Results 251 to 260 of about 277,934 (283)

Pharmacokinetic analysis on compatibility of Atractylodes macrocephala and Paeoniae radix herb pair ameliorates functional constipation model rats using microdialysis with ultra‐performance liquid chromatography

Animal Models and Experimental Medicine, EarlyView.
The active ingredient of the drug determines the effect of the drug, and the compatibility affects the content of the active ingredient of the drug, which in turn affects the exertion of the efficacy. This study partly clarifies the rationality and compatibility of AM‐PR in the treatment of FC.
Xiaoting Wang, Xiaojun Li, Rui Zhang, Yin Hong, Jiaqi Guan   +4 more
wiley   +1 more source

Corrigendum: Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs. [PDF]

Front Immunol
Hurler L, Toonen EJM, Kajdácsi E, van Bree B, Brandwijk RJMGE, de Bruin W, Lyons PA, Bergamaschi L, Cambridge Institute of Therapeutic Immunology Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Sinkovits G, Cervenak L, Würzner R, Prohászka Z.   +12 more
europepmc   +1 more source

Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways

Animal Models and Experimental Medicine, EarlyView.
The flowchart of this research. Abstract Background Dry eye disease (DED) predominantly results from elevated tear film osmolarity, which can not only cause ocular inconvenience but may lead to visual impairments, severely compromising patient well‐being and exerting substantial economic burdens as well.
Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie   +9 more
wiley   +1 more source

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics

Annals of Neurology, EarlyView.
Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa, Ai Nagano, Simon Hametner, Owain Howell, David Owen, Artemis Papadaki, Prashant Srivastava, Simona Bonavita, Roberta Magliozzi, Richard Reynolds, Mie Rizig, Richard Nicholas   +11 more
wiley   +1 more source

Correlation between serum complement component 4 levels and tubular atrophy in patients with lupus nephritis. [PDF]

Ren Fail
Chang Z, Hu H, Cheng Y, Xu R, Wan Q.
europepmc   +1 more source

AI in Neurology: Everything, Everywhere, All at Once Part 3: Surveillance, Synthesis, Simulation, and Systems

Annals of Neurology, EarlyView.
This final part 3 review builds on the practical applications discussed in part 2 and explores how artificial intelligence (AI) is transforming data management, neurological education, and neurological care across large healthcare networks and datasets. The review also highlights AI's role in real‐world and synthetic data, digital twins, and innovative
Matthew Rizzo
wiley   +1 more source

Candidiasis: Insights into Virulence Factors, Complement Evasion and Antifungal Drug Resistance. [PDF]

Microorganisms
Gaffar NR, Valand N, Venkatraman Girija U.   +2 more
europepmc   +1 more source

Results From a Phase 1 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ANX005, a C1q Inhibitor, in Patients With Guillain-Barré Syndrome. [PDF]

J Peripher Nerv Syst
Mohammad QD, Islam Z, Papri N, Hayat S, Jahan I, Azad KAK, Artis DR, Hoehn B, Humphriss E, Lin P, Yednock T, Kroon HA.   +11 more
europepmc   +1 more source

Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study. [PDF]

Sci Rep
Pinzon-Hoyos N, Li Y, McGee M, Poolos NP, Marchi N, Brewster AL.   +5 more
europepmc   +1 more source

Two New Kindreds with Complete Factor D Deficiency. [PDF]

Eur J Immunol
Puel M, Rwayane K, Vieira Martins P, Chbihi M, Rieux-Laucat F, Rosain J, Jeziorski E, Boisson B, Casanova JL, Frémeaux-Bacchi V, El Sissy C.   +10 more
europepmc   +1 more source