Results 171 to 180 of about 265,122 (221)

Targeting Classical Complement Pathway to Treat Complement Mediated Autoimmune Diseases

2008
Mice deficient for classical complement pathway (CCP) factor C4 are resistant to antibody and complement mediated experimental autoimmune myasthenia gravis (EAMG). Anti-C1q antibody administration before or following acetylcholine receptor immunization suppresses EAMG development by reducing lymph node cell IL-6 production and neuromuscular junction ...
Erdem, Tüzün, Jing, Li, Shamsher S, Saini, Huan, Yang, Premkumar, Christadoss   +4 more
openaire   +2 more sources

Activation of the classical complement pathway by BioRex-70

Immunology Letters, 1987
The cation exchange resin BioRex-70 was able to activate the classical complement pathway in human serum at 37 degrees C over the resin concentration range 0-5% (v/v). Using zymosan-treated human serum, it was found that the activation proceeded as far as complement protein C3.
R J, Vandenberg, S B, Easterbrook-Smith
openaire   +2 more sources

Effect of Concanavalin A on the Classical Complement Pathway

The Journal of Immunology, 1977
Abstract Lysis of sheep erythrocytes (E) sensitized with anti-Forssman antiserum (EA) is inhibited by the action of concanavalin A (Con A) on whole guinea pig complement (GPC). The degree of inhibition observed for a given quantity of GPC was dependent on the Con A concentration.
J J, Langone, M D, Boyle, T, Borsos
openaire   +2 more sources

The non-classical functions of the classical complement pathway recognition subcomponent C1q

Immunology Letters, 2010
C1q, the ligand recognition subcomponent of the classical complement pathway has steadily been gaining recognition as a bridge between innate and adaptive immunity. C1q has been shown to be involved in the modulation of various immune cells (such as dendritic cells, platelets, microglia cells and lymphocytes), clearance of apoptotic cells, a range of ...
Annapurna, Nayak, Janez, Ferluga, Anthony G, Tsolaki, Uday, Kishore   +3 more
openaire   +2 more sources

The Classical Pathway of Complement

2016
Complement evolved in parallel with coagulation as part of the primordial explosion of life in the Cambrian era. Remnants of this connection still exist in vertebrate animals as well as invertebrates. A classic example is the horseshoe crab, Limulus polyphemus, still sought after by scientists today to test substances for traces of bacterial ...
openaire   +1 more source

Synthesis of classical pathway complement components by chondrocytes.

Immunology, 1996
Using immunohistochemical studies, C1q, C1s, C4 and C2 were detected in chondrocytes in normal human articular cartilage and macroscopically normal articular cartilage from the inferior surfaces of hip joints of patients with osteoarthritis. Using reverse-transcribed polymerase chain reaction (RT-PCR), mRNA for C1q, C1s, C4 and C2 was also detected in ...
Bradley, K., North, J., Saunders, D., Schwaeble, W., Jeziorska, M., Woolley, D. E., Whaley, K.   +6 more
openaire   +2 more sources

Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy

Blood
Abstract Complement-mediated thrombotic microangiopathy (CM-TMA) or hemolytic uremic syndrome, previously identified as atypical hemolytic uremic syndrome, is a TMA characterized by germ line variants or acquired antibodies to complement proteins and regulators.
Michael A. Cole, Nikhil Ranjan, Gloria F. Gerber, Xiang-Zuo Pan, Daniel Flores-Guerrero, George McNamara, Shruti Chaturvedi, C. John Sperati, Keith R. McCrae, Robert A. Brodsky   +9 more
openaire   +2 more sources

Classical pathway of complement activation in mammalian kidneys.

Immunology, 1994
Two monoclonal antibodies (mAb M4d2 and M4d3) specific for the alpha 2-fragment (C4d), and one antibody (mAb M4c3) specific for the gamma-chain of human complement protein C4, have been tested for cross-reactivity against mammalian complement. These mAb have also been found to react with C4 from guinea-pig (mAb M4d2 and M4c3) as well as from cattle ...
J, Zwirner, E, Felber, R, Burger, D, Bitter-Suermann, G, Riethmüller, H E, Feucht   +5 more
openaire   +2 more sources

Classical Complement Pathway in Experimental Autoimmune Myasthenia Gravis Pathogenesis

Annals of the New York Academy of Sciences, 2008
Mice deficient for complement factors C3, C4, or C5 are resistant to experimental autoimmune myasthenia gravis (EAMG). Acetylcholine receptor (AChR) immune lymph node cells (LNC) of C3 deficient mice produce less interleukin 6 (IL‐6), and EAMG‐resistant IL‐6 deficient mice have less serum C3.
Premkumar, Christadoss, Erdem, Tüzün, Jing, Li, Shamsher S, Saini, Huan, Yang   +4 more
openaire   +2 more sources

CLASSICAL COMPLEMENT PATHWAY IN HIV INFECTION

The Lancet, 1989
G, Senaldi, M, Peakman, T, McManus, E T, Davies, D E, Tee, D, Vergani   +5 more
openaire   +2 more sources