 20 C but not at 37 C. In connection with this, we demonstrated that C3 convertase of rat complement was significantly unstable at 37 C using purified components of rat complement.
Hidechika Okada, Akihiro Naito
openaire   +3 more sources

Efgartigimod Combined With Steroid Treatment for HAM/TSP: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurological disorder with limited treatment options. We report a 54‐year‐old female with decade‐long, progressive HAM/TSP, previously refractory to rituximab, who experienced worsening spastic paraparesis and neurogenic bladder dysfunction.
Jiahui Zeng, Wotu Tian, Jingran Yang, Yanping Yang, Li Cao, Xinghua Luan   +5 more
wiley   +1 more source

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Anthony H. Keeble, Brodsky-Doyle, Chen, Chen, Christopher Furze, Daniel A. Mitchell, Doliana, Emsley, Fan, Feinberg, Girija, Haurum, Heise, Hohenester, Hoppe, Jensenius, Julia Toth, Kaufman, Kurata, Phillips, Porter, Reid, Reid, Reid, Russell Wallis, Scherer, Shoulders, Sim, Strang, Teillet, Uemura, Umakhanth Venkatraman Girija, Wallis, Wallis, Wallis, Wallis, Wallis, Wallis, Wilhelm J. Schwaeble   +38 more
core   +2 more sources

Association of Elevated Serum S100A8/A9 Levels and Cognitive Impairment in Systemic Lupus Erythematosus Patients

Arthritis Care &Research, Accepted Article.
Objectives Cognitive impairment (CI) is common in patients with Systemic Lupus Erythematosus (SLE). Despite its prevalence, the immune mechanisms are not well understood. We previously reported elevated serum levels of S100A8/A9 and MMP‐9 in SLE patients with CI.
Carolina Muñoz‐Grajales, Michelle L Barraclough, Juan P Diaz‐Martinez, Jiandong Su, Kathleen Bingham, Mahta Kakvan, Roberta Pozzi Kretzmann, Maria Carmela Tartaglia, Lesley Ruttan, May Y Choi, Simone Appenzeller, Sherief Marzouk, Dennisse Bonilla, Patricia Katz, Dorcas Beaton, Robin Green, Dafna D. Gladman, Joan Wither, Zahi Touma   +18 more
wiley   +1 more source

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source