Results 251 to 260 of about 387,249 (358)

Molluskan Hemocyanins Activate the Classical Pathway of the Human Complement System through Natural Antibodies [PDF]

, 2017
Javier Pizarro-Bäuerle, Ismael Maldonado, Eduardo Sosoniuk-Roche, Gerardo Vallejos, Mercedes López, Flavio Salazar‐Onfray, Lorena Aguilar-Guzmán, Carolina Valck, Arturo Ferreira, Marı́a Inés Becker   +9 more
openalex   +1 more source

Soft Bioelectronic Interfaces for Continuous Peripheral Neural Signal Recording and Robust Cross‐Subject Decoding

Advanced Science, EarlyView.
A soft poly (3,4‐ethylenedioxythiophene):poly (styrenesulfonate)‐based electrode enables continuous, high‐quality recording of peripheral nerve activity. A neural network model integrating handcrafted and convolutional neural network‐based features decodes whisker movements with strong generalization, offering insights into peripheral nerve function ...
Liangpeng Chen, Yang Liu, Yewei Huang, Ziyang Li, Chao Zhang, Jun Tang, Xueyuan Ling, Bowen Cao, Baowang Li, Yuan Zhang, Wenjianlong Zhou, Qin Xu, Shunchang Ma, Xiudong Guan, Dan Xiao, Jingyao Geng, Yutong Zhao, Guolin Li, Yi‐xuan Wang, Wang Jia, Yuanwen Jiang, Milin Zhang, Deling Li   +22 more
wiley   +1 more source

Classical complement pathway activation in the nasal tissue of patients with chronic rhinosinusitis. [PDF]

J Allergy Clin Immunol, 2017
Van Roey GA, Vanison CC, Wu J, Huang JH, Suh LA, Carter RG, Norton JE, Shintani-Smith S, Conley DB, Welch KC, Peters AT, Grammer LC, Harris KE, Hulse KE, Kato A, Stevens WW, Kern RC, Schleimer RP, Tan BK.   +18 more
europepmc   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Editorial: The Role of Complement in Health and Disease

Frontiers in Immunology, 2019
Maciej Cedzyński, Nicole M. Thielens, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Thomas Vorup-Jensen, Thomas Vorup-Jensen   +6 more
doaj   +1 more source

Killing of dsrA Mutants of Haemophilus ducreyi by Normal Human Serum Occurs via the Classical Complement Pathway and Is Initiated by Immunoglobulin M Binding

, 2005
M. Abdullah, I. Nepluev, G. Afonina, S. Ram, P. Rice, W. Cade, C. Elkins   +6 more
openalex   +2 more sources

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei   +11 more
wiley   +1 more source

Anti-C1s humanized monoclonal antibody SAR445088: A classical pathway complement inhibitor specific for the active form of C1s

, 2023
Ken T. Simmons, Joanne Chan, Sami Hussain, Eileen L. Rose, Kate Markham, Tony Byun, Sandip Panicker, Graham C. Parry, Michael Storek   +8 more
openalex   +1 more source

Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity

Advanced Science, EarlyView.
Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi, Claudia Corbo, Julia Enterria‐Rosales, John Otto Martinez, Silvia Minardi, Laura Pandolfi, Xing Wang, Ennio Tasciotti, Kavindra V. Singh, Cesar A. Arias, Bruna Corradetti   +10 more
wiley   +1 more source

Classical complement pathway activation in immune thrombocytopenia purpura: inhibition by a novel C1s inhibitor. [PDF]

Br J Haematol, 2016
Peerschke EI, Panicker S, Bussel J.
europepmc   +1 more source