Carbamylation of immunoglobulin abrogates activation of the classical complement pathway. [PDF]
Eur J Immunol, 2014 Post‐translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory conditions through myeloperoxidase‐dependent cyanate (CNO−) formation.
Koro C +12 more
europepmc +10 more sources
Classical pathway complement activation in Kawasaki syndrome
Journal of Allergy and Clinical Immunology, 1994 In this study the complement breakdown products C3d, C4d, Bb and membrane attack complex were measured in plasma of patients with Kawasaki syndrome. The results suggested strong activation of the classical activation pathway. However, there was no significant decrease in hemolytic titer or in the concentrations of the intact proteins C3, C4, and B. The
Takao Kohsaka +3 more
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Classical Complement Pathway Activation in the Kidneys of Women With Preeclampsia. [PDF]
Hypertension, 2015 A growing body of evidence suggests that complement dysregulation plays a role in the pathogenesis of preeclampsia. The kidney is one of the major organs affected in preeclampsia. Because the kidney is highly susceptible to complement activation, we hypothesized that preeclampsia is associated with renal complement activation. We performed a nationwide
Penning M +10 more
europepmc +7 more sources
C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]
Nature Communications, 2016 C1q is known to initiate the activation of the complement classical pathway. Here, the authors show the C1q is expressed in the tumour microenvironment and can promote cancer cell migration and adhesion in a complement activation-independent manner.
Roberta Bulla +9 more
doaj +3 more sources
Alterations in the complement cascade in post-traumatic stress disorder [PDF]
Allergy, Asthma & Clinical Immunology, 2010 Background In the present study we assessed the functional state of the major mediator of the immune response, the complement system, in post-traumatic stress disorder (PTSD).
Hovhannisyan Lilit P +3 more
doaj +5 more sources
Preanalytical classical and alternative complement pathway activity loss [PDF]
Biochemia medica, 2019 Introduction: Complement functional analyses provide insight into the integrity of the entire complement reaction cascade. These tests are suitable for investigating suspected complement deficiencies. Falsely reduced test outcomes may result from preanalytical instabilities of individual complement components.
Stijn Lambrecht +2 more
openaire +5 more sources
The phylogeny of the complement system and the origins of the classical pathway
Immunobiology, 2007 The origins of the complement system have now been traced to near to the beginnings of multi-cellular animal life. Most of the evidence points to the earliest activation mechanism having been more similar to the lectin pathway than to the alternative pathway.
Alister W. Dodds, Misao Matsushita
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Editorial: State-of-the-Art Research on C1q and the Classical Complement Pathway. [PDF]
Front Immunol, 2016 International ...
Kishore U, Thielens NM, Gaboriaud C.
europepmc +6 more sources
The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA [PDF]
Cell Reports, 2019 Summary: Movement is an essential behavior requiring the assembly and refinement of spinal motor circuits. However, the mechanisms responsible for circuit refinement and synapse maintenance are poorly understood.
Aleksandra Vukojicic +7 more
doaj +2 more sources
The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection [PDF]
Frontiers in Immunology, 2018 Activation of the classical complement pathway occurs to varying degrees within strains of the Borrelia burgdorferi sensu lato complex, which contain a group of pathogenic spirochetes that cause tick-borne Lyme borreliosis, including the agent of Lyme ...
Hui Zhi, Jialei Xie, Jon T. Skare
doaj +2 more sources