Editorial: State-of-the-Art Research on C1q and the Classical Complement Pathway. [PDF]
Front Immunol, 2016 Complement protein C1q is a fascinating innate immune molecule. C1q is the first subcomponent of the classical complement pathway. Its primary three-chain structure (A, B, and C chains), which is composed of a triple-helical collagen-like region and a C ...
Kishore U, Thielens NM, Gaboriaud C.
europepmc +14 more sources
Delayed Hemolytic Transfusion Reaction in a Patient With Sickle Cell Disease and the Role of the Classical Complement Pathway: A Case Report. [PDF]
J Hematol, 2021 A 14-year-old female patient with sickle cell disease developed a severe delayed hemolytic transfusion reaction (DHTR) leading to multiple transfusions and intensive care management.
Hair PS +7 more
europepmc +2 more sources
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. [PDF]
PLoS Pathogens, 2016 Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
Brandon L Garcia +4 more
doaj +11 more sources
Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway. [PDF]
Diabetes, 2018 Diabetic retinopathy (DR) is a microvascular complication of diabetes and is the leading cause of vision loss in working-age adults. Recent studies have implicated the complement system as a player in the development of vascular damage and progression of
Huang C +5 more
europepmc +2 more sources
A Randomized, First-in-Human, Healthy Volunteer Trial of sutimlimab, a Humanized Antibody for the Specific Inhibition of the Classical Complement Pathway. [PDF]
Clin Pharmacol Ther, 2018 Aberrant activation of the classical complement pathway is the common underlying pathophysiology of orphan diseases such as bullous pemphigoid, antibody‐mediated rejection of organ transplants, cold agglutinin disease, and warm autoimmune hemolytic ...
Bartko J +10 more
europepmc +2 more sources
The classical pathway triggers pathogenic complement activation in membranous nephropathy
Nature Communications, 2023 It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN and ...
Larissa Seifert +23 more
doaj +2 more sources
The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. [PDF]
PLoS Pathogens, 2012 The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali +15 more
doaj +6 more sources
Frontiers in Immunology, 2020 The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies.
Nick S. Laursen +7 more
doaj +2 more sources
C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]
Acta Neuropathologica Communications, 2016 Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
R. McGonigal +8 more
semanticscholar +4 more sources
Deficient Classical Complement Pathway Activity in Newborn Sera [PDF]
Pediatric Research, 1983 Summary: The bactericidal activity of 20 maternal-neonatal paired sera was assessed employing a clinical type la, group B streptococcal isolate, strain 515, known to be opsonized by the classical complement pathway in a non-antibody dependent fashion.
M S, Edwards +4 more
openaire +3 more sources