Results 171 to 180 of about 277,934 (283)

Mesangial C1q Deposition in IgA Nephropathy: Does the Classical Complement Pathway Play an Independent Role? [PDF]

Indian J Nephrol
Gaggero G, Mazzocco K, Cafferata B, Angeletti A.   +3 more
europepmc   +1 more source

Serum Amyloid P Component Bound to Gram-Negative Bacteria Prevents Lipopolysaccharide-Mediated Classical Pathway Complement Activation

, 2000
Carla J. C. de Haas, Ester M. M. van Leeuwen, Toon van Bommel, J. Verhoef, Kok P. M. van Kessel, Jos A. G. van Strijp   +5 more
openalex   +1 more source

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

Advanced Science, EarlyView.
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty   +20 more
wiley   +1 more source

Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs. [PDF]

J Immunol
Xu X, Herdendorf TJ, Duan H, Rohlik DL, Roy S, Zhou H, Alkhateeb H, Khandelwal S, Zhou Q, Li P, Arepally GM, Walker JK, Garcia BL, Geisbrecht BV.   +13 more
europepmc   +1 more source

9. Adenovirus Vector Induced Immune Responses Are Dependent upon Multi-Faceted Interactions with Proteins of Both the Alternative and Classical Complement Pathways In Vivo [PDF]

, 2007

openalex   +1 more source

Tumor Microenvironment On‐A‐Chip and Single‐Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression

Advanced Science, EarlyView.
Using a 3D tumor microenvironment (TME)‐on‐a‐chip model, tumor–stromal–immune crosstalk in triple‐negative breast cancer is studied, revealing the TME's combinatorial effect on cancer progression. Integrating single‐cell transcriptomic analysis demonstrates metabolic reprogramming via the kynurenine pathway, highlighting the complex TME cellular ...
Kalpana Ravi, Yining Zhang, Lydia Sakala, Twinkle Jina Minette Manoharan, Barbara Pockaj, Joshua LaBaer, Jin G. Park, Mehdi Nikkhah   +7 more
wiley   +1 more source

Continual Low-Level Activation of the Classical Complement Pathway

, 2001
Anthony P. Manderson, Matthew C. Pickering, Marina Botto, Mark Walport, Christopher R. Parish   +4 more
openalex   +1 more source

Highly specific inhibition of C1q globular-head binding to human IgG: A novel approach to control and regulate the classical complement pathway using an engineered single chain antibody variable fragment [PDF]

, 2008
Hee Hwang, Marcus R. Duvall, Stephen Tomlinson, Robert J. Boackle   +3 more
openalex   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source

Copy number variants suggest different molecular pathways for the pathogenesis of bladder exstrophy

American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 378-390, February 2023., 2023
Abstract Bladder exstrophy is a rare congenital malformation leaving the urinary bladder open in the midline of the abdomen at birth. There is a clear genetic background with chromosome aberrations, but so far, no consistent findings apart from 22q11‐duplications detected in about 2%–3% of all patients.
Agneta Nordenskjöld, Samara Arkani, Maria Pettersson, Johanna Winberg, Jia Cao, Magdalena Fossum, Magnus Anderberg, Gillian Barker, Gundela Holmdahl, Johanna Lundin   +9 more
wiley   +1 more source