C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]
Acta Neuropathol Commun, 2016 Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A. +8 more
core +4 more sources
First‐in‐human study with SAR445088: A novel selective classical complement pathway inhibitor [PDF]
Clin Transl Sci, 2023 SAR445088 is an anti‐C1s humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system and has the potential to provide clinical benefit in the treatment of complement‐mediated diseases.
Timothy Y. Chow +11 more
europepmc +3 more sources
Classical Complement Pathway Inhibition in a “Human‐On‐A‐Chip” Model of Autoimmune Demyelinating Neuropathies [PDF]
Adv Ther (Weinh), 2022 Chronic autoimmune demyelinating neuropathies are a group of rare neuromuscular disorders with complex, poorly characterized etiology. Here the authors describe a phenotypic, human‐on‐a‐chip (HoaC) electrical conduction model of two rare autoimmune ...
John W. Rumsey +21 more
europepmc +3 more sources
Safety and efficacy of classical complement pathway inhibition with sutimlimab in chronic immune thrombocytopenia. [PDF]
Blood Adv, 2023 Key Points • Classical complement pathway activation contributes to the pathophysiology and clinical heterogeneity of immune thrombocytopenia (ITP).• Sutimlimab rapidly and durably increased platelet count in patients with chronic ITP by selectively ...
Broome CM +8 more
europepmc +2 more sources
Inflammasome-Dependent Peroxiredoxin 2 Secretion Induces the Classical Complement Pathway Activation. [PDF]
Immune Netw, 2021 Peroxiredoxins (Prxs) are ubiquitously expressed peroxidases that reduce hydrogen peroxide or alkyl peroxide production in cells. Prxs are released from cells in response to various stress conditions, and they function as damage-associated molecular ...
Park CH, Lee HS, Kwak MS, Shin JS.
europepmc +2 more sources
Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity. [PDF]
J Neuroinflammation, 2021 Background Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions.
Gregersen E +7 more
europepmc +2 more sources
Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG. [PDF]
Front Immunol, 2018 Members of the PfEMP1 protein family are expressed on the surface of P. falciparum-infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are important targets of acquired immunity.
Larsen MD +6 more
europepmc +2 more sources
Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway. [PDF]
Diabetes, 2018 Diabetic retinopathy (DR) is a microvascular complication of diabetes and is the leading cause of vision loss in working-age adults. Recent studies have implicated the complement system as a player in the development of vascular damage and progression of
Huang C +5 more
europepmc +2 more sources
The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection. [PDF]
Front Immunol, 2018 Activation of the classical complement pathway occurs to varying degrees within strains of the Borrelia burgdorferi sensu lato complex, which contain a group of pathogenic spirochetes that cause tick-borne Lyme borreliosis, including the agent of Lyme ...
Zhi H, Xie J, Skare JT.
europepmc +2 more sources
A Randomized, First-in-Human, Healthy Volunteer Trial of sutimlimab, a Humanized Antibody for the Specific Inhibition of the Classical Complement Pathway. [PDF]
Clin Pharmacol Ther, 2018 Aberrant activation of the classical complement pathway is the common underlying pathophysiology of orphan diseases such as bullous pemphigoid, antibody‐mediated rejection of organ transplants, cold agglutinin disease, and warm autoimmune hemolytic ...
Bartko J +10 more
europepmc +2 more sources