Results 271 to 280 of about 61,585 (301)

Succinylated and acetylated concanavalin A activate the classical complement pathway

Biochemical and Biophysical Research Communications, 1981
Abstract Succinylated and acetylated concanavalin A, but not the native lectin, lyse sheep erythrocytes in the presence of guinea pig complement. The effect appears to be specific since succinylated wheat germ agglutinin is inactive and hemolysis is inhibited selectively by α-D-methylglucopyranoside. Hemolytic activity is enhanced by preincubation of
John J. Langone, Regina Ejzemberg
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The Classical Complement Pathway: Activation and Regulation of the First Complement Component

1985
Publisher Summary This chapter focuses on the activation and regulation of the first complement component. . The chapter outlines the history of the classical pathway of the complement system. Clq and C1 are bound and activated by immune complexes or aggregates containing IgG or IgM but not by those containing IgA, IgD, or IgE . Among IgG subclasses,
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Adiponectin binds C1q and activates the classical pathway of complement

Biochemical and Biophysical Research Communications, 2008
The adipose-specific protein adiponectin binds to a number of target molecules, including damaged endothelium and the surface of apoptotic cells. However, the significance of this binding remains unclear. This study demonstrates the binding of purified C1q to recombinant adiponectin under physiological conditions, and the dependence of this upon Ca(++)
Alexandra Walther, Philip W. Peake, John A. Charlesworth, Yvonne Shen   +3 more
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Effects of anesthesia and operation on the classical pathway of complement activation

Clinical Immunology and Immunopathology, 1982
Abstract The present study examined whether anesthesia and operation could alter serum complement function as reflected by CH 50 levels and individual component activity. Classical complement pathway function was significantly reduced, as reflected by lowered CH 50 levels, in patients undergoing anesthesia and operation.
Robert E. Lewis, Julius M. Cruse, John V. Richey   +2 more
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Synthesis of classical pathway complement components by chondrocytes.

Immunology, 1996
Using immunohistochemical studies, C1q, C1s, C4 and C2 were detected in chondrocytes in normal human articular cartilage and macroscopically normal articular cartilage from the inferior surfaces of hip joints of patients with osteoarthritis. Using reverse-transcribed polymerase chain reaction (RT-PCR), mRNA for C1q, C1s, C4 and C2 was also detected in ...
Bradley, K., North, J., Saunders, D., Schwaeble, W., Jeziorska, M., Woolley, D. E., Whaley, K.   +6 more
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[22] Molecular titration of components of the classical complement pathway

1983
Publisher Summary The complement system consists of at least 20 serum proteins that interact in a precisely defined sequence resulting in the production of biologically active by-products and, ultimately, in the destruction of, or damage to, a suitably sensitized cell. Activation of this system can be achieved by two mechanisms, namely, the classical
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CLASSICAL COMPLEMENT PATHWAY IN HIV INFECTION

The Lancet, 1989
E T Davies, Mark Peakman, T. J. Mcmanus, D.E.H. Tee, Diego Vergani, G. Senaldi   +5 more
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Classical and alternative pathway of complement in amphibia

Developmental & Comparative Immunology, 1983
B. Hofmanová, V. Dlabač, J. Šimečková, P. Šíma   +3 more
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Classical Complement Pathway

2016
Odette Middleton, Helen Wheadon, Alison M. Michie   +2 more
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The cGAS–STING pathway as a therapeutic target in inflammatory diseases

Nature Reviews Immunology, 2021
Alexiane Decout, Andrea Ablasser
exaly