Results 181 to 190 of about 265,122 (221)

Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy

Experimental Neurology, 2017
Season K Wyatt, T. Witt, N. Barbaro, A. Cohen-Gadol, A. Brewster   +4 more
semanticscholar   +1 more source

Complement Biosensors Identify a Classical Pathway Stimulus in Complement-Mediated Hemolytic Uremic Syndrome

AbstractComplement-mediated hemolytic uremic syndrome (CM-HUS) is a thrombotic microangiopathy characterized by germline variants or acquired antibodies to complement proteins and regulators. Building upon our prior experience with the modified Ham (mHam) assay for ex vivo diagnosis of complementopathies, we have developed an array of cell-based ...
Michael A. Cole, Nikhil Ranjan, Gloria F. Gerber, Xiang-Zuo Pan, Daniel Flores-Guerrero, Shruti Chaturvedi, C. John Sperati, Keith R. McCrae, Robert A. Brodsky   +8 more
openaire   +2 more sources

Classical pathway complement activation in association with paraproteinaemia.

Immunology, 1978
Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four.
P F, Naish, C, Collins, J, Barratt
openaire   +1 more source

Classical complement pathway components C1r and C1s: purification from human serum and in recombinant form and functional characterization.

Methods in molecular biology, 2014
V. Rossi, I. Bally, M. Lacroix, G. Arlaud, N. Thielens   +4 more
semanticscholar   +1 more source

The adenosine pathway in immuno-oncology

Nature Reviews Clinical Oncology, 2020
Bertrand Allard, Laurence Buisseret, John Stagg   +2 more
exaly  

The cGAS–STING pathway as a therapeutic target in inflammatory diseases

Nature Reviews Immunology, 2021
Alexiane Decout, Andrea Ablasser
exaly  

Lineage plasticity in cancer: a shared pathway of therapeutic resistance

Nature Reviews Clinical Oncology, 2020
Helena A Yu, Dana Pe'er, Charles L Sawyers   +2 more
exaly  

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy

Chemical Reviews, 2022
Kyle M Garland, Taylor L Sheehy, John T Wilson   +2 more
exaly  

The classical pathway of complement

The Biomedical & Life Sciences Collection, 2017
openaire   +1 more source

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

Ca-A Cancer Journal for Clinicians, 2011
Timothy A Yap, Johann Sebastian de Bono
exaly